Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 984 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07016815Recruiting
Remote monitoring to adjust heart failure medications
This trial tests whether checking in remotely (telemonitoring) helps doctors adjust heart failure medications more effectively. It is for people newly diagnosed with heart failure who have reduced pumping strength and signs of fluid buildup.
Hong Kong, Hong KongAges 19 years+ - NCT04848844Recruiting
Congenital heart disease transplant registry study for adults
This study collects and shares anonymous information about adults being considered for a heart transplant because of a congenital (from birth) heart problem or an inherited heart muscle condition. The goal is to better understand these patients and support research that may improve care.
HamburgAges 18 years+ - NCT07029230Recruiting
Blood test during heart surgery to predict heart failure in kids
This study looks at a substance called sST2 in the blood of children having heart surgery. The goal is to see if sST2 levels can help doctors predict heart failure after surgery.
Zurich, Canton of ZurichAges Up to 18 years - NCT07401771Recruiting
Exercise heart MRI in heart failure with preserved pumping strength
This study uses a special exercise MRI to see how the heart works during activity in people with a type of heart failure where the heart's pumping strength is normal. It also includes people with shortness of breath from other causes and healthy volunteers to compare results.
Rochester, MinnesotaAges 18–80 - NCT06166654RecruitingPhase 4
Better water pill therapy for acute heart failure
This trial tests different water pill (diuretic) strategies for people hospitalized with acute heart failure and too much fluid. It is designed for patients who may not respond well to standard water pills, to find a more effective way to relieve symptoms.
Hvidovre, Capital Region of DenmarkAges 18 years+ - NCT05609097Recruiting
Exercise program study for older adults with weaker heart pumping
This study tests a new exercise program for people over 65 with heart failure where the heart pumps less efficiently. The goal is to see if tailored exercise is safe and helpful for breathing, energy, and daily function.
Charlottesville, VirginiaAges 65 years+ - NCT05174351Recruiting
Stopping beta-blockers in heart failure with preserved pumping
This study checks whether safely stopping beta-blocker medicine is possible in some people with heart failure with preserved pumping (EF ≥50%). It may help by testing whether reducing the medication is safe and workable for certain patients.
Farmington, ConnecticutAges 50–80 - NCT02901184RecruitingPhase 3
Spironolactone start study for heart failure with preserved pumping
This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.
Alexander City, AlabamaAges 50–99 - NCT06196086Recruiting
Measuring heart stiffness in heart failure with normal pumping
This study uses a special ultrasound technique to check how stiff the heart muscle is in people with heart failure who have a normal pumping ability (HFpEF). It aims to better understand heart stiffness to help diagnose and manage this condition.
Jinan, ShandongAges 18–80 - NCT05441839Recruiting
Heart failure with preserved pumping function study in the UK
This trial studies people who have heart failure symptoms but whose heart pumping strength is largely preserved. It aims to better understand this specific type of heart failure and how best to treat or evaluate it.
AbercynonAges 18 years+ - NCT06388226Recruiting
Leg heat therapy for heart failure with preserved pumping ability
This study tests if applying heat to your legs can improve symptoms and heart function in people with a type of heart failure where the heart pumps normally but doesn't relax properly. It aims to find a simple, drug-free way to help you feel better.
Indianapolis, IndianaAges 18 years+ - NCT07595809Recruiting
Diet and exercise for heart failure with weak heart pumping
This study tests whether combining a healthy eating plan (DASH diet) with supervised exercise can help people with heart failure where the heart doesn't pump strongly enough. The goal is to see if these lifestyle changes improve heart function and symptoms.
Zabrze, Silesian VoivodeshipAges 30 years+ - NCT05525663Recruiting
Rehab for older adults after heart failure with strong pumping
This trial studies whether a physical rehabilitation program helps older adults recover and function better after a recent hospital stay for heart failure when the heart’s pumping strength is preserved. It may help you regain walking ability and daily independence after your episode.
Winston-Salem, North CarolinaAges 60 years+ - NCT07326605Enrolling by invitation
Heart MRI study for heart failure with preserved pumping function
This trial uses a special heart MRI to create pressure-volume loops in people with heart failure who have a normal pumping strength (ejection fraction of 50% or higher). It aims to better understand heart function and could help guide future treatments. You may qualify if you have heart failure symptoms and specific heart structure or function changes.
Ages 18 years+ - NCT07093528Recruiting
CS Reducer study for heart failure with preserved pumping function
This trial is testing a device called CS Reducer to see if it can help people with a certain type of heart failure (HFpEF) and a problem with small blood vessels in the heart (CMD). The device may improve blood flow and reduce symptoms.
Rochester, MinnesotaAges 18 years+ - NCT07269717RecruitingPhase 2
Testing HRS-1893 for heart failure with preserved ejection fraction
This trial tests a new drug called HRS-1893 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug can improve symptoms and quality of life.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT06685237Recruiting
Copenhagen heart failure with preserved pumping study
This study is for people in the Capital Region of Denmark who are at least 50 years old and have certain health conditions that put them at risk for a type of heart failure where the heart pumps normally but doesn't relax properly. The study aims to find and help people before heart failure develops.
HellerupAges 50–89 - NCT07650474Recruiting
Mobile app for heart failure management and quality of life
This study tests whether using a mobile phone app to monitor and manage chronic heart failure improves how you feel and function day-to-day. Researchers will check in with you regularly through your phone to track your symptoms and health.
Addis AbabaAges 18–65 - NCT04332692Recruiting
Check if a lung ultrasound helps evaluate discharge after heart failure
This study looks at whether doing lung ultrasounds can better assess people right before they leave the hospital after an acute heart failure flare. It may help doctors decide when someone is ready for discharge and tailor care to reduce risk after leaving.
Vandœuvre-lès-NancyAges 18 years+ - NCT04768322Recruiting
LVAD versus standard heart failure medicines in advanced patients
This trial compares an LVAD device (a pump placed in the chest) plus medicines versus medicines alone for people with advanced, end-stage heart failure. It aims to see which approach works better to help patients live and stay out of the hospital.
BesançonAges 18 years+ - NCT05030987Recruiting
Renal denervation for heart failure with preserved heart strength
This trial studies whether a procedure that calms overactive kidney nerves (renal denervation) can improve symptoms and heart function in people with heart failure with preserved ejection fraction. It also checks that the kidney arteries are suitable and that your blood pressure and heart pressure measurements meet the study targets.
Halle, Saxony-AnhaltAges 18–80 - NCT05479669Recruiting
Testing detailed heart scans in people with heart failure symptoms
This study looks at whether doing very detailed heart testing helps understand and guide care for people with heart failure with preserved pumping strength. You may be eligible if you’re an adult with specific symptom levels, recent heart-failure-related visits, and matching scan and blood test results.
GroningenAges 18 years+ - NCT05498584Recruiting
Testing a treatment approach for scar tissue after heart failure
This study tests an approach aimed at reducing heart scarring (fibrosis) after heart failure. It enrolls people with moderate to severe heart failure who have signs of active heart strain and can complete study tests.
Kaohsiung CityAges 20–100 - NCT05582044Recruiting
Exercise using leg suction for heart failure with preserved function
This study tests whether a specific lower-body exercise method using negative pressure (leg suction) can improve symptoms and heart-related function in people with heart failure with preserved ejection fraction (HFpEF). You may also be offered screening if you are a healthy person, to compare results.
Kelowna, British ColumbiaAges 40 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 984 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.