Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 923 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06453876RecruitingPhase 3
Comparing clot removal, low-dose clot dissolver, and heparin for high-risk lung clot
This trial compares three treatments for an intermediate-high risk pulmonary embolism: a minimally invasive clot removal procedure (embolectomy), a low-dose clot-dissolving medication, or standard blood thinning (heparin). The goal is to see which approach works best to prevent worsening while reducing bleeding risks.
CopenhagenAges 18 years+ - NCT06085664RecruitingPhase 1/Phase 2
Immunotherapy before prostate cancer surgery
This trial tests a new immunotherapy drug (REGN5678) given before surgery to men with high-risk prostate cancer that hasn't spread. The goal is to see if the drug can shrink or control the cancer before the prostate is removed.
Houston, TexasAges 18 years+ - NCT07158970Recruiting
Home ultrasound for gestational diabetes in high-risk pregnancy
This study tests whether using a small ultrasound device at home can help monitor high-risk pregnancies in people with gestational diabetes. You would perform quick scans and share them with your doctor remotely.
H̱olon, Central DistrictAges 18–51 - NCT06365619RecruitingPhase 2
Immunotherapy before surgery for recurrent melanoma
This trial tests two immunotherapy drugs, ipilimumab and nivolumab, given before surgery for people whose melanoma has come back after previous anti-PD1 treatment. The goal is to see if this combination can shrink the tumor and help prevent future recurrence.
Salt Lake City, UtahAges 18 years+ - NCT07000357RecruitingPhase 3
Study of AZD0780 to reduce heart attack and stroke risk
This trial tests a new medication, AZD0780, to see if it helps prevent major cardiovascular events like heart attacks or strokes in people who already have heart or blood vessel disease, or are at high risk for a first event. It might be a good fit if your cholesterol isn't well-controlled despite current treatments.
Athens, AlabamaAges 18 years+ - NCT07680699Recruiting
Early immunotherapy for high-risk stage II melanoma
This trial tests early anti-PD-1 therapy for people with stage IIB or IIC melanoma, or stage III (N1c). It aims to see if starting treatment sooner helps prevent the cancer from coming back.
São Paulo, São PauloAges 18 years+ - NCT07262840Recruiting
Health behavior change for people at high risk for colorectal cancer
This trial tests a program to help people at high risk for colorectal cancer change their health behaviors to lower their risk. It might help you if you are worried about your risk and want to make positive changes.
Shenyang, LiaoningAges 1.5 years–6.7 years - NCT07262957RecruitingPhase 4
Preventing complications after pancreatic surgery with a drug bundle
This trial tests whether giving a combination of three treatments—hydrocortisone (a steroid), octreotide (a drug that reduces digestive fluids), and a tissue patch—before and during pancreatic surgery can help prevent complications. It is for people with a very small pancreatic duct (3 mm or less) who are scheduled for pancreatic surgery.
AmsterdamAges 18 years+ - NCT07272499RecruitingPhase 2
New drug combo for untreated high-risk mantle cell lymphoma
This trial tests a combination of three drugs (orelabrutinib, lisaftoclax, and rituximab) for people with mantle cell lymphoma who have not had treatment before and have high-risk features. The goal is to see if this combination works better than standard treatments.
Shanghai, Shanghai MunicipalityAges 14 years+ - NCT07277387Recruiting
Predicting complications in high-risk fever with low white blood cells
This trial studies whether proteins in your blood can predict complications when you have a fever and very low white blood cells after cancer treatment. It aims to help doctors choose the best antibiotics early on.
Barcelona, BarcelonaAges 18 years+ - NCT07277686Recruiting
AI face scan for hidden heart disease in high-risk people
This trial tests whether an AI system can detect signs of coronary artery disease (blockages in heart arteries) by analyzing a photo of your face. It may help identify people in the community who need further heart testing.
Zhoukou, HenanAges 18 years+ - NCT07279077RecruitingPhase 2
Low-dose radiation with chemo and immunotherapy for high-risk colon cancer
This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07293715RecruitingPhase 4
Comparing glucose management during labor in type 1 diabetes
This trial looks at two ways to manage blood sugar levels during labor in pregnant people with type 1 diabetes. It aims to find the safest approach for both the patient and the baby.
Columbus, OhioAges 18 years+ - NCT07309029Recruiting
ECMO support during high-risk TAVR heart valve procedure
This trial tests whether placing patients on ECMO (a heart-lung support machine) before a high-risk TAVR valve replacement can improve safety and outcomes. It is for people who are at very high risk due to low blood pressure, severe heart or lung problems, or complex valve anatomy.
Detroit, MichiganAges 18–100 - NCT07316465Recruiting
Tracking immune markers in newborns at risk for eczema
This study follows newborns for two years to see how their immune system develops, especially if they have a family history of eczema, asthma, or hay fever. Researchers want to learn if certain immune markers appear early in babies who later develop eczema.
Jette, Brussels CapitalAges 1 hour–2 years - NCT07321197Recruiting
Kidney removal with or without lymph node removal for high risk kidney cancer
This study is for people with high-risk kidney cancer who are having their whole kidney removed. It compares surgery alone versus surgery plus removing lymph nodes from the tumor area to see if removing the nodes helps control the cancer better.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07322367Recruiting
Mobile program to help you get screened for lung cancer
This study tests a mobile health program to remind and assist you in getting a lung cancer screening scan if you are at high risk. The goal is to make it easier to follow screening guidelines.
Winston-Salem, North CarolinaAges 50–77 - NCT07324720Recruiting
Comparing ischemia vs plaque risk for high-risk artery disease
This trial compares two ways to decide which heart artery blockages need treatment: one looks at blood flow, the other at plaque buildup and risk. It's for people with high-risk blockages to see which approach leads to better outcomes.
Seoul, Main BuildingAges 19 years+ - NCT07325721RecruitingPhase 2
Shorter radiation with a focused boost for high-risk prostate cancer
This trial tests a shorter course of radiation therapy with an extra 'boost' to the most aggressive part of the tumor, combined with hormone therapy, for men with high-risk or locally advanced prostate cancer that has not spread outside the pelvis.
Charleston, South CarolinaAges 18 years+ - NCT07337421RecruitingPhase 2
Chemo infusion after liver cancer surgery to lower recurrence risk
This trial tests whether a targeted chemotherapy infusion directly into the liver's main artery (HAIC) after surgery can prevent liver cancer from coming back. It is for people with certain high-risk features, like a large tumor or cancer in blood vessels, who have had their tumor completely removed.
Yangzhou, JiangsuAges 18–75 - NCT07337460RecruitingPhase 2
Icaritin plus chemotherapy for high-risk liver cancer after surgery
This trial tests combining a natural compound (Icaritin) with standard chemotherapy (mFOLFOX) after liver cancer surgery to lower the chance of the cancer coming back. It is for patients whose cancer had certain high-risk features, like a large tumor or cancer in blood vessels.
Yangzhou, JiangsuAges 18–75 - NCT07339449Recruiting
Monitoring during surgery to reduce time on a breathing tube
This study tests whether special monitors used during major abdominal surgery can help high-risk patients wake up sooner and need a breathing tube for less time after the operation.
Zagreb, CroatiaAges 50 years+ - NCT07501117RecruitingPhase 1
Immunotherapy before eye removal for high-risk eye melanoma
This trial tests immunotherapy before surgery for people with high-risk eye melanoma (uveal melanoma). You’ll get treatment to help your immune system fight the cancer, then have your eye removed. After surgery, you’ll be followed to see how well the treatment worked.
Herlev, HerlevAges 18–80 - NCT07348042RecruitingPhase 1
Study of RGL-270 with or without Adebelimab for high-risk solid tumors
This trial tests a new treatment (RGL-270) alone or with another drug (Adebelimab) to prevent cancer from coming back after surgery. It is for people with solid tumors that have a high chance of returning.
ShanghaiAges 18–75
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 923 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.