Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 826 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06940479Recruiting
Testing a knee procedure for osteoarthritis pain relief
This trial studies changes in joint fluid before and after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. It aims to understand how the procedure works to reduce pain and improve knee function.
Aurora, ColoradoAges 18 years+ - NCT06956222Recruiting
Home vs in-person rehab for knee osteoarthritis
This study compares doing physical therapy exercises at home through a video call (tele-rehab) versus doing them in person at a clinic. It is for people with mild to moderate knee osteoarthritis to see if home rehab works just as well.
JeddahAges 40–80 - NCT06960564Recruiting
Hyaluronic acid injection for knee osteoarthritis
This study tests whether a hyaluronic acid injection (a natural lubricant for joints) can reduce inflammation markers in the knee for people with osteoarthritis. It may be a good option if you have moderate knee pain that hasn't improved with other treatments.
IstanbulAges 45–75 - NCT06971016Recruiting
Mobilization and balance exercises for knee osteoarthritis
This study tests whether a special hands-on technique (Mulligan mobilization) combined with balance exercises can help people with knee osteoarthritis feel better and move easier. It's for people with mild to moderate knee OA who can walk without help.
Karachi, SindhAges 40 years+ - NCT06976138Recruiting
Using Light or ions to Improve Sleep and Pain After Knee Surgery
This study tests whether a special bright light or negative ion therapy can help older adults sleep better and have less pain after knee replacement surgery. It's for people with knee arthritis who already have trouble sleeping and are scheduled for one knee replacement.
Baltimore, MarylandAges 60 years+ - NCT06999057RecruitingEarly Phase 1
Knee injury study for healthy active adults
This trial studies how your thigh muscle adapts after a simulated knee injury. It uses mild electrical stimulation and a small needle to measure muscle signals, and may help improve recovery after knee injuries.
Orlando, FloridaAges 18–30 - NCT07002580Recruiting
Knee surgery pain relief: nerve block comparison
This study compares two types of nerve blocks (iPACK and adductor canal block) to see which provides better pain relief after arthroscopic knee surgery. It may help you have less pain and recover faster.
SakaryaAges 18–50 - NCT07016243Recruiting
Knee recovery and ankle movement after knee replacement
This study looks at how well patients can move their ankle after knee replacement surgery and whether it affects their knee recovery. It may help improve rehabilitation for future patients.
Bagheria, PalermoAges 65–85 - NCT07057063Recruiting
Light therapy for knee pain and swelling
This study tests if light therapy can reduce knee pain and swelling (synovitis) caused by arthritis. If you have long-lasting knee pain and arthritis, this treatment might offer a non-drug option to help you feel better.
ShenzhenAges 40–80 - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+ - NCT07078877Recruiting
Laser therapy for knee osteoarthritis: a new option?
This study tests whether low-level laser therapy (a painless, non-surgical treatment using light) can reduce knee pain and improve knee function, cartilage health, and muscle strength in people with moderate knee osteoarthritis. It may be an option if you haven't had recent knee injections or physical therapy.
Ankara, YENIMAHALLEAges 50 years+ - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT07105657Recruiting
Rehabilitation after hip or knee replacement
This trial tests if three weeks of intensive rehabilitation helps people who still have physical problems after a total hip or knee replacement. It aims to improve your recovery and function.
BrædstrupAges 18 years+ - NCT07109557Recruiting
Baduanjin for recovery after knee replacement
This study tests whether doing Baduanjin, a gentle mind-body exercise, helps people recover better after knee replacement surgery. It focuses on patients who are in stable condition and willing to try the exercise.
YalovaAges 18–70 - NCT07110324Recruiting
Understanding long-term pain after hip or knee replacement
This study looks at people who still have moderate to severe pain months after a hip or knee replacement. The goal is to learn more about what causes this pain and how it feels, which could help improve future treatments.
Østerbro, København ØAges 18 years+ - NCT07140367Recruiting
Artery treatment for inflammatory knee arthritis
This trial tests if a minimally invasive procedure that blocks small arteries can reduce pain and swelling in arthritic knees. It's for people with moderate knee osteoarthritis who still have pain after trying other treatments and are already considering knee replacement surgery.
Bologna, BolognaAges 40 years+ - NCT07145645RecruitingPhase 3
Comparing topical diclofenac to oral ibuprofen for pain from ankle or knee injuries in children
This study compares a topical gel (diclofenac) applied directly to the injury site versus an oral medication (ibuprofen) taken by mouth to see which works better for treating pain from ankle or knee injuries in children. It may offer a way to relieve pain without a pill.
Calgary, AlbertaAges 6–18 - NCT07166068Recruiting
Movement therapy for knee osteoarthritis inflammation
This study tests whether specific mobilization exercises can reduce inflammation in people with knee osteoarthritis. It aims to see if these movements help lower markers of inflammation and improve pain.
Jizan, Jazan RegionAges 18 years+ - NCT07168590Recruiting
Knee X-ray and its link to pain and fear of movement in osteoarthritis
This study looks at whether the shape of your knee on an X-ray is related to how much pain you feel and how afraid you are of moving. It may help doctors better understand knee osteoarthritis.
IstanbulAges 18 years+ - NCT07198555RecruitingPhase 1
Study of BBM-A101 for knee osteoarthritis
This trial tests a new medicine called BBM-A101 for people with moderate knee osteoarthritis. It aims to see if it is safe and helps reduce pain and improve function.
Shenzhen, GuangdongAges 40–75 - NCT07201597Recruiting
Readiness and knee function after ACL surgery
This study looks at how your mental readiness, knee function, and strength relate after ACL reconstruction using a specific type of tendon graft. It may help you understand if you're ready to return to sports.
Cairo, Cairo GovernorateAges 18–35 - NCT07212777Recruiting
Custom vs standard knee surgery for knee alignment
This study compares a custom 3D-printed surgical guide to the standard technique for a knee realignment surgery called high tibial osteotomy. It is for people with knee arthritis on the inner side of the knee who have not improved with other treatments.
MálagaAges 18–70 - NCT07219771RecruitingPhase 3
Testing MOTYS injection for knee osteoarthritis pain
This trial tests an injection called PTP-001 (MOTYS) for people with mild to moderate knee osteoarthritis. It aims to see if the injection can reduce knee pain and improve function.
Birmingham, AlabamaAges 40–80 - NCT07238751Recruiting
Bowen technique and backward walking for knee osteoarthritis
This study tests whether the Bowen technique (a gentle hands-on therapy) combined with walking backward can improve hamstring flexibility and reduce pain in people with knee osteoarthritis. It may help if you have tight hamstrings and mild to moderate knee arthritis.
Islamabad, Punjab ProvinceAges 40–60
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 826 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.