Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 819 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06172010RecruitingPhase 4
Rifampicin plus antibiotics for staph joint replacement infection
This study tests whether adding the antibiotic rifampicin to standard treatment works better than standard treatment alone for staph infections in hip or knee replacements. The goal is to find a more effective way to clear the infection and avoid more surgeries.
Leiden, Zuid HollansAges 18 years+ - NCT06249906Recruiting
Bioceramic material for bone defect repair
This trial tests a new bioceramic material to repair bone defects. It is for adults aged 18 to 65 who are generally healthy and can follow the study plan.
Nanjing, JiangsuAges 18–65 - NCT06249958Recruiting
Personalized rehabilitation after hip or knee replacement
This study looks at how personalized rehabilitation after hip or knee replacement surgery can improve your quality of life. It is for people who had their surgery at IRCCS Galeazzi Orthopedic Institute in 2019.
Milan, ItaliaAges 18 years+ - NCT06267482RecruitingPhase 4
Using a robot for knee replacement surgery
This trial tests if a robot-assisted device (ROSA) helps with challenging knee replacements. It compares it to the standard surgery for people with mild knee bowing who need a first-time knee replacement.
London, OntarioAges 21–80 - NCT06311513RecruitingPhase 4
Concentrated bone marrow injection during repeat ACL surgery
This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
Atlanta, GeorgiaAges 18–55 - NCT06320925Recruiting
SportsPro study after joint surgery
This study follows patients who had joint repair with specific Stryker devices to see how well the procedure works in daily life.
Phoenix, ArizonaAges 18 years+ - NCT06330493Recruiting
Study of a drug-coated balloon for leg artery disease
This trial tests a special balloon coated with medication to open up blocked arteries below the knee in people with serious leg circulation problems. It aims to improve blood flow and avoid amputation.
Concord, CaliforniaAges 18 years+ - NCT06336447Recruiting
Virtual reality and nerve block for chronic knee pain
This study tests whether using virtual reality (VR) before a standard heat-based nerve block (radiofrequency ablation) can improve relief of long-term knee pain caused by arthritis. If you qualify, you'll receive the RFA procedure and may be randomly assigned to also use VR.
Chicago, IllinoisAges 18 years+ - NCT06368544Recruiting
Early walking training after ACL knee surgery
This trial studies whether starting walking exercises earlier after ACL reconstruction can help protect the knee cartilage from wearing down. It may be a good fit if you are having your first ACL surgery at Peking University Third Hospital and your knee has already healed from the initial injury.
BeijingAges 18–40 - NCT06370312Recruiting
Biomarkers for thumb osteoarthritis surgery
This study looks at joint fluid and tissue samples from people with thumb base osteoarthritis who are already scheduled for a surgery called trapeziectomy. The goal is to find markers that might help better understand the disease and improve treatment.
Malmö, Skåne CountyAges 25 years+ - NCT06388811Recruiting
Turkish version of a knee pain questionnaire study
This study tests a Turkish questionnaire for early knee osteoarthritis. It may help doctors better identify and treat early knee pain.
IstanbulAges 18 years+ - NCT06426251Recruiting
Light therapy for knee replacement recovery
This trial tests whether a special light therapy (photobiomodulation) can help reduce pain and speed healing after total knee replacement. If you're having knee replacement and don't have complications like infection or open wounds, you may be eligible.
HsinchuAges 20 years+ - NCT06462040Recruiting
Dissolving Screws for Loose Knee Cartilage
This study follows patients who have a loose piece of bone and cartilage in their knee and are having it fixed with special screws that dissolve over time. The goal is to see how well the knee heals and works after surgery.
Bologna, BolognaAges 12–35 - NCT06466850Recruiting
Stem cell exosomes for knee osteoarthritis
This trial studies whether a natural substance called exosomes, derived from stem cells, can help reduce pain and improve function in people with knee osteoarthritis. It may be an option if other treatments have not worked well for you.
IsfahanAges 45–75 - NCT06474182Recruiting
Apixaban for blood clots in myeloma patients
This study looks at how Apixaban (a blood thinner) works in people with newly diagnosed multiple myeloma. It compares them to people having knee replacement surgery. The goal is to see if the drug prevents clots effectively in both groups.
Saint-EtienneAges 18 years+ - NCT06477965Recruiting
Registry for artery embolization to treat chronic pain
This is a registry study that gathers information from people who have had an artery embolization procedure to treat long-term pain from conditions such as arthritis. The goal is to track outcomes and better understand the procedure's effectiveness.
Cary, North CarolinaAges 18 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT06507241Recruiting
Knee meniscus root tear repair using ligament suture
This trial tests a surgical technique to fix a certain type of meniscus tear (called a root tear) by stitching it to the knee's posterior cruciate ligament. The goal is to see if this approach helps patients recover better.
BolognaAges 18–50 - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT06504953Recruiting
Knee movement study in women with and without hormone therapy
This study measures knee movement in healthy women ages 18-40 to see if hormone therapy affects it. You will need to come in on a specific day of your menstrual cycle.
Nice, Alpes-MaritimesAges 18–40 - NCT06505525Recruiting
ACL reconstruction: adding extra support vs standard surgery
This trial compares two surgical techniques for ACL reconstruction. The standard method repairs the ACL inside the knee joint, while the new method also adds extra support outside the joint. The study aims to see which approach gives better stability and recovery for people with specific risk factors, like being a young athlete or having a chronic ACL tear.
São Paulo, São PauloAges 14–40 - NCT06522087Recruiting
40 Hz brain stimulation to prevent confusion after hip or knee replacement
This trial tests if a non-invasive 40 Hz brain stimulation can prevent delirium (sudden confusion) in older adults after hip or knee replacement surgery. Delirium is common after surgery in elderly patients, and this treatment aims to lower that risk.
Zhengzhou, HenanAges 65–85 - NCT06522620Recruiting
Nerve block for knee pain after total knee replacement
This trial tests whether a nerve block can reduce pain on the back and outer side of the knee after total knee replacement surgery. If effective, it may help you recover more comfortably.
Yinchuan, NingxiaAges 45–80 - NCT06529692Recruiting
Split-belt treadmill training after ACL reconstruction
This study tests whether walking on a special split-belt treadmill (where each belt moves at a different speed) can help improve how your knee moves and feels after ACL reconstruction. The goal is to see if this training leads to better long-term knee health.
Ann Arbor, MichiganAges 14–45
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 819 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.