Clinical trials
Large Ischemic Core clinical trials
Below are recruiting large ischemic core clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07090941Recruiting
Clot removal for severe basilar artery stroke
This trial tests a procedure to remove a blood clot from the main artery at the back of the brain (basilar artery) in people who have a large stroke. The goal is to see if this treatment can improve recovery even when the stroke damage is bigger than usual.
Haikou, HainanAges 18 years+ - NCT07345702Recruiting
Endovascular therapy for large core posterior stroke
This trial tests endovascular therapy (a procedure to remove a clot through a tube in an artery) versus medical management for people with a severe stroke due to a blockage in the back part of the brain (basilar artery) and a large area of brain damage. The goal is to see if the procedure improves outcomes compared to medication alone.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06210633Recruiting
Clot removal trial for very large strokes
This trial tests a procedure called endovascular thrombectomy (clot removal through a catheter) for people with very large strokes. It aims to see if removing the clot can help even when a large part of the brain is already damaged.
Xiangtan, HunanAges 18 years+ - NCT07202143RecruitingPhase 3
Steroid treatment for severe stroke with low lymphocyte count
This trial tests if the steroid methylprednisolone helps people who have had a major stroke and also have low infection-fighting white blood cells (lymphocytes). It is for patients who are getting a procedure to remove the clot (thrombectomy) within 24 hours of the stroke.
Fuzhou, FujianAges 18 years+ - NCT06388148Recruiting
Clot removal for very large strokes
This trial tests a procedure to remove a large blood clot in the brain (mechanical thrombectomy) for people who have a very large stroke. It aims to see if removing the clot can improve recovery, even for those with severe strokes.
Hengyang, HunanAges 18 years+ - NCT06155032Recruiting
Clot Removal for Worsening Mild Stroke
This trial tests whether emergency clot removal (endovascular therapy) can help people whose mild stroke gets worse within a week. It's for those who have a blockage in a large brain artery and enough healthy brain tissue to save.
Fuyang, AnhuiAges 18 years+ - NCT06211712Recruiting
Drug plus clot removal for large vessel stroke
This study tests whether adding a drug called human urinary kallidinogenase to standard clot-removal therapy helps people recover better after a large-vessel stroke. If you qualify, you would receive the drug or a placebo by IV along with the procedure, and doctors will monitor your recovery.
ShanghaiAges 18 years+ - NCT07174505Recruiting
Study of the CONDA Stent Retriever for stroke patients
This trial tests a device called the CONDA Stent Retriever to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. It may help if you can be treated within 24 hours of symptoms starting and meet specific brain scan and health criteria.
BudapestAges 18–85 - NCT06961487Enrolling by invitation
Stroke treatment trial for large area brain damage
This trial tests if a procedure to remove a large blood clot from the brain (called a thrombectomy) can help people with severe strokes who have a large damaged area. It is for people who can be treated within 24 hours of their stroke starting.
Palo Alto, CaliforniaAges 18–90 - NCT07727395RecruitingPhase 3
Clot-busting drug after successful clot removal for stroke
This trial tests whether giving a clot-busting drug (alteplase) directly into the brain artery after a successful clot removal improves recovery in people with severe stroke. It is for patients who have had a thrombectomy and still have a large blocked artery in the front of the brain.
An GiangAges 18 years+ - NCT07253181RecruitingPhase 3
Stroke clot-busting drug before transfer for artery clearing
This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06301412RecruitingPhase 3
Cooling plus clot removal for acute stroke
This trial tests whether cooling the body down (hypothermia) combined with a clot removal procedure (thrombectomy) helps people recover better from a large-artery stroke. You may be eligible if you have a moderate-to-severe stroke and can be treated within 24 hours of when you were last seen well.
Freiburg im BreisgauAges 18 years+ - NCT06629116Recruiting
Albumin treatment for large strokes after thrombectomy
This trial tests if giving a protein called albumin after a large stroke can improve recovery. Albumin may help reduce brain swelling and damage. You may qualify if you had a large stroke in the front part of the brain, got a clot-removal procedure, and meet certain age and health criteria.
Zhangzhou, FujianAges 18–80 - NCT06904911RecruitingPhase 2
Study of tenecteplase into the artery after clot removal for stroke
This study tests a clot-dissolving drug called tenecteplase given directly into the artery after a mechanical thrombectomy (clot removal). The goal is to see if it helps improve blood flow to the small vessels in the brain after the main clot is removed.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07740018Recruiting
Stroke treatment study for blocked brain arteries
This study looks at how well a procedure to remove blood clots from blocked brain arteries works for people who have had a stroke. It aims to see what factors help people recover better, which could help guide treatment decisions.
SohagAges 18–80 - NCT06374667Recruiting
Skull bone injection vs. IV for large stroke
This trial tests a new way to give medicine for a large stroke on one side of the brain. The medicine is injected into the skull bone instead of through a vein, and researchers want to see if it works better and is safe.
Wuhu, AnhuiAges 18–80 - NCT06781385Enrolling by invitationPhase 2
Tenecteplase after clot removal for severe stroke
This trial tests if giving a clot-busting drug (tenecteplase) directly into the brain artery after a successful clot-removal procedure can improve outcomes for people with a major stroke. It is for patients who had a large vessel blockage and received endovascular thrombectomy within 24 hours of symptoms starting.
Charlotte, North CarolinaAges 18 years+ - NCT06959199Recruiting
Treating stroke beyond 24 hours with artery-opening procedure
This study tests whether opening a blocked large artery in the brain up to 5 days (or even 7 days if symptoms are worsening) after a stroke can improve outcomes. It uses a catheter-based treatment (endovascular therapy) for people who have not responded to standard care and have limited brain damage so far.
Hefei, AnhuiAges 18 years+ - NCT05199662RecruitingPhase 3
IV clot-busting medicine for stroke when standard options don’t fit
This trial tests whether giving IV TNK (tenecteplase) plus standard stroke care can improve outcomes in some people who have a new stroke but cannot get alteplase (another clot-busting drug) and do not have a large blocked artery that can be treated with a procedure. It’s meant for strokes with “mismatch” findings on scans that suggest salvageable brain tissue.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06472336Recruiting
Stenting for severe stroke caused by plaque buildup
This trial tests whether placing a stent (a tiny tube) in the blocked artery in the brain can improve blood flow and help people recover from a severe stroke, especially when standard clot removal has not worked.
Basel, Canton of Basel-CityAges 18 years+ - NCT05326932Recruiting
Extended-Time Thrombectomy for Large-Artery Stroke
This trial studies whether a mechanical procedure to remove a blocked artery can help people with an ischemic stroke caused by a large artery blockage, even when treatment starts 24–72 hours after symptoms began. It also checks that only patients with “salvageable” brain tissue on CT scans are treated.
ShanghaiAges 18 years+ - NCT07356284RecruitingPhase 3
Stroke treatment study for blocked arteries with narrowing
This study tests a rescue treatment for people having a major stroke caused by a blocked artery in the brain that also has severe narrowing. If doctors can't fully open the artery with standard clot removal, this study looks at whether additional treatments can help.
Toledo, OhioAges 18–80
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Common questions
- Are there clinical trials for large ischemic core?
- Yes. Clin2 currently lists 22 recruiting large ischemic core studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a large ischemic core trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a large ischemic core trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.