Clinical trials
Metastases clinical trials
Below are recruiting metastases clinical trials, each written for real people, not researchers. We’re tracking 450 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04218617RecruitingPhase 2
One vs two radiation treatments for spine metastases
This trial tests whether giving radiation to a spine metastasis in one dose works as well as giving it in two smaller doses. It aims to control tumors while keeping side effects and risk to the spinal cord low.
Cleveland, OhioAges 18 years+ - NCT04143516RecruitingPhase 2/Phase 3
Test tissue testing right after liver tumor ablation
This study looks at liver metastases treated with a procedure that destroys tumors (ablation) and then checks tumor tissue right away. The team wants to see whether the tissue results can guide immediate retreatment to better control cancer in the liver.
New York, New YorkAges 18 years+ - NCT04020276Recruiting
Adaptive MRI radiation for liver metastases
This study tests a radiation treatment that uses real-time MRI (an imaging scan) to guide the dose for liver metastases. It may help control tumors while aiming to better protect nearby healthy liver tissue.
Madison, WisconsinAges 18 years+ - NCT03550391RecruitingPhase 3
Surgery-like brain radiation vs avoiding the memory center
This trial compares two ways of giving radiation to the brain for people with 5 or more brain metastases: focused stereotactic radiosurgery, or a whole-brain approach that tries to spare the memory area (with memantine). It aims to see which method better protects thinking and memory while still treating the tumors.
Tucson, ArizonaAges 18 years+ - NCT03449238RecruitingPhase 1/Phase 2
Pembrolizumab with focused brain radiation for breast cancer brain spread
This trial studies whether pembrolizumab (an immune therapy medicine) plus stereotactic radiosurgery (focused radiation) can better control brain metastases from breast cancer. It may help shrink or slow growth of multiple brain spots with minimal treatment to surrounding tissue.
New York, New YorkAges 19–90 - NCT02747303RecruitingPhase 2
Focused radiation for 1 to 5 brain metastases without surgery
This Phase 2 study tests a precise, no-head-frame radiation technique to treat brain metastases. It may help by aiming radiation tightly at the tumors while limiting exposure to nearby healthy brain.
Chicago, IllinoisAges 18 years+ - NCT02172651RecruitingEarly Phase 1
Vitamin D during early colon cancer or liver surgery
This trial studies whether taking higher-dose vitamin D3 around the time of colon cancer (or colon cancer with resectable liver metastases) surgery improves outcomes. It focuses on safety and possible effects on cancer-related health after surgery.
Boston, MassachusettsAges 18 years+ - NCT02356497Recruiting
Study of treatments for bone metastases using routine data
This study follows adults with cancer that has spread to the bones and who are receiving radiation treatment. It looks at how interventional (procedure-based) treatment decisions affect outcomes by using information collected during routine care.
Utrecht, UtrechtAges 18 years+ - NCT02390518RecruitingPhase 1
Tested different radiation doses for brain metastases
This Phase 1 study tests how to safely give focused radiation (SRS) at different doses to people with brain metastases. It aims to find a dose level that works well while limiting side effects.
Salt Lake City, UtahAges 18 years+ - NCT01697371Recruiting
Proton beam radiation for liver metastases
This trial tests whether proton beam therapy can control cancer that has spread to the liver. It may help shrink liver tumors or slow their growth while aiming to reduce harm to nearby organs.
Loma Linda, CaliforniaAges 18 years+ - NCT07085442Recruiting
Audit of targeted lymph node biopsy for early breast cancer
This study looks at how well a special type of lymph node biopsy works for people with early breast cancer that has spread to a small number of lymph nodes. It aims to see if this approach is effective and safe, which may help guide future treatment decisions.
BurnleyAges 18 years+ - NCT07619534Recruiting
Collecting Spinal Fluid from Advanced Breast Cancer Patients
This study collects spinal fluid samples from people with advanced (metastatic) HER2-positive or triple-negative breast cancer who have never had, and currently do not have, cancer spread to the brain. Researchers want to understand how cancer cells might reach the nervous system and develop better treatments.
Bethesda, MarylandAges 18–120 - NCT06391242RecruitingPhase 3
Comparing radiation treatments for painful bone metastases
This trial compares two types of radiation therapy—standard palliative radiation and a more targeted high-dose treatment (SBRT)—to see which better relieves pain from bone metastases that have spread outside the spine. It is for people with solid tumors who have a painful bone spot and are expected to live at least 6 months.
Calgary, AlbertaAges 18 years+ - NCT03392233RecruitingPhase 2
Targeted radiation for spinal metastases causing significant pain
This trial tests a focused form of radiation (stereotactic body radiation) to treat cancer spread to the spine, especially when it causes substantial pain. It may help shrink or control the spinal spots while limiting damage to surrounding tissues.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT05240950RecruitingPhase 1
CAR-T cell therapy for colorectal cancer in the liver
This Phase 1 study tests an anti-CEA CAR-T cell treatment for people whose colorectal cancer spread to the liver but has been surgically removed with no visible remaining tumor. It aims to see if the treatment can better prevent the cancer from coming back, especially when early warning tests suggest leftover cancer cells.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05375591Recruiting
AI study to sort lung nodules after past cancer treatment
This study uses computer tools (AI) and detailed scan patterns to better classify new lung nodules in people who previously had curative-intent cancer treatment. It may help doctors decide whether a nodule is likely benign or cancer, using your CT scan and related medical history.
LondonAges 18 years+ - NCT04403867Recruiting
Study of tiny cancer spread found in sentinel lymph nodes
This trial studies whether very small deposits of cancer (called micrometastasis or isolated tumor cells) are found in sentinel lymph nodes in early endometrial or cervical cancer. The goal is to better understand what these findings may mean for cancer spread and treatment planning.
MilanAges 18 years+ - NCT04486495Recruiting
Minimally invasive lymph node treatment after chemo for node-positive breast cancer
This study looks at a less invasive way to check and treat lymph nodes in the armpit after you receive chemotherapy (and sometimes immunotherapy) before breast surgery. It may help people with cancer that has already spread to armpit lymph nodes by improving how staging and treatment are done.
's-HertogenboschAges 18 years+ - NCT03280511RecruitingPhase 2
After surgery chemo sprayed into the abdomen for high-risk colon cancer
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
OdenseAges 18 years+ - NCT05722275Recruiting
Predicting peritoneal spread in advanced stomach cancer
This trial uses CT scan images and a look inside the abdomen (laparoscopy) to predict whether advanced stomach cancer has spread to the lining of the abdomen (the peritoneum). It may help your care team better identify who already has peritoneal spread and who might not.
BeijingAges 18 years+ - NCT05354596Recruiting
SBRT radiation trial for central lung tumors
This trial studies a focused, high-dose radiation treatment called SBRT for lung tumors that are hard to operate on, including very central tumors near major airways or organs. It may help people control tumor growth while limiting radiation exposure to nearby critical structures.
AalborgAges 18 years+ - NCT05800223RecruitingPhase 3
Armatinib with or without brain radiation for EGFR lung cancer
This study tests whether armatinib alone or combined with focused brain radiation (SRT) can control brain metastases from EGFR-mutated non-small cell lung cancer. It aims to improve outcomes for people with few, mostly low-symptom brain spots.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05815082RecruitingPhase 3
ctDNA-guided chemo after liver surgery for colon cancer
This trial checks whether giving chemotherapy after surgery only for people whose blood test (ctDNA) shows no remaining cancer can help prevent the cancer from coming back. It is for people with colon cancer that has spread to the liver who had the tumor fully removed.
Guangzhou, GuangdongAges 18–75 - NCT04805255Recruiting
Study brain-targeted radiation for limited brain metastases
This study looks at people with a small number of brain metastases who are treated with a focused, staged form of radiation after surgery or to treat the cancer. It may help doctors better understand how well this approach works and who benefits most.
TaoyuanAges 18–84
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Common questions
- Are there clinical trials for metastases?
- Yes. Clin2 currently lists 450 recruiting metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.