Clinical trials
Mitral Valve Stenosis clinical trials
Below are recruiting mitral valve stenosis clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07726173Recruiting
Off-pump mitral valve repair through the heart
This trial tests a new way to repair a leaky mitral valve without stopping the heart or using a heart-lung machine. The surgery is done through a small cut in the heart's lower chamber. It may be an option for people with severe degenerative mitral regurgitation who are not good candidates for standard open-heart surgery.
Baltimore, MarylandAges 21 years+ - NCT04893603Recruiting
TAVR valve test for severe, hard-to-pump heart valve
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
BeijingAges 70 years+ - NCT05909748Recruiting
First-in-human test of a new TAVR valve for severe aortic narrowing
This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.
Petah TikvaAges 18–120 - NCT04913727Recruiting
Testing heart scan predictions after mitral valve repair
This trial studies severe secondary mitral valve leaking and uses heart imaging to predict how well the heart and symptoms improve after a less-invasive valve procedure. It may help doctors better forecast who benefits most from this repair.
BernAges 18 years+ - NCT03972644Recruiting
Early valve replacement for people with severe but silent aortic narrowing
This trial tests whether replacing a badly narrowed aortic valve earlier—even when you feel fine—can prevent future heart problems. It compares early valve replacement (through a catheter or surgery) versus standard watchful waiting.
Odense, FynAges 18–85 - NCT06552689Recruiting
Testing Sutra Hemi-valve for leaky mitral valve
This trial tests a new, less invasive heart valve (Sutra Hemi-valve) for people with a leaky mitral valve who cannot have standard surgery. The valve is delivered through a vein in your leg, so you avoid open-heart surgery.
HamiltonAges 18 years+ - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Birmingham, AlabamaAges 18 years+ - NCT05927441Recruiting
Heart valve repair/stenting test for leaky mitral valve
This study tests a catheter-based procedure to treat a leaky mitral valve (either FMR or DMR, depending on the group you’re in). It may help reduce symptoms and improve heart function in people who are sick from valve leakage but are able to undergo this specific approach.
BonnAges 18 years+ - NCT07145463Recruiting
New delivery system for severe aortic stenosis treatment
This trial tests a new delivery system (VitaFlow Liberty Flex) for placing a replacement aortic valve in people with severe aortic stenosis. It is designed for patients whose heart anatomy (a steep angle between the heart and aorta) makes the procedure more challenging.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05655897Recruiting
Clips for leaky mitral valve in high-surgery-risk heart patients
This trial studies whether a device called GeminiOne can safely and effectively repair a leaky mitral valve using a catheter-based “clip” technique. It may help patients who have moderate-to-severe or severe valve leakage but are considered too high-risk for open surgery.
Suzhou, JiangsuAges 18 years+ - NCT06518681Enrolling by invitation
Testing a new polymer heart valve for aortic disease
This trial tests a new type of artificial heart valve made of polymer (a special plastic-like material) for people with severe aortic valve disease. It aims to see if the valve is safe and works well, giving you an option for a replacement valve that might last longer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07335900Recruiting
Studying heart healing after TAVI with FAPI-PET scan
This study uses a special type of PET scan (FAPI-PET) to see how the heart heals after a less invasive valve replacement procedure called TAVI. It aims to help doctors better understand the changes in heart tissue after treatment for aortic stenosis.
ShanghaiAges 18 years+ - NCT04343313Recruiting
Transcatheter repair for leaky mitral valve in high-risk adults
This pilot study tests a newer catheter-based way to reduce leakage of the mitral valve in people who feel sick from mitral regurgitation but are considered too high-risk for standard surgery. If you fit the valve and heart anatomy needs, the study may help improve symptoms and valve function without open-heart surgery.
New York, New YorkAges 21–95 - NCT04029363Recruiting
Transcatheter mitral valve procedure for high-surgery-risk patients
This trial studies a newer, catheter-based mitral valve treatment in people with moderate-severe to severe mitral valve leaking who are at high risk for open-heart surgery. It may help improve symptoms and heart function without traditional surgery, but you must meet key heart, anatomy, and safety requirements.
Darlinghurst, New South WalesAges 18 years+ - NCT06414265Recruiting
Testing a new valve for severe mitral regurgitation
This trial tests a new device called the SATURN system, which places a new mitral valve without open-heart surgery. It is for people aged 65 and older with severe mitral regurgitation who are at high risk for surgery.
TbilisiAges 65 years+ - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Gilbert, ArizonaAges 18 years+ - NCT07188233Recruiting
Catheter repair for leaky mitral valve in heart failure
This trial tests a new device (CathHELIX) placed through a vein to repair a leaky mitral valve in people with heart failure. It is for people with moderate to severe mitral regurgitation who still have symptoms despite medical therapy.
Tbilisi, GeorgiaAges 18 years+ - NCT06596460Recruiting
Imaging study after TAVI valve replacement
This study collects extra imaging data from 40 people who are already scheduled for a routine TAVI procedure to replace a narrowed aortic heart valve. The goal is to better understand the valve's structure and function using scans.
London, EnglandAges 18 years+ - NCT02925819Recruiting
Study for severe mitral valve disease when surgery isn’t an option
This trial focuses on people with severe mitral valve narrowing or leaking who still have symptoms even after the best usual medications. It may help find better care and measure health outcomes when surgery is judged too risky or not suitable.
LyonAges 18 years+ - NCT03003299Recruiting
Valve replacement for failing aortic bioprosthetic valves
This trial studies a new “valve-in-valve” procedure to treat a failing aortic bioprosthetic valve. It may help people improve blood flow through the heart valve and reduce valve-related problems.
Phoenix, ArizonaAges Any age - NCT04913870RecruitingPhase 4
Tested blood pressure pills for mild to moderate aortic narrowing
This study tests whether angiotensin receptor blocker (ARB) blood pressure medication helps people with mild to moderate aortic stenosis (a narrowing of the heart’s main valve). It looks at safety and whether the treatment offers benefit for your heart and blood flow.
Québec, QuebecAges 20–99 - NCT07001800RecruitingPhase 2/Phase 3
Slowing aortic valve disease with ataciguat
This trial tests a new pill, ataciguat, to slow down the progression of moderate calcific aortic valve stenosis (a condition where your aortic valve stiffens). If you have moderate valve narrowing and meet the other criteria, participation could help find a way to delay needing surgery.
Birmingham, AlabamaAges 50 years+ - NCT05610566Recruiting
HighLife valve replacement for severe leaking mitral valve
This trial studies a new catheter-based valve replacement system for people with moderate to severe, or severe, mitral valve regurgitation (a leaky mitral valve). It aims to check whether the procedure is safe and can improve heart function compared with expected care.
Suzhou, JiangsuAges 18 years+ - NCT04888247Recruiting
Testing a new mitral valve replacement for high-risk patients
This study checks whether an innovative device can safely replace a damaged mitral valve in people who are higher risk for open-heart surgery. It looks at how well the procedure and follow-up work for improving mitral leakage symptoms.
AuchenflowerAges 18 years+
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Common questions
- Are there clinical trials for mitral valve stenosis?
- Yes. Clin2 currently lists 86 recruiting mitral valve stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral valve stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral valve stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.