Clinical trials
Muscle Atrophy or Weakness clinical trials
Below are recruiting muscle atrophy or weakness clinical trials, each written for real people, not researchers. We’re tracking 166 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05536531Recruiting
NMES therapy to help prevent ICU muscle weakness
This trial tests whether a device that delivers small electrical pulses to muscles can help prevent breathing and muscle weakness in very sick ICU patients. It also looks at changes in blood markers that may relate to muscle weakness and recovery.
Santiago, Santiago MetropolitanAges 18 years+ - NCT05206838Recruiting
Treating gluteus medius tendon weakness after hip replacement
This trial looks at treating a specific hip muscle-tendon problem (gluteus medius insufficiency) after total hip replacement. It may help people who have had ongoing limping despite surgery by using an Achilles tendon–based approach.
MölndalAges 40–80 - NCT05216666Recruiting
Surgery type and leftover limping after hip replacement
This study looks at whether the kind of hip surgery approach affects how much limping remains after a total hip replacement. You may benefit by helping researchers find the approach that leads to better walking after surgery.
MölndalAges 40–80 - NCT05919940Recruiting
Testing a muscle stimulation and extra protein plan in ICU patients
This trial tests whether electrical muscle stimulation plus extra protein (protein substitute) can improve muscle health and metabolism in critically ill adults in the ICU. If you’re newly admitted and expected to stay on a breathing machine for several days, it may help you keep more muscle strength during recovery.
Vienna, State of ViennaAges 18 years+ - NCT06631053Recruiting
Exercise program for 30 days of leg muscle disuse
This study looks at how a specific exercise program affects your muscles after a period of not using them (simulated by a leg brace). You'll wear a brace on one leg for 30 days and do certain exercises to see if they help prevent muscle loss.
Lexington, KentuckyAges 35–45 - NCT06185179RecruitingEarly Phase 1
Metformin for muscle recovery in older adults
This study tests whether a common diabetes medicine called metformin can help your muscles recover faster after a minor injury. You may qualify if you are 60 or older, generally healthy, and not taking certain medicines.
Salt Lake City, UtahAges 60 years+ - NCT07597850RecruitingPhase 2
TCM formula versus HMB supplement for muscle strength in older adults
This study compares a traditional Chinese medicine formula with HMB (a muscle-building supplement) to see which helps preserve muscle strength and bone health in adults aged 65 and older who are starting to show signs of frailty. Both treatments aim to help you stay stronger and more active as you age.
TaipeiAges 65 years+ - NCT05926219Recruiting
Study C-protein changes with fatigue and aging
This study looks at how a blood protein called C-protein relates to fatigue and aging, and how exercise affects it. You may be able to join if you’re otherwise healthy and willing to do muscle testing and activity monitoring.
Eugene, OregonAges 18–80 - NCT07171346Enrolling by invitation
Muscle stimulator after ACL reconstruction
This study tests whether a special muscle-stimulating device worn after ACL reconstruction surgery can help your knee recover strength faster. If you qualify, you will use the device at home for a few weeks and your recovery will be checked regularly.
Kansas City, KansasAges 15–50 - NCT04057833Enrolling by invitationPhase 1
Cell treatment added to rotator cuff repair surgery
This Phase 1 study tests whether an added cell therapy (E-CEL UVEC cells) can improve healing after arthroscopic (keyhole) rotator cuff repair. It may help people with a specific type of tendon tear who have not improved with standard treatments.
New York, New YorkAges 45–70 - NCT07362862Recruiting
Electrical muscle stimulation to prevent ICU weakness
This trial tests a wearable device that uses mild electrical pulses to stimulate leg muscles, helping prevent muscle weakness in ICU patients with severe infections. It may help you recover strength faster and avoid long-term disability.
Rochester, MinnesotaAges 18–85 - NCT06253104Recruiting
Tracking muscle changes in acute heart failure
This study measures how thigh muscles change in people hospitalized with severe heart failure. It aims to understand muscle loss during this condition and how it relates to recovery.
Boston, MassachusettsAges 18–100 - NCT07688863Enrolling by invitation
Comparing breathing muscle training methods for heart failure
This trial compares two different types of breathing muscle training to see which works better for people with heart failure and weak breathing muscles. You may join if you have heart failure with reduced pumping ability and are stable overall.
Viña del Mar, ValparaisoAges 18 years+ - NCT07147933Recruiting
Treatment for crouch gait in cerebral palsy
This trial tests a treatment for children with cerebral palsy who have a crouched walking pattern, a forward-tilted pelvis, and weak calf muscles. It uses EMG to check muscle activity and aims to improve walking.
AmmanAges 4–10 - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT07531719Recruiting
Risdiplam treatment study for type I and II spinal muscle atrophy
This study follows children with spinal muscular atrophy (SMA)—a genetic condition causing muscle weakness—who are being treated with a medicine called risdiplam. Researchers want to understand how well the treatment works and how it affects daily life in young patients.
CairoAges Up to 5 years - NCT03761446Recruiting
Testing how diabetes affects muscle loss after bed rest
This study looks at how pre-diabetes or type 2 diabetes may change skeletal muscle loss and recovery in older adults after a period of bed rest. It may help researchers understand why recovery can be slower and how to better protect muscle in people as they age.
Orlando, FloridaAges 60–80 - NCT03810768Recruiting
Metabolomics study of ICU-acquired weakness after surgery
This study looks at blood and body chemistry (called metabolomics) to understand and possibly predict muscle weakness that can happen in the ICU after surgery. It may help researchers find better ways to prevent or monitor this problem.
Vienna, State of ViennaAges 18 years+ - NCT05211986RecruitingPhase 1/Phase 2
Test injection safety for knee osteoarthritis muscle weakness
This Phase 1/2 trial studies whether an injection called IMM01-STEM is safe and well-tolerated for people with knee osteoarthritis who also have muscle weakness. It also looks at whether the treatment could help in this group, while carefully monitoring side effects.
Irvine, CaliforniaAges 50–75 - NCT05537298Recruiting
Help for muscle recovery after serious ICU illness
This trial looks at how to improve muscle strength and function after a stay in the ICU for sepsis or acute respiratory failure. If you recover from the illness but your muscles become weak, this study may test an approach to help rebuild strength faster.
Birmingham, AlabamaAges 18 years+ - NCT06321965Recruiting
Study of SMA in Children on SMN-Boosting Therapies
This study is looking for children and teens with spinal muscular atrophy (SMA) who are already on a treatment like Spinraza, Evrysdi, or Zolgensma. The goal is to understand different forms of SMA and how the treatment affects them over time.
Bron, RhoneAges birth–16 years - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT07357662Recruiting
Exercise video games for foot strength and balance in older adults
This study tests how playing fun exercise video games (exergames) can improve foot muscle activity, balance, and ability to move around in older adults who are otherwise healthy.
Tarsus, Mersi̇nAges 65–80 - NCT06819475Recruiting
Muscle health study for childhood leukemia survivors
This study uses imaging to look at how well the mitochondria (the tiny power plants inside your muscle cells) are working. It compares survivors of childhood leukemia who have low muscle mass to healthy volunteers, to understand muscle health and find ways to help.
Memphis, TennesseeAges 18 years+
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Common questions
- Are there clinical trials for muscle atrophy or weakness?
- Yes. Clin2 currently lists 166 recruiting muscle atrophy or weakness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a muscle atrophy or weakness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a muscle atrophy or weakness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.