Clinical trials
Neuromodulation clinical trials
Below are recruiting neuromodulation clinical trials, each written for real people, not researchers. We’re tracking 192 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05834829Enrolling by invitation
Ultrasound scan to study the body’s automatic (stress) responses
This trial tests a low-intensity ultrasound approach while measuring how your nervous system and body respond automatically (like changes in heart rate or stress signals). It may help researchers learn how to stimulate or monitor these responses safely, using imaging and standard monitoring.
Roanoke, VirginiaAges 18–65 - NCT05830942Recruiting
Training walks plus brain stimulation for thinking skills in older adults
This study tests whether a structured walking exercise, combined with brain stimulation and brain scans, can improve or slow decline in thinking skills. It’s aimed at older adults who notice memory or confusion getting worse.
Gainesville, FloridaAges 65 years+ - NCT05839535RecruitingPhase 2
Baduanjin plus brain stimulation for knee osteoarthritis pain
This Phase 2 study tests whether combining Baduanjin (a guided mind-body movement) with neuromodulation can improve knee osteoarthritis symptoms and function. It compares education-based stretching/control and uses MRI scanning as part of the research.
Charlestown, MassachusettsAges 45–75 - NCT05810428Enrolling by invitation
Using AI to predict outcomes and test pain treatment for trigeminal neuralgia
This study uses computer-based (AI) predictions to better understand what happens after a specific procedure for trigeminal neuralgia, a face pain condition. It also checks how well a “pain neuromodulation” approach works and what it feels like over time.
MilanAges 18 years+ - NCT05762796Recruiting
Brain scan and stimulation study for kids with mild concussion
This study tests whether a brain “stimulation” approach, paired with brain imaging (MRI), can help children who still have symptoms after a mild concussion. There is also a comparison group of children without concussion history.
Buffalo, New YorkAges 10–15 - NCT05719454Recruiting
Pacemaker-based nerve therapy for high blood pressure
This study tests a new pacemaker programming method (nerve therapy) to help lower blood pressure. It may be an option if you need a dual-chamber pacemaker and your blood pressure stays high despite medicine.
PragueAges 18 years+ - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT05487131Recruiting
Brain stimulation study for fatigue in healthy adults
This study tests a form of brain/nerve stimulation to see how it affects fatigue. It is looking for healthy adults, which helps researchers understand the effects without other illnesses.
Norman, OklahomaAges 18–50 - NCT05460468Recruiting
Brain stimulation study to improve memory in aging
This study tests a brain-stimulation approach to help improve memory as people age. You may be able to take part if you can consent and meet safety and medical criteria, especially related to brain/nerve health and seizure risk.
Durham, North CarolinaAges 18–75 - NCT05368987Recruiting
TMS for PTSD fear learning and safety memory
This study tests a brain-stimulation treatment called TMS to see if it improves how people with PTSD unlearn fear and form safer memories. It may help reduce fear responses by targeting specific fear-circuit areas in the brain.
Houston, TexasAges 18–70 - NCT05303415Recruiting
Low-intensity ultrasound study during brain MRI
This study tests how low-power focused ultrasound changes brain signals measured during MRI. You may help researchers understand how ultrasound can affect brain activity, even if you don’t have a known brain condition.
Roanoke, VirginiaAges 18–65 - NCT05200923Recruiting
Testing a pelvic nerve device study for bladder and bowel leaks
This study checks how well an implanted pelvic nerve system works for people with bladder overactivity, non-obstructive urinary retention, or fecal incontinence. You may need to keep your current medications steady and track symptoms closely with diaries before and during evaluation.
Indianapolis, IndianaAges 18 years+ - NCT05236010Recruiting
Brain stimulation plus cognitive training for mild TBI memory and thinking
This trial studies whether brain stimulation through the scalp can improve cognitive (thinking and memory) training in people with chronic mild traumatic brain injury (TBI). Participants train on thinking tasks while receiving a targeted “control network neuromodulation” approach to see if it enhances training results.
Minneapolis, MinnesotaAges 18–59 - NCT05141487Recruiting
Testing a nerve stimulation trigger for bladder control
This study tests whether a “triggered” nerve stimulation therapy can help people with nerve-related bladder problems hold urine better and empty their bladder more comfortably. It mainly looks at whether the approach is safe and workable for patients.
Cleveland, OhioAges 18 years+ - NCT05095740Recruiting
Testing brain stimulation for laryngeal dystonia symptoms
This study tests whether a noninvasive brain stimulation treatment (referred to as neuromodulation, such as rTMS) can improve symptoms of laryngeal dystonia. It’s meant to see if stimulating certain brain areas can reduce how severely your voice/throat problem affects you.
Boston, MassachusettsAges 21–85 - NCT04855630Recruiting
Sleep and exercise study for memory changes
This study tests whether improving sleep and increasing exercise can help people with mild memory changes. You'll wear a Fitbit and a sleep headband and use a stationary bike.
Miami, FloridaAges 55–80 - NCT04527445Recruiting
Test to use less X-ray during sacral nerve lead placement
This trial studies whether doctors can place a sacral neuromodulation lead using fewer X-rays. If you’re getting this procedure for overactive bladder, it may help reduce radiation exposure while still guiding correct lead placement.
Loma Linda, CaliforniaAges 18–89 - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT04077346Enrolling by invitation
Testing a brain-to-spine stimulation to help children step
This trial uses a noninvasive neuromodulation approach to stimulate the spinal walking circuits in children after spinal cord injury. It is meant to see whether the treatment can help a child practice stepping when they currently cannot stand or start walking.
Louisville, KentuckyAges 4–12 - NCT03992378Recruiting
Nerve stimulation to calm inflammation in sepsis
This trial tests a form of nerve stimulation to help control the body’s overactive inflammation and “autonomic” nervous system imbalance during sepsis. It may help stabilize blood pressure and reduce complications, depending on the cause of your symptoms.
Oklahoma City, OklahomaAges 18 years+ - NCT03819608Recruiting
Brain stimulation and rehab after mild concussion with PTSD or cognitive issues
This trial studies whether brain stimulation plus targeted brain rehabilitation can improve symptoms after a mild concussion (mTBI). You may be invited if your concussion happened at least 3 months ago and your symptoms are affecting thinking or mood, with or without PTSD.
Chicago, IllinoisAges 18–80 - NCT03876288Recruiting
Study tracks symptoms and nutrition in hard-to-treat gastroparesis
This study follows people with drug-refractory gastroparesis (stomach paralysis symptoms that don’t improve with usual medicines) to better understand how symptoms and nutrition change over time. Your information may help researchers understand patterns that could improve care.
Louisville, KentuckyAges Any age - NCT02916810Recruiting
TMS for persistent auditory hallucinations using a new setup
This study tests a specific brain stimulation approach (TMS) to help reduce auditory hallucinations in adults with schizophrenia who have not improved enough with medications. It may help by changing how the brain regions involved in hearing voices are stimulated.
Houston, TexasAges 18–50 - NCT02898181Recruiting
Ear stimulation for heart failure in hospital
This study tests a gentle electrical stimulation on the ear to see if it can help people with heart failure feel better while they are in the hospital. It might help reduce symptoms and improve heart function.
Oklahoma City, OklahomaAges 18–80
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Common questions
- Are there clinical trials for neuromodulation?
- Yes. Clin2 currently lists 192 recruiting neuromodulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neuromodulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neuromodulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.