Clinical trials
Nitric Oxide clinical trials
Below are recruiting nitric oxide clinical trials, each written for real people, not researchers. We’re tracking 38 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05351502RecruitingPhase 1
Nitric oxide injection for solid tumors that can’t be removed
This Phase 1 study tests whether injecting nitric oxide into certain solid tumors is safe and may help shrink tumors that cannot be removed with surgery. It includes adults with measurable, treatment-resistant skin or under-skin (cutaneous or subcutaneous) tumors and checks for side effects and early signs of benefit.
BeershebaAges 18 years+ - NCT06832163Recruiting
Smart weaning from inhaled nitric oxide for newborns with PPHN
This trial tests a new, smart way to slowly reduce (wean) the inhaled nitric oxide gas that helps babies with a serious lung condition called PPHN. If your baby is already responding well to iNO and needs it for at least 24 hours, this study might help make the weaning process safer and more effective.
ShanghaiAges Any age - NCT05213676RecruitingPhase 4
Testing stopping inhaled nitric oxide in newborns with CDH
This trial studies whether stopping inhaled nitric oxide (a breathing medicine) can be safely used in newborns with congenital diaphragmatic hernia (CDH). It may help the team decide the best way to use this medicine during early newborn care.
Birmingham, AlabamaAges birth–1 month - NCT06702553RecruitingPhase 3
Nitric oxide to reduce support after heart surgery
This trial tests whether giving nitric oxide gas during heart surgery can help patients recover faster and need less breathing and circulation support afterward. It is for people having planned heart or aortic surgery with a heart-lung machine for the first time.
Boston, MassachusettsAges 18 years+ - NCT07172425Recruiting
Testing nitrate-enriched foods for blood vessel health
This study tests whether adding nitrate (a natural compound found in leafy greens and beets) to foods can boost the body’s levels of nitric oxide, which helps blood vessels relax and improve blood flow. If you’re a healthy adult, you may be able to join to help researchers learn how diet affects your blood vessels.
LondonAges 18–60 - NCT05801224Recruiting
Vascular ARDS recruitment after inhaled nitric oxide
This study tests whether giving nitric oxide gas through a breathing tube helps people with a lung condition called ARDS (acute respiratory distress syndrome) recover and leave the intensive care unit sooner. It may help some patients with mild-to-moderate cases who need a ventilator and a central line.
Boston, MassachusettsAges 18–80 - NCT05703191Recruiting
Tests an inhaled nitric oxide system for newborn lung pressure
This study looks at whether an inhaled nitric oxide generator and delivery system can help newborns with high lung blood pressure (pulmonary hypertension). It may help improve oxygen levels during breathing support, but it requires specific medical eligibility and informed consent.
Guangzhou, GuangzhouAges Any age - NCT06657976RecruitingPhase 2
Beetroot juice and exercise for PAD
This study tests whether beetroot juice, which contains natural nitrates that help blood vessels relax, combined with exercise, can improve walking ability in people with peripheral artery disease (PAD). You might be able to join if you have PAD, can walk without a walker, and are willing to avoid beet products for a while.
Chicago, IllinoisAges 50 years+ - NCT06852924Recruiting
Inhaled nitric oxide for HAPE treatment trial
This trial tests if inhaled nitric oxide helps people with high-altitude pulmonary edema (fluid in the lungs from high altitude). It may offer a new treatment option for those with mild to moderate symptoms.
Lhasa, TibetAges 18–65 - NCT05616910Enrolling by invitationPhase 2
Inhaled nitric oxide for microvascular problems after brain injury
This Phase 2 study tests whether inhaled nitric oxide can improve tiny blood-flow problems in the brain after traumatic brain injury. If you qualify, you may receive inhaled nitric oxide and be monitored for safety and recovery.
Philadelphia, PennsylvaniaAges 18–75 - NCT07382258Recruiting
Inhaled nitric oxide for COPD: a clinical study
This trial tests whether a gas called nitric oxide, breathed in through the nose or mouth, can help people with moderate to severe COPD. It could improve breathing and quality of life.
Nanjing, JiangsuAges 40–75 - NCT06741137Recruiting
Inhaled nitric oxide and prone positioning for ARDS
This trial is testing whether adding inhaled nitric oxide to lying on your stomach (prone position) can help people with severe lung failure (ARDS) who are on a ventilator. It uses a special monitor (EIT) to check lung function in real time.
Yangzhou, JiangsuAges 18–80 - NCT05896800Recruiting
Inhaled nitric oxide for moderate to severe COPD symptoms
This study tests whether inhaled nitric oxide gas can improve outcomes in people with moderate-to-severe chronic obstructive pulmonary disease (COPD). It may help reduce breathing problems by targeting how airways and blood vessels respond in the lungs.
Nanjing, JiangsuAges 40–75 - NCT07099144Recruiting
Inhaled nitric oxide for newborns with breathing failure and high blood pressure in the lungs
This trial tests whether inhaled nitric oxide gas can help full-term newborns who have severe breathing problems and high blood pressure in their lungs. It aims to improve oxygen levels and reduce the need for more intensive support.
Guangzhou, GuangdongAges Up to 1 week - NCT05101746Enrolling by invitationPhase 2/Phase 3
Nitric oxide to protect brain and kidneys in babies during heart surgery
This trial studies whether giving nitric oxide during heart-lung bypass surgery can help protect a baby’s brain and kidneys. If you qualify, the study team will check outcomes after surgery to see if benefits happen compared with usual care.
Nashville, TennesseeAges birth–1 year - NCT06672952Recruiting
Citrus compound for exercise, blood flow, and stress in overweight adults
This study looks at whether a natural citrus compound called glucosyl-hesperidin (CitraPeak) can boost your exercise performance, improve blood flow, reduce stress, and sharpen thinking. Researchers want to see if it works differently for people who are moderately overweight or mildly obese.
Saint Charles, MissouriAges 18–50 - NCT07566611Recruiting
Ciliary Function in Adults with Bronchiectasis
This study looks for signs of ciliary dyskinesia (a condition affecting tiny hair-like structures in the lungs) in adults who have bronchiectasis (damaged airways). Understanding this connection may help doctors better treat and manage your lung disease.
Indianapolis, IndianaAges 18 years+ - NCT04216927RecruitingPhase 3
Neonates on heart-lung bypass get NO to prevent kidney injury
This Phase 3 study tests whether not giving nitric oxide during heart-lung bypass in newborns helps reduce the risk of acute kidney injury. It focuses on newborns having heart surgery for congenital heart disease.
Cincinnati, OhioAges 1 day–1 month - NCT04738422Enrolling by invitationPhase 2
Measuring airway acidity using exhaled air breath tests
This trial studies how “airway pH” (how acidic your breathing tubes are) changes after you drink or inhale an alkaline buffer, using special breath measurements. It may help researchers better understand and measure airway inflammation in people with lung conditions or in healthy non-smokers.
Indianapolis, IndianaAges 18–60 - NCT06201611RecruitingPhase 2/Phase 3
Nebivolol for diabetic nerve damage study
This study tests whether the drug nebivolol (a type of beta-blocker) can help slow or reverse nerve damage caused by diabetes. It is for people with recent diabetes and confirmed neuropathy.
Bangalore, KarnatakaAges Up to 18 years - NCT06159608RecruitingEarly Phase 1
E-cigarette effects on blood vessels in young adults
This study looks at how e-cigarettes affect blood vessels in young adults. Researchers want to compare first-time vapers, experienced vapers, and non-vapers to see if there are differences between men and women.
Iowa City, IowaAges 18–24 - NCT06680895Recruiting
FeNO study in ICU patients with breathing support
This study measures a lung inflammation marker called FeNO in ICU patients on a breathing machine. It may help doctors understand lung health and guide treatment.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07729943Recruiting
Ginseng & Cordyceps for Better Exercise Performance
This trial tests whether a combination of ginseng and cordyceps (a type of mushroom) can help improve how well your body uses oxygen during exercise. It's for healthy, active adults aged 40 to 65 who want to see if these natural ingredients can boost stamina and recovery.
Canfield, OhioAges 40–65 - NCT05287022Recruiting
Nasal nitric oxide test to improve primary ciliary dyskinesia care
This study tests whether a breathing test called nasal nitric oxide can help improve care for people with primary ciliary dyskinesia (PCD) or related lung/sinus problems. The goal is to see if the test can better guide diagnosis and treatment planning.
Little Rock, ArkansasAges 2–99
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Common questions
- Are there clinical trials for nitric oxide?
- Yes. Clin2 currently lists 38 recruiting nitric oxide studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nitric oxide trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nitric oxide trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.