Clinical trials
Non-invasive Ventilation clinical trials
Below are recruiting non-invasive ventilation clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05027035Recruiting
Compare diaphragm surgery versus breathing machine support
This trial is studying whether surgery, instead of using a breathing machine, works better for people with one-sided diaphragm paralysis. It aims to improve breathing comfort and function in the right patients.
GroningenAges 18 years+ - NCT05136222Recruiting
Testing a night breathing machine setting for muscle-nerve disease
This study helps find the best night-time settings for a non-invasive breathing support device (a machine that helps breathing without a tube). It may help people with motor neurone disease start long-term breathing support more comfortably and effectively.
AdelaideAges 18 years+ - NCT05163639RecruitingEarly Phase 1
Noninvasive brain and spinal training for spinal cord injury
This early study tests a noninvasive way of training the nervous system to see how it affects “associative plasticity,” or the brain/spinal cord’s ability to change with practice. It may help researchers learn strategies that could improve function for people with spinal cord injury.
New York, New YorkAges 18–80 - NCT05686850Recruiting
Noninvasive breathing support vs high-flow oxygen after ICU extubation
This study compares two breathing supports used after a breathing tube is removed in the ICU: a noninvasive ventilator (mask-based) versus high-flow nasal oxygen. It aims to see which one works better when patients develop breathing trouble soon after extubation.
BrusselsAges 18 years+ - NCT05785637Recruiting
Home sleep testing after starting noninvasive breathing support
This study checks breathing/sleep measurements done at home for people who recently started a machine that helps them breathe without an endotracheal tube. It may help the team confirm how well home monitoring works after hospital setup of this breathing support.
GarchesAges 18 years+ - NCT06021938Recruiting
Virtual Reality for Breathlessness in ALS
This trial tests if using immersive virtual reality can help reduce ongoing shortness of breath in people with ALS who already use a breathing mask (non-invasive ventilation). It may offer a drug-free way to feel more comfortable.
Paris, FranceAges 18 years+ - NCT06030349Recruiting
Breathing support for kids with Down syndrome and sleep apnea
This trial looks at how well non-invasive breathing machines help children with Down syndrome who have obstructive sleep apnea. It tracks their health and sleep over time to see if the treatment works and improves daily life.
DublinAges 6 months–16 years - NCT06053684Recruiting
Comparing two breathing machines for babies with bronchiolitis
This study tests if a new type of breathing machine (NAVA) works better than the standard machine for babies under 2 with severe bronchiolitis in the pediatric ICU. The goal is to see which machine helps babies breathe easier and avoid needing a breathing tube.
The Bronx, New YorkAges birth–2 years - NCT06114667Recruiting
Nasal high flow vs. mask for COPD flare-up
This study compares two types of breathing support for people having a severe COPD flare-up with high carbon dioxide and acidic blood. It tests if a gentle air flow through the nose (nasal high flow) works as well as a mask (non-invasive ventilation) to help you breathe better.
Montpellier, MontepllierAges 18–85 - NCT06339580RecruitingPhase 2
Volume-targeted ventilation for neuromuscular disease
This trial tests a smarter ventilator setting that automatically adjusts pressure to deliver a steady amount of air. It may help people with slowly worsening muscle weakness who already use a nighttime breathing machine.
London, LondonAges 18–80 - NCT06795971Recruiting
Comparing oxygen methods for hypoxemic respiratory failure
This trial compares three ways of giving extra oxygen to people with low blood oxygen levels: a face mask with continuous pressure, a noninvasive ventilator, or high-flow oxygen through the nose. The goal is to see which method helps people avoid needing a breathing tube.
Nanjing, JiangsuAges 18 years+ - NCT06844370Recruiting
Home vs hospital NIV care for MND
This study compares two ways of starting non-invasive ventilation (NIV) — a breathing machine — for people with motor neurone disease (MND). It aims to see if starting NIV at home is as safe and effective as starting it in the hospital.
CambridgeAges 18 years+ - NCT06966752Recruiting
Comparing two breathing supports for preterm babies with breathing problems
This study compares two types of breathing support (CPAP and NIPPV) for preterm babies with breathing problems. It aims to find which method works better for helping babies breathe easier.
Vilnius, Vilnius CountyAges birth–10 months - NCT06996509Recruiting
Noninvasive breathing support for Guillain-Barré syndrome
This trial tests whether noninvasive breathing support (like a mask or nasal prongs) can help people with Guillain-Barré syndrome who have trouble breathing. It aims to see if this approach can avoid the need for a breathing tube.
Asyut, AssuitAges 18 years+ - NCT06996834Recruiting
Comparing breathing support methods for pneumonia-related breathing failure
This trial tests two noninvasive breathing support methods (NIV and HVNI) for people with pneumonia who are having trouble breathing. The goal is to see which method works better to help you avoid needing a breathing tube.
Asyut, AssuitAges 18 years+ - NCT07047092RecruitingPhase 3
CPAP vs. NIV for sleep apnea in COPD after breathing failure
This trial compares two breathing devices (CPAP and NIV) for people with both COPD and sleep apnea who recently needed breathing help in the hospital. The goal is to see which device works better at preventing future breathing emergencies.
ParisAges 18–84 - NCT07059689Recruiting
Comparing breathing support after heart surgery in children
This trial compares two types of breathing support (high-flow nasal cannula vs. non-invasive ventilation) in children who have recently had heart surgery and are at high risk of having trouble breathing after their breathing tube is removed. The goal is to see which method works better to help them breathe on their own.
Jakarta, DKI JakartaAges Up to 18 years - NCT07071935RecruitingPhase 2
Early ventilation study for newly diagnosed ALS
This trial tests whether starting non-invasive ventilation (breathing support) early in ALS helps people breathe easier and live better. If you've been diagnosed with ALS in the last 6 months and haven't used a breathing machine before, you may qualify.
Hershey, PennsylvaniaAges 18 years+ - NCT07267104Recruiting
Home ventilation study for COPD patients
This study looks at signals from non-invasive home ventilators to better track COPD. It may help understand how to manage the condition using data from your device.
Sabadell, BarcelonaAges 40–80 - NCT02464696Recruiting
Noninvasive breathing support to avoid tube breathing in cancer
This trial studies a mask-based breathing treatment (noninvasive ventilation) for people with cancer and serious breathing trouble, to see if it can prevent the need for intubation (putting a breathing tube in). If you qualify, the goal is to help you breathe better without invasive airway support when possible.
Houston, TexasAges 18 years+ - NCT07414108Recruiting
Predicting response to breathing support in COPD
This study looks at whether nighttime breathing problems can predict long-term success with a non-invasive breathing machine in people with COPD who have high carbon dioxide levels in their blood. The goal is to help doctors decide who will benefit most from this therapy.
BolognaAges 18 years+ - NCT07536750Recruiting
Comparing Two Sedation Drugs for ICU Patients on Breathing Support
This study compares two medications (ciprofol and propofol) used to keep ICU patients calm and comfortable while they receive non-invasive breathing support, such as oxygen masks or tubes that help them breathe without a breathing tube in their windpipe. Researchers want to see which drug works better and is safer.
Guangzhou, GuangdongAges 18 years+ - NCT07235345Enrolling by invitation
Lung medication with different oxygen levels for premature babies
This study tests a lung medication called pulmonary surfactant, given with different oxygen levels, to help very premature babies (born before 32 weeks) who have breathing difficulties. The goal is to see which oxygen level works best with non-invasive breathing support.
Henan, ZhengzhouAges 6 months–7 months - NCT07211906Enrolling by invitation
Oral care education for home ventilator users
This study tests whether a simple oral care education program, delivered through the LINE app, can improve mouth health and quality of life for people who use a non-invasive breathing machine at home.
Chiayi City, TaiwanAges 18 years+
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Common questions
- Are there clinical trials for non-invasive ventilation?
- Yes. Clin2 currently lists 62 recruiting non-invasive ventilation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a non-invasive ventilation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a non-invasive ventilation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Non Muscle Invasive Bladder Cancer
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Invasive Mechanical Ventilation
- Non-Muscle Invasive Bladder Urothelial Carcinoma
- Non-Muscle Invasive Bladder Neoplasms
- High Risk Non-muscle Invasive Bladder Cancer
- Metastatic Non-squamous Non Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.