Clinical trials
Oral Cancer clinical trials
Below are recruiting oral cancer clinical trials, each written for real people, not researchers. We’re tracking 279 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06315881RecruitingPhase 2
Study of Nicotine Pouches for Cigarette or Snuff Users
This trial tests nicotine pouches (like small pouches you put in your mouth) as a way to help people who smoke cigarettes or use moist snuff. It studies how your body reacts to these pouches under controlled conditions and during daily life.
Columbus, OhioAges 21 years+ - NCT04870762RecruitingTeam says not enrollingPhase 2
3D-printed tongue stents during head and neck radiation
This Phase 2 study tests whether customized 3D-printed stents can be used safely during head and neck radiotherapy. If you’re having radiation (with or without chemotherapy), the stent may help make treatment easier and more precise, potentially improving the experience and outcomes.
Phoenix, ArizonaAges 18 years+ - NCT06763536Recruiting
Comparing nicotine pouches vs. nicotine patches or gum to help smokers in rural Appalachia quit
This study tests if oral nicotine pouches work better than nicotine patches or gum to help you smoke less. You’ll use one of these products for a while and check in with the study team. This is for adults who live in rural Appalachian counties and smoke at least 5 cigarettes a day.
Columbus, OhioAges 21 years+ - NCT03997643RecruitingPhase 2
Radiation plan trial to help protect swallowing after mouth cancer
This Phase 2 study tests whether changing the “radiation volume” (how much area is treated) can better preserve swallowing after surgery for oral cavity squamous cell cancer. It may help reduce swallowing problems while still treating the cancer safely.
Miami, FloridaAges 18 years+ - NCT06190847Recruiting
Oral bacteria and response to chemoradiotherapy in esophageal cancer
This study looks at how the bacteria in your mouth might affect how well chemoradiotherapy (a combination of chemotherapy and radiation) works for esophageal cancer that cannot be removed by surgery. The goal is to see if the oral microbiome can predict treatment response.
Hefei, AnhuiAges 18–85 - NCT07676461Recruiting
Microbiome study in advanced cancer patients starting immunotherapy
This study looks at the bacteria in your mouth, gut, and tumors to see if they affect how well first-line immunotherapy works. It is for people with advanced stomach, colorectal, breast, cervical, or head-and-neck cancer.
Bogotá, Bogota D.C.Ages 18 years+ - NCT06545942RecruitingPhase 1
Studying MOMA-313 for advanced or metastatic solid tumors
This trial tests a new oral drug, MOMA-313, alone or with another drug (olaparib), in people whose cancer has a specific DNA repair problem (HR-deficient mutation). It aims to see if the drug can shrink tumors or slow their growth.
Goodyear, ArizonaAges 18 years+ - NCT07570979RecruitingPhase 1
Testing INR731 for Metastatic Prostate Cancer
This trial tests a new drug called INR731, given by mouth, for men with prostate cancer that has spread to other parts of the body. The study will check if the drug is safe and how well it works, either alone or combined with other prostate cancer medicines.
Dallas, TexasAges 18 years+ - NCT07207395RecruitingPhase 2
Study of JBI-802 with or without pembrolizumab for STK11-mutated lung cancer
This trial tests a new oral drug, JBI-802, alone or with pembrolizumab, for people with advanced non-small cell lung cancer that has a specific change in the STK11 gene. The goal is to see if this treatment can help shrink tumors or slow their growth.
Cincinnati, OhioAges 18 years+ - NCT06764680RecruitingPhase 2
Oral drugs and radiation for advanced colorectal cancer after standard therapy
This trial tests a combination of oral chemotherapy, targeted therapy, and immunotherapy, with or without radiation, for people with advanced colorectal cancer that hasn't responded to at least two prior treatments. The goal is to see if this approach can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18 years+ - NCT06974110RecruitingPhase 1
Study of a new drug for advanced solid tumors with MSI-H or dMMR
This trial tests an oral medication called MOMA-341 in people with advanced solid tumors that have high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR). It aims to see if the drug can help when prior immunotherapy hasn't worked or isn't available.
Phoenix, ArizonaAges 18 years+ - NCT07346092Recruiting
Health beliefs and social behaviors about nicotine pouches
This study looks at how graduate students at Ohio State University perceive and use oral nicotine pouches. The goal is to create better ways to communicate the addictive risks of these products.
Columbus, OhioAges 21 years+ - NCT07578064RecruitingPhase 4
Comparing two treatments for low white blood cells during breast cancer therapy
This study compares two medications—Shengbai Oral Liquid and Leucogen Tablets—to help raise white blood cell counts in breast cancer patients whose counts drop during cancer treatment. Both drugs aim to help your body recover faster and allow you to continue your cancer therapy on schedule.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05417308RecruitingEarly Phase 1
Minoxidil for hair loss from breast cancer hormone therapy
This early-phase study tests whether using minoxidil as a lotion (topical) or by mouth (oral) can improve hair loss caused by breast cancer hormone (endocrine) therapy. It may help you keep or regrow hair while continuing your cancer treatment.
Columbus, OhioAges 18 years+ - NCT06191978RecruitingPhase 1
Testing venetoclax with decitabine/cedazuridine for pediatric AML
This trial tests a combination of two oral drugs (venetoclax and decitabine/cedazuridine) for children and teens whose acute myeloid leukemia (AML) has returned or not improved after prior treatment. The goal is to find a safe dose and see if the drugs can help shrink or control the leukemia.
Houston, TexasAges 2–18 - NCT06736379RecruitingPhase 1
RNA Therapy Injections for Head and Neck Cancer
This trial tests a new type of immunotherapy made of self-amplifying RNA (saRNA) that produces a protein called IL-12. It's injected directly into head and neck tumors to help your immune system fight the cancer. The study is for people whose cancer has not responded well to standard treatments or who are having surgery to remove their tumor.
Stanford, CaliforniaAges 18 years+ - NCT06813365RecruitingPhase 1
DZD6008 for advanced NSCLC with EGFR mutations
This trial tests an experimental oral drug called DZD6008 for people with advanced non-small cell lung cancer (NSCLC) that has certain EGFR mutations. It aims to see if the drug can help those whose cancer has stopped responding to other treatments, or who haven't had treatment yet.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06905197RecruitingPhase 1
Study of DZD6008 for advanced NSCLC with EGFR mutations
This trial tests an oral drug called DZD6008 for people with advanced non-small cell lung cancer (NSCLC) that has certain EGFR mutations. It may be an option for those who have tried other EGFR treatments or are new to treatment.
New York, New YorkAges 18 years+ - NCT07664683Recruiting
How changing your cancer pill's appearance affects your treatment
This study looks at how switching from a brand-name cancer pill to a generic version (or between two generics) affects your daily routine, ability to stay on treatment, and overall well-being. If you've been on one of these specific pills for at least 6 months and recently made a switch, the researchers want to learn from your experience.
San Juan, AlicanteAges 18 years+ - NCT05592886Recruiting
Oral probiotic-and-prebiotic drink to prevent colon polyps returning
This study tests whether an oral synbiotic (a probiotic plus a prebiotic) can reduce the chance that advanced colon growths come back after they were removed. It also looks at changes in stool-related bacterial “gene markers” that may signal lower risk over time.
Hohhot, Inner MongoliaAges 18–90 - NCT04265430RecruitingPhase 4
MRI scans to predict normal-tissue side effects after treatment
This trial uses repeated MRI scans to better predict which patients may develop painful jaw and mouth tissue problems after radiation and/or certain bone or blood-vessel medicines. It may help clinicians spot problems earlier and tailor follow-up care.
Houston, TexasAges 18 years+ - NCT04754321RecruitingPhase 1
Test immunotherapy with salvage surgery and IORT for head and neck cancer
This Phase 1 trial tests a new plan that combines immunotherapy with surgery, plus a targeted radiation treatment called IORT. It is for people whose head and neck squamous cell cancer has come back or never fully went away and can be operated on. The goal is to shrink or control the cancer and see how safe the approach is.
Columbus, OhioAges 18 years+ - NCT06982274RecruitingPhase 2
Arsenic and ATRA for new APL patients
This trial tests a combination of oral arsenic and ATRA for people newly diagnosed with acute promyelocytic leukemia (APL). It aims to see if this drug combo can treat the disease effectively without standard chemotherapy.
São Paulo, São PauloAges 18–75 - NCT06992882RecruitingPhase 3
Comparing two chemo regimens with Herceptin for early breast cancer
This trial tests if taking oral chemotherapy pills with trastuzumab (Herceptin) works as well as IV chemo (paclitaxel) with Herceptin after surgery for HER2-positive, lymph node-negative early breast cancer. It aims to find a more convenient treatment option.
Shanghai, Shanghai MunicipalityAges 18–70
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Common questions
- Are there clinical trials for oral cancer?
- Yes. Clin2 currently lists 279 recruiting oral cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.