Clinical trials
Oral Cavity Squamous Cell Carcinoma clinical trials
Below are recruiting oral cavity squamous cell carcinoma clinical trials, each written for real people, not researchers. We’re tracking 173 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05098119RecruitingPhase 2
Study drugs before surgery for mouth or throat cancer
This Phase 2 trial tests giving the immunotherapy drug sintilimab before surgery, along with fewer chemotherapy cycles. The goal is to shrink or control oral or throat squamous cell cancers while keeping side effects lower, before the tumor is removed.
Guangzhou, GuangdongAges 18–80 - NCT05104619Recruiting
Analyzing Tongue Cancer Tissue During Surgery
This study examines tongue cancer tissue samples removed during surgery using special imaging techniques. Researchers hope this analysis helps improve how doctors understand and treat tongue cancer in the future.
Amiens, PicardieAges 18 years+ - NCT05144698RecruitingPhase 1/Phase 2
RAPA-201 cell therapy for certain advanced lung and head cancers
This Phase 1/2 trial tests RAPA-201, a personalized immune cell treatment made from your own T cells, for advanced solid tumors. It may help people whose cancer has come back after standard treatment and after an anti–PD-1/PD-L1 antibody.
Hackensack, New JerseyAges 18 years+ - NCT05176483RecruitingPhase 1
Zanzalintinib with immunotherapy for advanced solid tumors
This Phase 1 study tests zanzalintinib (a targeted medicine) combined with immunotherapy medicines in people with advanced solid cancers that can’t be removed by surgery. It aims to see if the combination can control the cancer and determine the safest dose.
Phoenix, ArizonaAges 18 years+ - NCT05283226RecruitingPhase 2
Oral anti-cancer pill plus paclitaxel after immunotherapy failure
This Phase 2 trial studies an oral study drug (NRC-2694-A) given with paclitaxel to treat head and neck squamous cell cancer that has come back or spread after immunotherapy. It tests whether this combination is safer and works better than expected for people whose cancer progressed on immune checkpoint inhibitors.
Fullerton, CaliforniaAges 18 years+ - NCT05286619RecruitingPhase 2
Pembrolizumab with chemotherapy for recurrent head and neck cancer
This trial studies whether pembrolizumab plus chemotherapy (platinum and gemcitabine) can control recurrent or metastatic head and neck squamous cell carcinoma that can’t be cured with local treatments. It may help shrink tumors and slow disease growth in people who haven’t had cancer medicines for this stage before.
Kuala LumpurAges 18 years+ - NCT05668858RecruitingPhase 1/Phase 2
Test antibodies plus or minus chemo for advanced head and neck cancer
This early-phase study tests a combination of antibody medicines (with optional chemotherapy) in people with advanced or metastatic head and neck squamous cell carcinoma. The goal is to see how well the treatment controls the cancer and what side effects are like.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05674396RecruitingPhase 2
Short-course radiation to ease symptoms from head and neck cancer
This Phase 2 trial tests a specific, shorter type of focused radiation to help relieve symptoms from head and neck squamous cell carcinoma. It compares two radiation timing/planning approaches to see which better improves comfort and quality of life.
Houston, TexasAges 18 years+ - NCT05707078Recruiting
PET/CT follow-up for head and neck cancer
This study uses a PET/CT scan (a special scan that can look for signs of cancer activity) after curative treatment for head and neck squamous cell cancer. It aims to help check how well prior treatment is working and whether cancer may come back.
CopenhagenAges 18 years+ - NCT05726370RecruitingPhase 2
Pembrolizumab plus chemo before surgery for recurrent head and neck cancer
This Phase 2 trial tests whether giving pembrolizumab (an immune therapy) plus chemotherapy before curative surgery can improve outcomes for people with resectable, recurrent head and neck squamous cell cancer. It also studies how these treatments affect the tumor and immune response using required tissue and blood samples.
Boston, MassachusettsAges 18 years+ - NCT05774483Recruiting
Check nodes in early mouth cancer using a biopsy or planned neck surgery
This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.
Mumbai, MaharashtraAges 18–80 - NCT05791149Recruiting
Saliva test to help diagnose oral cavity cancer
This study looks for changes in saliva (epigenetic biomarkers) that may help doctors diagnose squamous cell carcinoma in the mouth. You may be asked for saliva samples and usual clinical checks to see whether the test can help with diagnosis, especially before surgery.
Amiens, PicardieAges 18 years+ - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT05865028RecruitingPhase 2
Test drug APG-157 for abnormal mouth tissue
This Phase 2 trial studies whether APG-157 can safely improve abnormal cells in the mouth (dysplasia) or early cancer-like changes (carcinoma in situ). You may be eligible if you have a visible, biopsy-proven lesion and can take oral medication while meeting blood and health requirements.
Miami, FloridaAges 18 years+ - NCT05893888RecruitingPhase 2/Phase 3
Testing three investigational drugs for mouth and lung cancers
This trial tests whether PRV111, PRV211, and PRV131 are safe and work better than expected for certain mouth (lip/oral cavity) cancers and lung cancers. It may help by trying a new approach given directly to the tumor and then monitoring how well it shrinks and how safe it is.
Duarte, CaliforniaAges 18–100 - NCT06016920RecruitingPhase 1/Phase 2
HPV16 vaccine plus Keytruda for oropharyngeal cancer
This trial tests a new vaccine (VB10.16) combined with the immunotherapy Keytruda (pembrolizumab) for people with HPV16-positive oropharyngeal cancer that has spread or come back. The goal is to see if the combination helps shrink tumors or slow cancer growth.
OlomoucAges 18 years+ - NCT06030440RecruitingPhase 2/Phase 3
Lowering radiation after head and neck cancer surgery
This study tests whether giving a lower dose of radiation after surgery for head and neck cancer is as safe and effective as the standard dose. It aims to reduce side effects while still preventing the cancer from coming back.
Erlangen, BavariaAges 18 years+ - NCT06056336RecruitingPhase 2
Perioperative tislelizumab plus chemo for esophageal cancer
This trial tests whether giving tislelizumab (an immunotherapy) along with chemotherapy before and after surgery can help people with a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this combination improves outcomes for patients whose cancer is in the chest and can be removed with surgery.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06061705Recruiting
Finding markers in patients with head and neck cancer on immunotherapy
This trial looks for specific signs in your blood and tumor tissue that may show how well immunotherapy is working for recurrent or metastatic head and neck cancer. It aims to help doctors personalize treatment in the future.
ParisAges 18 years+ - NCT06088381RecruitingPhase 2
HPV-related throat cancer treatment based on tumor DNA levels
This trial tests if monitoring cancer DNA left in your blood after surgery can help decide if you need additional treatment. It is for people with HPV-positive oropharynx (throat) cancer who have a certain amount of cancer DNA detected before surgery.
Baltimore, MarylandAges 18 years+ - NCT06097468RecruitingPhase 1/Phase 2
Nisin for mouth cancer: a treatment trial
This study tests whether a natural substance called nisin, applied to mouth cancer, can help the body fight cancer cells. It is for people with a specific type of mouth cancer who are already scheduled for surgery.
San Francisco, CaliforniaAges 18 years+ - NCT06129864RecruitingPhase 3
Study of Volrustomig for advanced head and neck cancer after chemoradiation
This trial tests a new drug called volrustomig (MEDI5752) for people with advanced head and neck cancer that was not removed by surgery and has been treated with chemoradiation. The goal is to see if the drug can help prevent the cancer from coming back.
Birmingham, AlabamaAges 18–130 - NCT06162377RecruitingPhase 4
Methylnaltrexone before surgery for mouth cancer
This trial tests if taking methylnaltrexone for two weeks before surgery can help people with mouth cancer. It is a small, early study to see how the drug affects the tumor and the body.
Houston, TexasAges 18 years+ - NCT06183268Recruiting
Proton therapy for head and neck cancer skin side effects
This study looks at how proton therapy affects skin in people with head and neck cancer. It aims to better understand and manage skin reactions during treatment.
Knoxville, TennesseeAges 18 years+
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Common questions
- Are there clinical trials for oral cavity squamous cell carcinoma?
- Yes. Clin2 currently lists 173 recruiting oral cavity squamous cell carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral cavity squamous cell carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral cavity squamous cell carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Recurrent Oral Cavity Squamous Cell Carcinoma
- Metastatic Oral Cavity Squamous Cell Carcinoma
- Locally Recurrent Oral Cavity Squamous Cell Carcinoma
- Oral Squamous Cell Carcinoma
- Locally Advanced Oral Squamous Cell Carcinoma
- Head and Neck Squamous Cell Carcinoma
- Esophageal Squamous Cell Carcinoma
- Squamous Cell Carcinoma
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.