Clinical trials
Pain, Nerve clinical trials
Below are recruiting pain, nerve clinical trials, each written for real people, not researchers. We’re tracking 217 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07090668Recruiting
Ear stimulation for pain in sickle cell disease
This trial tests a safe, non-drug device that gently stimulates the ear to help reduce pain in children with sickle cell disease who are in the hospital for a pain crisis. It may offer a new way to manage pain without extra medication.
Atlanta, GeorgiaAges 7–18 - NCT07385677Recruiting
Comparing a new approach to usual care for lateral elbow pain
This trial tests if a new way of thinking about the nerves and layers in your arm (called TINLL) works better than usual therapy for people with pain on the outside of their elbow. It may help you get better faster.
South Burlington, VermontAges 18 years+ - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT03756961Recruiting
Opioid-free care plan for people having weight-loss surgery
This trial studies whether an opioid-free or opioid-sparing care pathway can improve comfort and outcomes for adults undergoing laparoscopic weight-loss surgery. It may help people avoid side effects from opioid pain medicines while still managing pain safely.
Lindesberg, Region ÖrebroAges 18 years+ - NCT03365908Enrolling by invitation
Pain Management After ACL Reconstruction Surgery
This study looks at ways to manage pain in adults who are getting surgery to repair a torn ACL (a knee ligament). It may help improve comfort and recovery after ACL reconstruction.
Sacramento, CaliforniaAges 18–45 - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT06840262Recruiting
Nerve surgery for pain after cancer amputation
This study tests two surgical techniques—target muscle re-innervation and regenerative peripheral nerve interfaces—alone or together, to help reduce pain felt in the remaining limb or the missing limb (phantom pain) after amputation for cancer. The goal is to find the best way to manage pain and improve quality of life.
Houston, TexasAges 18 years+ - NCT06069154Enrolling by invitation
Freezing nerves for rib fracture pain
This study tests a procedure called cryoneurolysis, which uses cold to temporarily freeze nerves near broken ribs to relieve pain. It is for adults who have 1 to 6 recently broken ribs with at least moderate pain and are already getting a nerve block injection.
La Jolla, CaliforniaAges 18 years+ - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT06568770RecruitingPhase 2/Phase 3
Comparing two nerve blocks for femur fracture surgery pain
This trial tests if one type of nerve block (PENG block) works better than another (S-FICB) for controlling pain during and after femur fracture surgery. Both blocks are guided by ultrasound to help with your recovery.
Sahiwal, Punjab ProvinceAges 20–70 - NCT06243718Recruiting
Surgery for paralyzed diaphragm nerve
This trial looks at how patients feel and recover after surgery to fix the nerve that controls the diaphragm. It aims to learn about people's experiences to improve care for diaphragmatic paralysis.
Red Bank, New JerseyAges 18–70 - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT06515691Recruiting
Nerve block for pain after weight loss surgery
This study tests a nerve block (an injection near the nerves) to see if it helps reduce pain after laparoscopic sleeve gastrectomy. The block is called a modified thoracoabdominal nerve plane block, and it may lead to better pain control and recovery.
Istanbul, BagcilarAges 18–65 - NCT05865327Recruiting
Nerve freezing for rib-fracture pain using ultrasound guidance
This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.
Toronto, OntarioAges 18–100 - NCT05672784Recruiting
Knee numbing injections during knee replacement surgery
This trial compares two ways of numbing a knee area during planned knee replacement surgery: a nerve block alone versus a nerve block plus additional numbing medicine near the back of the knee. It may help doctors find which approach improves pain control and recovery while keeping side effects low.
ZagazigAges 21–60 - NCT07614945Recruiting
Reflexology for Pain and Sleep in Fibromyalgia
This study tests whether reflexology—a massage technique applied to specific points on the feet and hands—can help reduce pain and improve sleep in women with fibromyalgia. Fibromyalgia causes widespread muscle pain and sleep problems, and this trial explores whether reflexology might offer relief.
Al Mansurah, Dakahlia GovernorateAges 18–65 - NCT05748015Recruiting
Checking how the nervous system is affected in multiple sclerosis
This study looks at signs of how your automatic “control” nerves (the autonomic nervous system) may be affected in people with multiple sclerosis. It may help researchers better understand different types of MS and how to recognize nervous-system involvement.
Telese Terme, BeneventoAges 18 years+ - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT05602636RecruitingPhase 4
Nerve-block pain options during forearm surgery
This trial compares three ways to control pain during forearm surgery: different nerve blocks versus using a PCA pain pump. It may help find the approach that gives better pain relief and comfort after surgery, especially for longer procedures.
DamiettaAges 18–70 - NCT07721220Recruiting
Nerve gliding moves for strength and endurance in athletes
This study tests whether a gentle nerve-stretching technique (neurodynamics) can improve leg strength and endurance in athletes. If you're 18–30, currently active in sports or intense training, and have no recent leg injury or surgery, you may be able to join.
High Point, North CarolinaAges 18–30 - NCT07709975Recruiting
Pain relief and early movement for older ICU patients
This study tests different ways to manage pain and help older patients get moving again sooner after major surgery. If you are 65 or older and in the ICU, this trial may help you recover more comfortably and quickly.
Istanbul, IstanbulAges 65 years+ - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT06778005Recruiting
Ultrasound of leg nerves in type 2 diabetes with nerve damage
This study uses ultrasound (an imaging test) to measure the nerves in the legs of people with type 2 diabetes who have nerve damage. It helps doctors learn more about how diabetes affects nerves.
Istanbul, ÜsküdarAges 18–65 - NCT07218133Recruiting
Ear Stimulation to Reduce Pain After Spine Surgery
This trial tests whether a gentle electrical stimulation delivered through the ear can reduce inflammation and pain after major spinal fusion surgery. If you are having a long spinal fusion, you might be able to join.
St Louis, MissouriAges 18 years+
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Common questions
- Are there clinical trials for pain, nerve?
- Yes. Clin2 currently lists 217 recruiting pain, nerve studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, nerve trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, nerve trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.