Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05858996RecruitingPhase 2
Testing a pain care guideline for older adults with dementia
This trial tests a clinical guideline to improve how pain is identified and managed. It may help if you or your loved one has dementia and ongoing pain, with a focus on better pain care in nursing homes.
Baltimore, MarylandAges 60 years+ - NCT05814497Recruiting
Brain scan study of how kids process chronic pain
This study looks at how the brain processes pain sensations in children with certain long-lasting pain conditions. It may help researchers understand what’s happening in the nervous system and guide better treatments.
Cincinnati, OhioAges 10–17 - NCT05811624Recruiting
Lifestyle program for weight and chronic low back pain
This trial studies whether a lifestyle change program (often diet and activity habits) can reduce long-lasting low back pain in overweight or obese adults. It also aims to see if people can keep their usual care while adding the lifestyle program.
BrusselsAges 18–65 - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT05315596Enrolling by invitation
Tracking pain and recovery answers after surgery
This study checks how patients report pain and recovery over time after surgery. It may help improve how hospitals understand and manage pain after operations.
JenaAges 18 years+ - NCT04636879Recruiting
Testing dry needling for neck pain expectations
This study looks at how people’s expectations and experiences relate to treatment with dry needling for neck pain. It may help researchers understand who benefits most from this therapy for upper trapezius muscle pain.
Alcalá de Henares, MadridAges 18–65 - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT04004286Recruiting
Pain registry and blood sample biobank for eligible service members
This trial is building a pain registry biobank to learn more about pain and how different people experience it. If you’re eligible for care in the Military Healthcare System and can consent, you may be able to contribute your information for future research.
San Diego, CaliforniaAges 18–80 - NCT07602595Recruiting
Early-life health risks and chronic pain in teens and young adults
This study looks at how early health problems might affect pain that lasts a long time. If you had a muscle or joint surgery, or a rheumatic disease, before age 18, you might help us understand why some people get ongoing pain.
Cincinnati, OhioAges 14–26 - NCT05492188Recruiting
Testing training and skin reflex changes for nerve pain after SCI
This study looks at how a training program affects skin reflexes and nerve pain in people with spinal cord injury (SCI). It may help researchers find better ways to manage nerve pain by changing how the body responds to touch and training.
Charleston, South CarolinaAges 18 years+ - NCT07524751Recruiting
Cultural Pain Management Program for Indigenous People
This study tests a pain management program designed specifically for American Indian and Alaska Native communities. If you have chronic pain (lasting over 3 months), this program teaches coping strategies that respect your culture and background.
Yakima, WashingtonAges 18 years+ - NCT06886906Recruiting
Movement and Pain in Older Adults
This study explores how movement and physical activity relate to pain in older adults with muscle or joint pain. It could help you understand your pain patterns and find better ways to manage them.
Indianapolis, IndianaAges 55–85 - NCT05563792Recruiting
Non-drug options for managing chronic pain
This study tests non-drug treatments for chronic pain in the back, neck, or joints. It aims to help people manage pain and improve daily function without relying on medications.
Indianapolis, IndianaAges 18 years+ - NCT04699734Recruiting
Nerve block for nerve pain from diabetes
This trial studies whether a numbing “nerve block” can reduce long-lasting nerve pain caused by diabetic neuropathy. You may keep your usual pain medicines, and the study will mainly check whether you fit the safety and diagnosis criteria.
Aarhus N, JutlandAges 18 years+ - NCT05981261Recruiting
Experimental pain study in Parkinson's and healthy adults
This study looks at how people with Parkinson’s, treated either with levodopa or deep brain stimulation (DBS), and healthy volunteers experience pain. The goal is to understand how Parkinson’s treatments affect pain perception.
AarhusAges Any age - NCT05726331Recruiting
Tai chi and chiropractic for long-term neck pain
This trial looks at whether a program of tai chi and chiropractic care can improve chronic, non-specific neck pain and daily function. It may help people who have had neck pain for months and want a structured exercise-and-care approach.
Chestnut Hill, MassachusettsAges 18–65 - NCT07856498Recruiting
Understanding pain and movement in postmenopausal women with low back pain
This study looks at how thoughts and fears about pain affect physical activity in women after menopause who have chronic low back pain. The goal is to learn more about these connections to help improve future treatments.
Istanbul, IstanbulAges 45–65 - NCT07866040Recruiting
Biofeedback exercises versus Mulligan method for neck pain
This trial compares two non-surgical treatments for ongoing neck pain: biofeedback exercises, which use sensors to help you learn to relax and strengthen neck muscles, and the Mulligan method, a hands-on technique that improves movement and posture. It aims to see which is better for reducing pain, improving mobility, and correcting posture in women.
Badr, Cairo GovernorateAges 18–45 - NCT06115083Recruiting
Pelvic floor training for men with chronic pelvic pain
This trial tests if pelvic floor muscle training can reduce chronic pelvic pain in men. It also looks at how well patient-reported symptoms match physical exam findings.
StockholmAges 18 years+ - NCT05458037Recruiting
Testing fast versus slow numbing during IUD or biopsy
This study compares two ways of applying a numbing tool (“tenaculum”) during an IUD insertion or an endometrial biopsy to see which one causes less pain. If you’re scheduled for one of these procedures, it may help improve how discomfort is managed.
Providence, Rhode IslandAges 18 years+ - NCT06413277Recruiting
ECAP-controlled spinal cord stimulation for chronic pelvic pain
This trial tests a new type of spinal cord stimulator that uses closed-loop technology to treat chronic pelvic pain caused by a known injury. It may be an option if your pain is severe and hasn't responded to other treatments.
New York, New YorkAges 18 years+ - NCT05768477Recruiting
Testing different treatments for chronic pain patients
This study looks at different ways to treat long-term (chronic) pain. You may be invited to participate if you’re an adult with chronic pain and can understand the study information.
GhentAges 18 years+ - NCT06393101RecruitingPhase 1
High-CBD cannabis extract for complex regional pain syndrome treatment
This study tests a high-CBD cannabis extract (BRC-002) to see if it can help reduce pain and improve health in people with Complex Regional Pain Syndrome (CRPS). Participants will not use opioids or other cannabis during the study.
La Jolla, CaliforniaAges 21–75 - NCT07836439Enrolling by invitation
Comparing two manual therapies for low back pain relief
This study compares two hands-on treatments, the Graston Technique and diacutaneous fibrolysis, to see which works better for reducing low back pain, improving function, and enhancing quality of life. If you have non-specific low back pain (pain without a clear cause), this trial may help you find a new way to manage your symptoms.
Sialkot, Punjab ProvinceAges 20–40
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.