Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05905146Recruiting
Personalized opioid plan to shorten treatment time
This trial tests whether a personalized medication plan can help patients with short-term, non-cancer muscle or joint pain need strong opioid medicine for a shorter time. It’s aimed at improving how long treatment lasts while still managing pain.
LilleAges 18 years+ - NCT07067710Recruiting
Imagery and movement study for breast cancer survivors
This study tests if visualizing and watching movements can help improve strength, motion, pain, and fear of movement in women who finished breast cancer treatment. It focuses on those with arm issues like pain, limited movement, or lymphedema.
Pamplona, NavarreAges 18 years+ - NCT07066709RecruitingPhase 2
Hip pain study after hip surgery
This study tests if a second hip surgery can help people who still have pain at least 6 months after their first hip surgery. It may help you if you have ongoing hip pain and haven't needed strong pain pills.
Madison, WisconsinAges 18–45 - NCT06860867Recruiting
Nucleus replacement for single-level discogenic low back pain
This trial tests a new device called PerQdisc for people with chronic low back pain from a single damaged disc in the lower spine. The goal is to see if the device can safely replace the inner gel of the disc without major surgery.
Glendale, ArizonaAges 22–70 - NCT04242589RecruitingPhase 2
Radiation plus bone cement for painful spinal metastasis pain
This trial tests adding a bone-cement procedure (vertebroplasty) along with radiation to reduce pain from cancer that has spread to the spine. It is for adults with painful metastatic (spread) tumors in the middle or lower spine, without current spinal cord pressure.
Edmonton, AlbertaAges 18 years+ - NCT07215780Recruiting
Sitz baths after pelvic organ prolapse surgery
This study compares sitz baths to regular care after surgery for pelvic organ prolapse. It aims to see if sitz baths can help reduce pain and improve recovery. If you are having prolapse repair surgery, you may be able to join.
Bridgeport, ConnecticutAges 18 years+ - NCT07297784Enrolling by invitation
Screen time and pain after tonsil removal in children
This study looks at whether children who use a lot of screens (like tablets, phones, or TV) feel more or less pain after tonsil surgery. It could help parents understand how media use affects recovery.
Tokat Province, Tokat ProvinceAges 4–11 - NCT07018219Recruiting
Finding the 7th neck bone by touch in neck pain patients
This trial looks at a simple way to find the 7th neck bone (cervical vertebra) by feeling it while you move your neck. It may help doctors better diagnose and treat neck pain.
ZagazigAges 18–60 - NCT07011069Recruiting
Comparing two pain blocks for lung surgery recovery
This trial tests two nerve-block methods to see which provides better pain control after minimally invasive lung surgery (VATS). If you qualify, you would receive one of the blocks to help reduce pain and possibly speed recovery.
Bursa, NiluferAges 18–80 - NCT06751160Recruiting
Dry needling vs. soft tissue massage for tight hamstrings
This study compares two treatments—dry needling and soft tissue massage—to see which works better for relieving tight hamstring muscles in people with low back pain.
Lahore, Punjab ProvinceAges 20–40 - NCT07010003Recruiting
Ear acupressure for anxiety and pain during heart surgery
This trial tests whether small ear acupressure beads can help reduce anxiety and pain in adults having planned heart surgery. The beads are placed on specific ear points and are easy to use.
StuttgartAges 18 years+ - NCT07746284Enrolling by invitation
Understanding knee osteoarthritis through computer modeling
This study looks at how knee osteoarthritis pain works and aims to build a computer model to better understand it. By joining, you may help doctors improve future treatments for chronic knee pain.
Herndon, VirginiaAges 18–99 - NCT06956950RecruitingPhase 2/Phase 3
Magnesium Added to Numbing Medicine for Hip Replacement Pain
This study tests whether adding magnesium sulfate to a numbing medicine (bupivacaine) can provide better pain relief after hip replacement surgery. The medicine is given as a shot in the back near the hip muscles.
Tanta, El-GharbiaAges 18 years+ - NCT06942806Recruiting
Spinal cord stimulation for shingles nerve pain
This trial tests a treatment called high-frequency short-time spinal cord stimulation for pain caused by shingles (herpes zoster). It's for people whose pain hasn't improved with other treatments or who can't take pain medicines due to side effects or other health issues.
Zunyi, GuizhouAges 40–85 - NCT06942611Recruiting
Electrical brain stimulation for chronic pain from nerve inflammation
This study tests a noninvasive brain stimulation technique (transcranial electrical stimulation) to see if it can reduce chronic pain in people with conditions like multiple sclerosis or neuromyelitis optica. It aims to offer a new, drug-free option for pain relief without major side effects.
BeijingAges 18–65 - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT06343714RecruitingPhase 1
Testing a new drug for knee osteoarthritis pain
This study tests a new antibody drug (FB1003) for people with knee osteoarthritis pain. It will check if the drug is safe and helps reduce pain. You may be eligible if you have moderate to severe knee pain and are willing to temporarily stop your usual pain medications.
Brisbane, QueenslandAges 18–75 - NCT07745127Recruiting
Nasal stitch versus packing after nose surgery
This study compares two ways to stop bleeding after nasal surgery (septoplasty): using a special stitch inside the nose versus using nasal packing. It aims to see which method is more comfortable and effective for patients like you.
Islamabad, FedralAges 18–50 - NCT06041321Recruiting
Testing a new sleeve for knee surgery recovery
This trial tests a special sleeve designed to help reduce pain and improve recovery after knee surgery for a torn meniscus. It may be a good option if you are having this type of knee surgery and are in generally good health.
Woodbury, New YorkAges 18–89 - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT05854914Recruiting
Smartphone hypnosis to reduce pain after emergency appendix surgery
This study tests whether guided hypnosis on a smartphone can lower pain after emergency surgery for a complicated appendicitis. If you qualify, you’ll use the app during your recovery and also answer quick questions about your pain and anxiety.
NiceAges 18 years+ - NCT05862454Recruiting
Magnesium shots may help avoid steroid during certain immune health issues
This trial studies whether giving a magnesium injection can replace (or avoid) steroids during treatment around times of vaccine, a viral infection, or immune system weakness. It targets adults with long-term (chronic) pain who already receive injection-based treatments and can reliably track symptoms.
Surrey, British ColumbiaAges 20–99 - NCT06888804Recruiting
Nerve block for chronic heel fracture pain
This study tests a non-surgical treatment (pulsed radiofrequency, or PRF) applied to a nerve in the ankle to see if it can reduce long-term pain after a heel bone (calcaneus) fracture. It may be an option if you have had pain for more than 3 months and other treatments haven't worked.
AnkaraAges 18–80 - NCT05657964Recruiting
Study of a back pain exercise program for chronic low back pain
This trial tests whether a structured exercise/education program can help people with chronic lower back pain. You may qualify if your pain and disability scores are high enough and you can complete study activities in English.
Redwood City, CaliforniaAges 18–65
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.