Clinical trials · Tennessee
Parkinson’s disease clinical trials in Tennessee
We’re tracking 21 recruiting parkinson’s disease studies with a site in Tennessee — including Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Tennessee
- NCT05357612RecruitingPhase 4
PET scan study for brain serotonin in neurodegenerative diseases
This study uses a special PET brain scan tracer to better understand serotonin receptor activity in people with certain neurodegenerative conditions, especially when they develop hallucinations or delusions. The results may help researchers improve how these brain changes are measured and tracked over time.
Nashville, TennesseeAges 50–85 - NCT06680830RecruitingPhase 2
Testing NEU-411 for early Parkinson's with LRRK2 gene change
This trial tests an experimental drug called NEU-411 for people with early Parkinson's disease who have a specific genetic change (LRRK2). It aims to see if the drug can slow the disease progression.
Nashville, TennesseeAges 40–80 - NCT07551661Recruiting
Walking With Poles for Parkinson Disease
This study tests whether using walking poles during regular walks helps people with Parkinson disease improve their movement and balance. You'll walk independently on your own schedule while using special poles designed to support your gait.
Johnson City, TennesseeAges Any age - NCT06944522RecruitingPhase 3
Cell therapy for Parkinson's symptoms
This study tests a new cell therapy called bemdaneprocel to see if it can reduce Parkinson's symptoms and “off” time. The treatment involves transplanting special cells into the brain to help replace lost dopamine-producing cells.
Nashville, TennesseeAges 45–75 - NCT07409207Recruiting
Brain signals and reward in Parkinson's surgery
This study looks at brain activity related to reward during deep brain stimulation (DBS) surgery to help us understand Parkinson's disease better. If you are having DBS surgery, your brain signals during the procedure may help researchers.
Nashville, TennesseeAges 40 years+ - NCT07174310RecruitingPhase 3
Prasinezumab for early Parkinson's disease
This study tests a new medication called prasinezumab, given through a vein (IV), to see if it can slow the progression of early-stage Parkinson's disease. It is for people who are on only one Parkinson's medication and have not yet developed motor complications.
Memphis, TennesseeAges 50–85 - NCT04994015RecruitingTeam says not enrolling
Genetic registry for people with Parkinson’s
This study builds a genetics “registry” of people diagnosed with Parkinson’s disease who agree to genetic testing. Your information may help researchers understand why Parkinson’s happens and improve future treatments.
Nashville, TennesseeAges 18 years+ - NCT04715984Recruiting
Testing brain-circuit targets during DBS surgery in Parkinson’s
This study looks at how brain connections involved in movement may relate to thinking and memory problems in Parkinson’s disease. It happens during a deep brain stimulation (DBS) operation, using tests while the surgeon is placing an electrode.
Nashville, TennesseeAges 40 years+ - NCT06285643RecruitingPhase 2
Gene therapy for moderate Parkinson's disease
This trial tests a gene therapy (AAV2-GDNF) to see if it can slow or improve symptoms of Parkinson's disease. It is for people who have had moderate Parkinson's for 4 to 10 years and still respond to levodopa therapy.
Nashville, TennesseeAges 45–75 - NCT07432958RecruitingPhase 2
Study of AP-472 with levodopa for Parkinson's motor fluctuations
This trial tests an experimental drug called AP-472, taken alongside your regular Parkinson's medications, to see if it can reduce the amount of "OFF" time you experience each day when symptoms return between doses of levodopa.
Nashville, TennesseeAges 30–80 - NCT04373317RecruitingPhase 4
Comparing two medicines for hallucinations in Parkinson's disease
This study compares two drugs, pimavanserin and quetiapine, to see which works better for hallucinations or delusions caused by Parkinson's disease. The goal is to help patients manage these symptoms more effectively.
Nashville, TennesseeAges 40 years+ - NCT01799915Recruiting
Study of causes and progression of synuclein-related nerve conditions
This study follows people over time to better understand “synucleinopathies,” which are conditions that affect the nervous system as it develops and progresses. You may be asked to return for visits and report symptoms, especially those that happen when you stand up.
Nashville, TennesseeAges 18 years+ - NCT04246437RecruitingPhase 1
Brain imaging study for autonomic failure with possible Parkinson disease
This Phase 1 study uses a special injected imaging tracer and an MRI scan to look at brain function in people with autonomic failure. It may help researchers understand what’s happening in conditions that can be related to Parkinson disease, multiple system atrophy, or dementia with Lewy bodies.
Nashville, TennesseeAges 18 years+ - NCT05292794Recruiting
CereGate therapy for freezing of gait in Parkinson’s
This trial tests whether CereGate therapy can reduce “freezing of gait,” a walking problem, in people with Parkinson’s disease who already have deep brain stimulation (DBS). If you meet the device and medication stability requirements, the study may help your walking and movement symptoms measured during testing.
Nashville, TennesseeAges 21–80 - NCT05489575Recruiting
CPAP machine for high blood pressure when lying down at night
This study tests whether using a CPAP breathing machine at night can lower high blood pressure that happens while you sleep. It targets people with nervous-system problems that affect blood pressure changes when standing.
Nashville, TennesseeAges 40–80 - NCT02897063RecruitingPhase 1
Test medicines for low blood pressure in nerve-related disorders
This early (Phase 1) study tests whether midodrine and droxidopa can improve blood-flow pooling in the belly in people with nerve problems that affect blood pressure when standing. It’s looking at safety and how the body responds, which may help reduce dizziness or fainting for some participants.
Nashville, TennesseeAges 40–80 - NCT01734122Recruiting
Focused radiation for essential or Parkinson tremor
This trial tests whether precisely targeted radiation to the brain can reduce tremors in people whose symptoms are not controlled enough by medication. It may help those who prefer radiation over deep brain surgery options.
Nashville, TennesseeAges 18 years+ - NCT02071134Recruiting
Registry study for Vercise deep brain stimulation patients
This study keeps a record of people who receive the Vercise deep brain stimulation system. It helps doctors learn how the treatment is used in real-world care and how patients do over time.
Nashville, TennesseeAges 18 years+ - NCT07428447Recruiting
Skin test to predict Parkinson's risk in essential tremor
This study uses a skin biopsy to check for a protein linked to Parkinson's disease. It aims to see if people with essential tremor who have this protein are more likely to develop Parkinson's disease.
Memphis, TennesseeAges 50–85 - NCT07284784RecruitingPhase 2/Phase 3
Buntanetap for Parkinson's disease study
This trial tests an investigational drug called buntanetap in people with Parkinson's disease. It aims to see if the drug can improve symptoms. There are two groups: those who've taken buntanetap before (Cohort 1) and those with a deep brain stimulator (DBS) implant for at least a year (Cohort 2).
Cordova, TennesseeAges 40–85 - NCT00575081Recruiting
Brain mapping during stereotactic procedures
This study builds a “brain atlas” by collecting information during stereotactic brain procedures. It may help doctors better plan and understand these brain procedures in the future.
Nashville, TennesseeAges 6–90
Parkinson’s disease trials by city in Tennessee
Where these studies are running in Tennessee
Institutions with a site for the recruiting parkinson’s disease studies listed above.
- Vanderbilt University Medical Center · 17 studies
- Veracity Neuroscience LLC · 3 studies
- East Tennessee State University
- Neurology Clinic, P.C.
- Tennessee Valley Healthcare System Nashville Campus
What taking part in a parkinson’s disease study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Parkinson’s disease trials in other states
Common questions
- Are there parkinson’s disease clinical trials in Tennessee?
- Yes. We're currently tracking 21 recruiting parkinson’s disease studies with a site in Tennessee, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a parkinson’s disease study in Tennessee?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Tennessee to take part?
- Not necessarily. These studies have a site in Tennessee, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a parkinson’s disease trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New parkinson’s disease studies open in Tennessee regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.