Clinical trials
Placebo clinical trials
Below are recruiting placebo clinical trials, each written for real people, not researchers. We’re tracking 5,158 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05714085RecruitingPhase 2/Phase 3
Vericiguat study for children with heart failure
This trial tests whether vericiguat helps children with chronic heart failure caused by weaker left heart pumping. It also checks safety and how the medicine behaves in the body (dose and processing).
Los Angeles, CaliforniaAges 4 weeks–17 years - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Escondido, CaliforniaAges 18 years+ - NCT05716100RecruitingPhase 3
Study drug for focal epilepsy that isn’t controlled on current meds
This trial tests XEN1101 compared with a placebo (inactive pill) in people with focal-onset seizures that haven’t been fully controlled despite trying at least two anti-seizure medicines. If you qualify, you may help researchers see whether the study drug reduces seizure frequency and improves control.
Little Rock, ArkansasAges 18 years+ - NCT05726292RecruitingPhase 2
Enzalutamide plus relacorilant versus placebo for high-risk prostate cancer
This study tests whether adding relacorilant to enzalutamide (a hormone-blocking treatment) helps control high-risk localized prostate cancer better than enzalutamide plus a dummy pill. It may help prevent the cancer from growing or spreading by targeting a hormone pathway in addition to standard treatment.
Chicago, IllinoisAges 18 years+ - NCT05674994RecruitingPhase 3
Steroid versus placebo for sudden worsening of lung scarring
This Phase 3 trial studies whether glucocorticoid (steroid) medicine helps people with idiopathic pulmonary fibrosis (IPF) who have a sudden flare-up, compared with an inactive placebo. You may be helped if steroids improve breathing and recovery during these acute episodes, but the study is designed to test that clearly.
AngersAges 18 years+ - NCT05684692RecruitingPhase 2
Pain-relief study for adults with schwannomatosis
This Phase 2 study tests whether an antibody medicine (either siltuximab or erenumab) can reduce moderate-to-severe pain in adults with schwannomatosis. It compares the medicine to a placebo and looks for improved pain control and tolerability.
Boston, MassachusettsAges 18 years+ - NCT05645107RecruitingPhase 3
XEMBIFY plus usual care to prevent infections
This Phase 3 study tests whether XEMBIFY (an immune protein therapy) plus standard medical treatment can better prevent serious or repeated infections. It is for people with certain cancers of blood/immune systems who are already having trouble with infections.
Bullhead City, ArizonaAges 18 years+ - NCT05640843Recruiting
Plant-based diet study for MGUS or smoldering myeloma
This trial tests whether a whole-food, plant-based eating pattern—plus supplements or placebo—can improve health outcomes in people with MGUS or smoldering multiple myeloma. You may be asked to follow specific recipes and stop certain supplements, so it helps to confirm you can stick with the plan.
Atlanta, GeorgiaAges 18 years+ - NCT05633810RecruitingPhase 3
Testing colchicine plus coated aspirin to prevent heart events
This Phase 3 study tests whether colchicine and a special type of aspirin can lower the risk of future heart attacks, strokes, or other major heart problems in people with type 2 diabetes who have not had a prior heart event. It aims to reduce cardiovascular risk using medicines that may calm inflammation and protect blood vessels.
Bentley, Western AustraliaAges 55–80 - NCT05586776RecruitingPhase 4
Using skin cleaning to prevent post-surgery wound infections
This trial tests a “skin decolonization” routine using medicated skin cleaning to help lower the risk of surgical site infections after abdominal surgery. You may be eligible if you recently had an open abdominal incision and your wound is healing as expected at discharge.
Newport Beach, CaliforniaAges 18 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05580562RecruitingPhase 3
ONC201 for newly diagnosed H3 K27M brain tumor after radiation
This study tests whether ONC201 (also called ONC201) can improve outcomes for people with a newly diagnosed H3 K27M–mutant diffuse brain tumor after they finish radiation. It looks for safety and whether treatment can help control the tumor.
Phoenix, ArizonaAges Any age - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT05424003RecruitingPhase 2
Semaglutide to prevent weight gain after liver transplant
This trial tests semaglutide (a diabetes/weight-loss medicine) to help prevent weight gain after liver transplant. It is also looking at blood sugar and safety while you continue your transplant medicines.
Richmond, VirginiaAges 18–75 - NCT05425355RecruitingPhase 4
IV versus oral acetaminophen after hip-fracture surgery
This trial compares giving acetaminophen (Tylenol) through a vein versus by mouth after hip-fracture surgery. It may help find which method works better for pain control and recovery in adults.
Toronto, OntarioAges 60 years+ - NCT05317819RecruitingPhase 3
Test ADI-PEG 20 versus placebo for advanced liver cancer
This study tests whether ADI-PEG 20 helps people with advanced, unresectable hepatocellular carcinoma (liver cancer) who have high arginine levels. Participants get ADI-PEG 20 or a placebo to see which works better and improves outcomes.
ChanghuaAges 18–99 - NCT05389930RecruitingPhase 2
Study how cannabis affects alcohol drinking
This Phase 2 study looks at whether using cannabis changes how much alcohol you drink. You may be able to take part if you’ve been drinking heavily and using cannabis recently and can meet health and screening requirements.
Providence, Rhode IslandAges 21–50 - NCT05327790RecruitingPhase 2
Fecal transplant to boost new biologic treatment for ulcerative colitis
This trial tests whether fecal microbiota transfer (a stool-based therapy) can improve outcomes when added to starting a new biologic medicine for ulcerative colitis. It compares fecal transplant versus placebo (a sham treatment) to see if symptoms and inflammation improve faster or more strongly.
Edmonton, AlbertaAges 18–75 - NCT05193396RecruitingPhase 4
Hydrocortisone trial for adrenal symptoms after stopping steroid pills
This trial tests whether hydrocortisone (a cortisol replacement) helps people who feel symptoms of adrenal insufficiency after they stop long-term prednisolone. It compares hydrocortisone versus placebo to see if symptoms improve and dosing is safer/effective.
AarhusAges 50 years+ - NCT05269628RecruitingPhase 2
Cannabidiol for multiple sclerosis sleep and pain patterns
This study looks at whether cannabidiol (CBD, a cannabis-related medicine) can improve symptoms in people with multiple sclerosis (MS), especially how sleep and pain type affect outcomes. It’s mainly for people with MS and ongoing moderate-to-severe pain, while carefully checking safety and medication interactions.
Ann Arbor, MichiganAges 18–65 - NCT05279742Enrolling by invitationPhase 1/Phase 2
Study drug to boost a hormone system in HFpEF
This early-phase trial tests a treatment that aims to improve the “natriuretic peptide” hormone system in people with HFpEF (heart failure with preserved pumping strength). It may help reduce symptoms and improve heart and fluid pressure behavior, especially in certain related conditions like kidney disease.
Rochester, MinnesotaAges 18 years+ - NCT05206955RecruitingPhase 3
Tadalafil versus placebo for Fontan circulation problems
This study tests whether tadalafil (a daily pill) can improve blood flow and protect organs in adults who have had Fontan surgery. Participants will either receive tadalafil or a placebo, and they will be monitored during a planned heart catheter procedure.
Rochester, MinnesotaAges 18 years+ - NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
Birmingham, AlabamaAges 18 years+ - NCT05120934RecruitingPhase 2
Two medicine doses to reduce ILD cough
This Phase 2 study tests whether two different doses of duloxetine and amitriptyline can reduce coughing caused by interstitial lung disease (ILD). If you have had a long-lasting ILD-related cough despite stable ILD treatment, this trial may help find a better way to control your cough.
Rochester, MinnesotaAges 18–75
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Common questions
- Are there clinical trials for placebo?
- Yes. Clin2 currently lists 5,158 recruiting placebo studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.