Clinical trials
Resistance clinical trials
Below are recruiting resistance clinical trials, each written for real people, not researchers. We’re tracking 1,200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07476001RecruitingPhase 2
High-dose testosterone and PSMA-targeted radiation for prostate cancer
This trial tests whether a short course of high-dose testosterone followed by a radioactive drug (PSMA-617) can help men with advanced prostate cancer that has stopped responding to hormone therapy. The goal is to make cancer cells more sensitive to the radiation.
Tampa, FloridaAges 18 years+ - NCT06206850RecruitingPhase 2
Study testing osimertinib before surgery for EGFR-mutant lung cancer
This trial tests if taking osimertinib before surgery can help treat a type of non-small cell lung cancer that has specific EGFR mutations. It aims to understand how the cancer may become resistant to this targeted therapy.
Ramat Gan, IsraelAges 18 years+ - NCT06242509Recruiting
Akkermansia bacteria in prostate cancer
This trial looks at whether a specific gut bacterium, Akkermansia muciniphila, is linked to how well hormone therapy works in men with advanced prostate cancer that no longer responds to standard hormone treatment. You may join if you are about to start a new type of hormone therapy.
ParisAges 18–100 - NCT06387667Recruiting
Fungal lung infections in ICU patients with weak immune systems
This study looks at different types of fungi that may cause serious lung infections in patients with weakened immune systems in the ICU. It aims to find out which fungi are present and which antifungal drugs can kill them.
AsyutAges 18 years+ - NCT07007910RecruitingPhase 1
Study of HSK46575 for advanced prostate cancer
This trial tests a new drug, HSK46575, for men with metastatic castration-resistant prostate cancer that has worsened after hormone therapy and chemotherapy. The goal is to see if it can help slow the cancer's growth.
Chengdu, SichuanAges 18 years+ - NCT06127290Recruiting
HIV treatment study for people in Eastern Europe and Russia
This study looks at how well newer HIV medicines work in people starting treatment for the first time in Eastern Europe and Russia. It also checks for drug resistance to find better treatment strategies.
CologneAges 18 years+ - NCT06792617Enrolling by invitationEarly Phase 1
Exercise for people on ECMO life support
This study tests if gentle exercise in bed can help people on ECMO (a life-support machine for heart and lungs) get stronger and recover faster. It is for adults in the ICU who are stable enough to move safely.
San Antonio, TexasAges 18 years+ - NCT06100705RecruitingPhase 2
Combination therapy for men with advanced prostate cancer
This trial tests combining an immunotherapy (Sipuleucel-T) with high-dose testosterone to see if it works better for men with castration-resistant prostate cancer that has spread.
New Haven, ConnecticutAges 18 years+ - NCT06490068RecruitingPhase 2
LTC004 with toripalimab for immunotherapy-resistant solid tumors
This trial tests a new combination of two drugs (LTC004 and toripalimab) for people with advanced solid tumors that have stopped responding to standard immunotherapy. It aims to see if this combination can help when immunotherapy alone no longer works.
BeijingAges 18–75 - NCT06641778Recruiting
Fecal transplant for drug-resistant Klebsiella pneumonia
This trial tests whether transplanting healthy donor stool into the lungs can help treat a severe pneumonia caused by a bacteria that is resistant to many antibiotics. It may offer a new option for people whose infection is not responding to standard treatments.
Wuhan, HubeiAges 18–75 - NCT07039370Recruiting
TMS for depression: looking for brain signals of response
This trial tests if brain scans or electrical signals can predict who will get better with TMS (transcranial magnetic stimulation) for depression. It is for people whose depression did not improve after trying two or more antidepressants.
Ankara, AnkaraAges 18–65 - NCT07005323Recruiting
New treatment for resistant wet AMD
This trial tests a new treatment for people with a hard-to-treat form of wet age-related macular degeneration (AMD) that has not improved with standard anti-VEGF injections. It aims to stop the disease from getting worse and possibly improve vision.
Ube, YmaguchiAges 50–85 - NCT07537010RecruitingPhase 1
3D1015 Injection for Advanced Prostate Cancer
This Phase 1 trial tests a new injectable treatment called 3D1015 for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The drug is designed to target cancer cells using a special imaging marker that shows up on PET scans.
Wuxi, JiangsuAges 18 years+ - NCT07369440Recruiting
Power training for fall risk in older adults
This study tests whether a community-based power training program can help reduce fall risk in older adults. It compares results for people who have fallen in the past year and those who haven't.
Maia, Porto DistrictAges 65 years+ - NCT07422181Recruiting
Ultrasound to see uterine blood vessels after birth
This study tests whether a special ultrasound with contrast dye can help doctors see the small blood vessels in the uterus right after birth. It may improve understanding of the uterus and help prevent bleeding.
VeldhovenAges 18 years+ - NCT07258576Recruiting
Birth control vs. natural cycle: muscle response to exercise
This study compares how muscle protein responds to resistance exercise in women who use birth control pills versus those with natural menstrual cycles. Participants will do exercise sessions and have muscle samples taken to see how their bodies build protein.
Toronto, OntarioAges 18–40 - NCT07259226RecruitingPhase 2
Studying resistance to antibody-drug conjugates in advanced cancer
This study is for people with advanced breast, bladder, lung, or stomach cancer who are about to start treatment with a type of targeted therapy called an antibody-drug conjugate (ADC). The trial will collect tumor samples and blood to understand how cancers become resistant to these drugs and to find better ways to predict treatment success.
VillejuifAges 18 years+ - NCT07110688Recruiting
Brain sensing study for mental states
This trial uses sensors and machine learning to understand mental states in healthy adults and people with epilepsy. Researchers aim to improve how we monitor and support mental health.
Downey, CaliforniaAges 18 years+ - NCT06770660Recruiting
Remote exercise for teen fitness
This trial tests whether exercising at home through video calls can improve heart and lung fitness in teenagers aged 12 to 17. It might be a convenient way to stay active if you cannot get to a gym or sports club.
SingaporeAges 12–18 - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60 - NCT05176483RecruitingPhase 1
New drug combinations for advanced solid tumors
This trial tests a new drug called zanzalintinib, which may slow or shrink various types of advanced cancer. It is given together with other cancer treatments, and the study is looking at many different cancers including kidney, prostate, bladder, lung, liver, and more.
Phoenix, ArizonaAges 18 years+ - NCT07200830RecruitingPhase 3
Testing different schedules of a targeted radiation drug for advanced prostate cancer
This trial tests two different dosing schedules of a drug called Lutetium-177 PSMA RLT, which delivers radiation directly to prostate cancer cells. It is for men with advanced prostate cancer that has stopped responding to hormone therapy and has spread, who have not yet had chemotherapy for this stage of the disease.
Anchorage, AlaskaAges 18 years+ - NCT06632977RecruitingPhase 2
Matching targeted treatments to your prostate cancer's genetics
This trial is testing whether matching your cancer's specific genetic changes to a targeted treatment can help control metastatic prostate cancer that has stopped responding to standard hormone therapy and chemotherapy. You may receive a drug, a radioactive treatment, or a combination based on your tumor's molecular profile.
Birmingham, AlabamaAges 18 years+ - NCT06982105RecruitingPhase 4
Comparing two antibiotics for children with MRSA bone or head infections
This study compares two oral antibiotics, TMP-SMX and clindamycin, to see which works better for children with MRSA infections in bones, joints, or head/neck areas. It aims to find the best treatment after initial IV therapy.
Indianapolis, IndianaAges 2 months–18 years
Hear when a new Resistance trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for resistance?
- Yes. Clin2 currently lists 1,200 recruiting resistance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a resistance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a resistance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.