Clinical trials
Respiratory Failure clinical trials
Below are recruiting respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 210 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06848218Recruiting
Music therapy during non-invasive breathing support for children
This study tests if music therapy can help children who are receiving breathing support (non-invasive ventilation) in the pediatric intensive care unit. It aims to reduce stress and discomfort during treatment.
MontpellierAges Up to 17 years - NCT06921655Recruiting
Using pressure and muscle measurement to avoid too much breathing help in the ICU
This study tests a new way to adjust the breathing machine settings for patients who are awake and breathing on their own but still need support. The goal is to avoid giving too much help, which can make the breathing muscles weak.
Trento, TrentoAges 18 years+ - NCT06996509Recruiting
Noninvasive breathing support for Guillain-Barré syndrome
This trial tests whether noninvasive breathing support (like a mask or nasal prongs) can help people with Guillain-Barré syndrome who have trouble breathing. It aims to see if this approach can avoid the need for a breathing tube.
Asyut, AssuitAges 18 years+ - NCT06996665Recruiting
High-flow nasal cannula based on diaphragm ultrasound
This study uses ultrasound to match high-flow oxygen settings to your diaphragm's movement. It looks at how breathing muscles respond at different flow rates to give you the best support.
Hangzhou, ZhejiangAges 18 years+ - NCT06996834Recruiting
Comparing breathing support methods for pneumonia-related breathing failure
This trial tests two noninvasive breathing support methods (NIV and HVNI) for people with pneumonia who are having trouble breathing. The goal is to see which method works better to help you avoid needing a breathing tube.
Asyut, AssuitAges 18 years+ - NCT07001696Recruiting
Predicting breathing support needs with chest X-ray and blood gas
This trial looks at whether combining a chest X-ray and a blood gas test can help doctors decide if a critically ill patient needs a breathing machine (mechanical ventilation). It aims to find a better way to make this important decision.
Zagazig, Al SharqiaAges 18 years+ - NCT07047092RecruitingPhase 3
CPAP vs. NIV for sleep apnea in COPD after breathing failure
This trial compares two breathing devices (CPAP and NIV) for people with both COPD and sleep apnea who recently needed breathing help in the hospital. The goal is to see which device works better at preventing future breathing emergencies.
ParisAges 18–84 - NCT07114289Recruiting
Breathing test methods for overweight patients on ventilators
This study compares two ways of testing if overweight or obese patients can breathe on their own after being on a ventilator. You will be randomly assigned to one of two breathing trials (pressure support or a T-piece) to see which works better for helping you get off the ventilator.
TaipeiAges 18 years+ - NCT07186933Recruiting
Ventilator settings to protect lungs during high-risk surgery
This study compares two ways of setting the ventilator during surgery to reduce lung complications. Researchers will test whether using a lower 'driving pressure' (a setting on the breathing machine) helps protect the lungs better than usual care. It is for adults having high-risk surgeries under general anesthesia with a breathing tube.
PátraiAges 18 years+ - NCT07247669Recruiting
AI phone triage for emergencies
This study tests if artificial intelligence can help identify time-sensitive emergencies like stroke, heart attack, or trouble breathing from recorded phone calls. The goal is to make emergency response faster and more accurate.
Málaga, MálagaAges Any age - NCT07324980Recruiting
Ultrasound for breathing trouble in the ER
This study tests if a quick ultrasound can help doctors figure out why you are having trouble breathing when you come to the emergency room. It may lead to faster and more accurate care.
NovaraAges 18 years+ - NCT07359261RecruitingPhase 2
Personalized breathing support for obese patients on a ventilator
This study tests a new way to adjust breathing machine settings to match each person's lungs, aiming to improve breathing for patients with obesity. It involves placing a small balloon in the esophagus to measure lung pressure and guide ventilator settings.
Edmonton, AlbertaAges 18 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT02299921Recruiting
Alcohol and drug effects on immunity in ICU breathing patients
This study looks at how alcohol and other drugs can affect the body’s immune system in people who are very sick in the ICU due to breathing problems. It may help doctors better understand immune changes during critical illness and respiratory failure.
Aurora, ColoradoAges 18–90 - NCT02464696Recruiting
Noninvasive breathing support to avoid tube breathing in cancer
This trial studies a mask-based breathing treatment (noninvasive ventilation) for people with cancer and serious breathing trouble, to see if it can prevent the need for intubation (putting a breathing tube in). If you qualify, the goal is to help you breathe better without invasive airway support when possible.
Houston, TexasAges 18 years+ - NCT07414108Recruiting
Predicting response to breathing support in COPD
This study looks at whether nighttime breathing problems can predict long-term success with a non-invasive breathing machine in people with COPD who have high carbon dioxide levels in their blood. The goal is to help doctors decide who will benefit most from this therapy.
BolognaAges 18 years+ - NCT07502677Recruiting
Can a sleep test detect breathing trouble in ALS?
This study tests a new wearable device called SleepImage to see how well it detects breathing problems during sleep in people with ALS. The goal is to catch early signs of respiratory failure before they become serious, helping doctors decide when to start breathing support.
LondonAges 18 years+ - NCT07503509Recruiting
Study of high PEEP in noninvasive ventilation
This study tests whether using higher pressure settings (PEEP) on a noninvasive breathing mask can help people with low oxygen levels. The doctors will measure the pressure inside your esophagus to guide the treatment.
Chongqing, Chongqing MunicipalityAges 18–100 - NCT07518862Recruiting
Using heart rate to guide oxygen therapy settings
This study uses a simple, non-invasive test (heart rate monitoring) to help doctors adjust the flow of oxygen therapy through a nasal cannula. It may help improve how well this breathing support works for you.
Toronto, OntarioAges 18 years+ - NCT07522450Recruiting
Sleep monitoring in critically ill patients on breathing support
This study measures sleep quality in patients hospitalized in intensive care who need help breathing. Researchers will use EEG (brain wave monitoring) to see if tracking sleep helps improve patient care and outcomes.
RouenAges 18 years+ - NCT07536750Recruiting
Comparing Two Sedation Drugs for ICU Patients on Breathing Support
This study compares two medications (ciprofol and propofol) used to keep ICU patients calm and comfortable while they receive non-invasive breathing support, such as oxygen masks or tubes that help them breathe without a breathing tube in their windpipe. Researchers want to see which drug works better and is safer.
Guangzhou, GuangdongAges 18 years+ - NCT07615010RecruitingPhase 2
agenT-797 Plus Standard Care for Severe Pneumonia With Respiratory Failure
This trial tests whether adding an experimental drug called agenT-797 to standard pneumonia treatment helps patients in the ICU who have severe pneumonia and serious difficulty breathing (acute hypoxemic respiratory failure). The drug is designed to help the immune system fight severe infection.
San Francisco, CaliforniaAges 18 years+ - NCT07313956Enrolling by invitation
Breathing machine method study in the ICU
This study looks at how different settings on the breathing machine (ventilator) are used for critically ill adults in the ICU. It may help doctors improve care for people who need a breathing tube.
Chicago, IllinoisAges 18 years+ - NCT06179485Enrolling by invitation
Ketamine vs. Etomidate for emergency breathing tube: long-term study
This study compares how two common medicines (ketamine and etomidate) used during emergency breathing tube placement affect long-term recovery. It is only for patients already enrolled in another related trial.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for respiratory failure?
- Yes. Clin2 currently lists 210 recruiting respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.