Clinical trials
Sepsis and Septic Shock clinical trials
Below are recruiting sepsis and septic shock clinical trials, each written for real people, not researchers. We’re tracking 87 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07179276Recruiting
Testing CO₂ gap to guide septic shock treatment
This trial checks if measuring the carbon dioxide gap (a sign of how well blood is flowing to organs) can help doctors improve treatment for people in septic shock. Septic shock is a severe infection that causes very low blood pressure and organ damage.
AngersAges 18 years+ - NCT05349370Recruiting
Track how lactate levels change in septic shock
This study measures how quickly a blood marker called lactate rises or falls in people with septic shock. It may help doctors understand which patterns are linked to recovery and guide better treatment decisions.
Stockholm, Stockholm CountyAges 18 years+ - NCT06990295Recruiting
Ultrasound spleen stimulation for sepsis shock
This trial tests if using focused ultrasound to stimulate the spleen can reduce inflammation in septic shock. It may help patients in the ICU who need strong blood pressure support.
Wuhu, AnhuiAges 18 years+ - NCT06904001Enrolling by invitation
Early warning model for sepsis in critically ill patients
This trial is building a tool to predict sepsis, a life-threatening response to infection, in intensive care patients. It may help doctors act faster to prevent complications.
Wenzhou, ZhejiangAges 18–99 - NCT06881927RecruitingPhase 4
Reducing anti-rejection meds in ICU for kidney transplant patients
This study tests whether quickly reducing your anti-rejection medicines during a life-threatening ICU stay can help your kidneys recover and improve your overall outcome. It is for kidney transplant recipients with septic shock or severe breathing failure.
StrasbourgAges 18 years+ - NCT06184659RecruitingPhase 4
Comparing two antibiotics for sepsis in critical illness
This trial compares two common antibiotics, meropenem and piperacillin/tazobactam, to see which works better for adults with sepsis who are critically ill. It aims to help doctors choose the best treatment for serious infections.
Copenhagen, København ØAges 18 years+ - NCT06832436Recruiting
Atrial strain study in septic shock patients
This study looks at how well the upper chambers of the heart (atria) work during septic shock using a special heart ultrasound. It may help doctors understand how the heart is affected by severe infections.
SalouëlAges 18 years+ - NCT06287684Recruiting
Sepsis treatment study based on genetic subtypes
This study looks at how different genetic types of sepsis affect treatment. It aims to find better therapies for your specific sepsis subtype.
MsidaAges 18 years+ - NCT06809868Recruiting
Study of genetic elements in sepsis and aging
This trial looks at how certain genetic elements may affect the immune system in older adults with sepsis. It aims to understand why older patients may respond differently to severe infections.
San Francisco, CaliforniaAges 18 years+ - NCT06808100Enrolling by invitation
Can a blood test predict organ failure in septic shock?
This trial is studying a blood marker called GDF-15 to see if it can predict which patients with septic shock might develop multiple organ failure. If you have septic shock and do not have certain other serious health conditions, you may be able to join.
AnkaraAges 18 years+ - NCT06709573RecruitingPhase 4
Early vs. late vasopressin for septic shock
This study compares giving vasopressin earlier vs. later to patients with septic shock who are already on norepinephrine. The goal is to see if adding vasopressin sooner helps improve blood pressure recovery.
Cleveland, OhioAges 18 years+ - NCT06692036Enrolling by invitation
Blood filtering for septic shock
This trial tests a special blood-filtering method (adaptive blood purification) for people with septic shock caused by a severe infection. It aims to see if this treatment can help control inflammation and improve recovery in the ICU.
Beijing, Beijing MunicipalityAges 18–82 - NCT04748796RecruitingPhase 3
Landiolol to prevent death in ventilated septic shock patients
This trial tests whether landiolol (a short-acting heart-rate–lowering medicine) can reduce deaths compared with standard care in people in septic shock who have a fast heart rate and strong heart pumping. It is meant for a very specific type of critically ill patient while they are on a breathing machine.
AmiensAges 18 years+ - NCT06446947Recruiting
Blood markers for poor outcomes after sepsis in cancer surgery
This study looks at blood markers (epigenetics) to better understand why some people have a harder time recovering from a severe infection after major cancer surgery. The goal is to find early signs of poor outcomes in men aged 45–75 with post-surgery sepsis.
Marseille, Bouches du RhôneAges 45–75 - NCT05975671Recruiting
Survey in pediatric ICU to reduce upfront vancomycin use
This study is a survey and quality-improvement effort in participating children’s intensive care units. It aims to understand and change how doctors decide to start vancomycin (an antibiotic) when sepsis is suspected, to improve care and avoid unnecessary use.
Atlanta, GeorgiaAges Any age - NCT06178822Recruiting
New blood tests to diagnose sepsis in the ER
This study aims to find new ways to quickly diagnose sepsis (a severe response to infection) in patients arriving at the emergency room. If successful, these new tests could help doctors start treatment faster.
Almere Stad, FlevolandAges 18 years+ - NCT03401398RecruitingPhase 3
Hydrocortisone for children with septic shock in the ICU
This Phase 3 trial tests whether giving stress-dose hydrocortisone can improve outcomes for children with septic shock in the pediatric intensive care unit (PICU). It is designed for children who are already receiving strong medicines to support blood pressure because of a serious infection.
Tucson, ArizonaAges 1 month–17 years - NCT05383963Recruiting
Using ICU routine data to diagnose sepsis sooner
This study checks whether information collected routinely in the ICU can help doctors recognize sepsis or septic shock earlier. If it works, it may improve how quickly diagnosis happens and potentially outcomes for patients.
BerlinAges 18 years+ - NCT05304728Enrolling by invitation
Hospital sepsis decision support program enrollment study
This study tests a computer system meant to help doctors recognize and manage sepsis (a serious body-wide response to infection) when people come to the emergency department or are admitted to the hospital. If you’re evaluated in a hospital setting for possible sepsis, you may be included to help improve care decisions.
Irvine, CaliforniaAges 18–89 - NCT05148286RecruitingPhase 4
Testing albumin vs fluids for septic shock in the ER
This trial tests whether giving albumin instead of standard crystalloid fluids helps adults with septic shock. It may improve how well your body circulates blood and reduces strain on organs.
SeoulAges 18 years+ - NCT04855786Recruiting
Drain lymph fluid to reduce inflammation in septic shock
This study tests whether draining fluid from a chest lymph channel can lower inflammation chemicals (cytokines) in people with septic shock. It’s done using a procedure and aims to see if this helps stabilize the body’s inflammatory response.
Philadelphia, PennsylvaniaAges 18–80 - NCT04494074Recruiting
Cooling fever in ventilated people with septic shock
This study tests whether external cooling can safely lower very high fever in people who are on a breathing machine for septic shock. It may help improve outcomes by controlling fever while they are treated for the infection causing their illness.
AmiensAges 18 years+ - NCT04203979Recruiting
Sepsis care tailored to patients
This study looks at how to better recognize and manage sepsis (a serious body-wide reaction to infection) and tailor care to the individual. You may be eligible if you are newly admitted to the emergency department and your care is handled by a rapid response team for sepsis.
OsloAges 18 years+ - NCT06140147Recruiting
Reducing fluids in septic shock care
This study tests if giving fewer fluids (other than the fluids to keep blood pressure up) can help people recover from septic shock. It compares a reduced fluid strategy to the usual care in the ICU.
HelsinkiAges 18 years+
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Common questions
- Are there clinical trials for sepsis and septic shock?
- Yes. Clin2 currently lists 87 recruiting sepsis and septic shock studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sepsis and septic shock trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sepsis and septic shock trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.