Clinical trials
Sepsis and Septic Shock clinical trials
Below are recruiting sepsis and septic shock clinical trials, each written for real people, not researchers. We’re tracking 87 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05928767Recruiting
Using frailty scores to predict death in ICU sepsis
This trial checks whether a “frailty” rating (how physically/mentally vulnerable someone is) can predict the risk of death in ICU patients with sepsis shock. It may help doctors identify higher-risk patients earlier and tailor care.
BéthuneAges 18–65 - NCT06766461RecruitingPhase 4
Optimizing antibiotic dosing in ICU patients with septic shock
This trial checks if giving higher doses of beta-lactam antibiotics (a type of strong antibiotic) right from the start helps people in the ICU with septic shock. It aims to find the best dose to fight the infection quickly.
RotterdamAges 18 years+ - NCT06937918Recruiting
Fluid management guide for septic shock patients
This study tests a computer software that helps doctors decide how much fluid to give patients in septic shock. It aims to improve blood pressure and oxygen delivery without causing fluid overload.
Bangkok Noi, BangkokAges 18 years+ - NCT07807410Recruiting
Special dialysis filter for septic shock with kidney failure
This study tests whether using a special filter (oXiris) during dialysis can better remove harmful toxins from the blood in people with septic shock and kidney failure, potentially helping them recover faster.
Guangzhou, GuangdongAges 18 years+ - NCT04288635Recruiting
Testing a nutrient supplement for energy problems in septic shock
This study looks at whether a metabolite (nutrient) supplement can help the body’s cells work better when someone is in septic shock. It is done in the ICU, and it may benefit people with sepsis who still have poor circulation and high lactate levels despite standard treatment.
Angers, Maine et LoireAges 18 years+ - NCT06062303Recruiting
Capillary refill time to guide septic shock treatment
This trial tests a new way of giving fluids and medicines to people with septic shock. It focuses on a simple sign called capillary refill time (how fast color returns when you press a fingernail) to guide treatment, aiming to improve recovery.
ReimsAges 18 years+ - NCT06915974Recruiting
Comparing Blood Tests for Sepsis in Burn ICU Patients
This study is comparing two blood tests (Interleukin 6 and Procalcitonin) to find which is better at detecting sepsis (a serious infection) and predicting the risk of death in burn patients in the ICU. If you have moderate burns and are otherwise healthy, this trial could help improve care for burn victims.
CairoAges 25–60 - NCT07863323Recruiting
Guided fluid therapy for sepsis in internal medicine
This study tests whether using a non-invasive monitor to guide fluid and medication decisions helps people with sepsis recover better than standard care. It aims to improve blood flow and organ function without extra needles or procedures.
Pisa, PisaAges 18 years+ - NCT05688774Recruiting
Study of worsening community pneumonia in people with weaker immunity
This study follows how community-acquired pneumonia progresses in hospitalized patients who already have serious health problems or weakened immune systems. The goal is to better understand risk and changes over time, which may help guide future care for people like you.
BerlinAges 18–99 - NCT07779720Recruiting
Personalized fluids for emergency sepsis care
This trial tests a personalized approach to giving IV fluids to patients with sepsis in the emergency department. It uses a device to monitor your heart and blood flow to help doctors decide how much fluid you need, which may improve recovery.
Murray, UtahAges 18 years+ - NCT03892174Recruiting
Removing inflammatory signals during heart surgery for endocarditis
This study tests whether removing certain inflammation signals (cytokines) can help people with severe heart infection (infective endocarditis) who are having heart surgery soon. It may help reduce harmful inflammation around the time of surgery, but it also has several medication and health-condition requirements.
BernAges 18 years+ - NCT07419802Recruiting
Study of a special filter for septic shock patients
This trial tests a special blood filter called Oxiris that may help remove toxins and inflammation from the blood in patients with septic shock. It aims to see if this treatment can improve outcomes for people who need kidney replacement therapy.
RigaAges 18 years+ - NCT06754696Recruiting
Testing a blood protein in children with and without infection
This study looks at a specific blood protein level in children from birth to age 17. It compares healthy children and those with sepsis to see if the protein changes during infection.
NantesAges Up to 17 years - NCT07367113Recruiting
Finger sensor guided fluids for skin health in older ICU patients
This study tests if using a finger sensor to guide fluid therapy can prevent skin failure in older ICU patients with sepsis or shock. It compares usual care to personalized fluid management.
Nantong, JiangsuAges 65 years+ - NCT07343206Recruiting
Early norepinephrine for sepsis with low blood pressure
This trial tests whether giving a medicine called norepinephrine early and adjusting the dose quickly can help people with sepsis who have very low blood pressure. It is for adults who are diagnosed within the last 3 hours and who have not already received this medicine.
Bangkok Noi, BangkokAges 18 years+ - NCT07067866RecruitingPhase 3
Best way to stop vasopressin in sepsis patients
This trial compares two ways to safely stop the vasopressin medication in people with sepsis who are in the ICU. It aims to find the best approach to wean off this blood pressure support, which could help you recover more smoothly.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06634069RecruitingPhase 2
Testing a new approach for septic shock patients
This trial tests a special fluid management strategy for people in septic shock—a serious infection that causes very low blood pressure. It aims to improve blood flow to organs and help you recover.
Pilsen, Czech RepublicAges 18–90 - NCT06464510RecruitingPhase 3
Treating sepsis with norepinephrine plus early vasopressin
This trial tests whether giving a second medicine called vasopressin early (along with norepinephrine) helps people with sepsis and low blood pressure better than waiting to use vasopressin only if norepinephrine doesn't work. It may improve blood pressure control and reduce the need for strong medicines.
Caxias do Sul, Rio Grande do SulAges 18 years+ - NCT03992378Recruiting
Nerve stimulation to calm inflammation in sepsis
This trial tests a form of nerve stimulation to help control the body’s overactive inflammation and “autonomic” nervous system imbalance during sepsis. It may help stabilize blood pressure and reduce complications, depending on the cause of your symptoms.
Oklahoma City, OklahomaAges 18 years+ - NCT03334006RecruitingPhase 2
Tested special immune-targeting treatment after abdominal infection surgery
This Phase 2 study tests whether Pentaglobin®, a blood-product made from immune proteins, helps critically ill people with severe abdominal infection (peritonitis) after the infection source is surgically cleaned up. It targets patients with signs of strong inflammation and severe illness.
ViennaAges 18 years+ - NCT06680180Recruiting
Blood Clot Breakdown in Severe Infection and Injury
This trial studies how well the body's natural clot-busting system works in people with serious infections or major injuries. It may help doctors find better ways to treat these conditions.
Canberra, Australian Capital TerritoryAges 18 years+ - NCT07063095RecruitingPhase 3
Testing two antibiotics combined for serious bacterial infections
This study tests whether combining two antibiotics (ceftazidime and fosfomycin) works better than ceftazidime alone for hospitalized adults with serious bacterial infections. If you have a severe infection thought to be caused by Gram-negative bacteria, this trial may offer a new treatment option.
Geneva, Canton of GenevaAges 18 years+ - NCT07136532Recruiting
Predicting fluid needs in children with septic shock using ultrasound
This study tests whether using ultrasound of the neck (carotid artery) and heart can help doctors know which children with septic shock need more fluids. It aims to make fluid treatment safer and more precise in the pediatric intensive care unit (PICU).
CairoAges 1 month–16 years - NCT07286643Recruiting
Ultrasound-guided sepsis care for patients with cirrhosis
This study tests whether using a special ultrasound of the heart can guide treatment for sepsis-related low blood pressure in patients with cirrhosis. It aims to improve care and outcomes for critically ill patients.
ChandigarhAges 18–65
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Common questions
- Are there clinical trials for sepsis and septic shock?
- Yes. Clin2 currently lists 87 recruiting sepsis and septic shock studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sepsis and septic shock trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sepsis and septic shock trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.