Clinical trials
Sepsis clinical trials
Below are recruiting sepsis clinical trials, each written for real people, not researchers. We’re tracking 268 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04580680Recruiting
Testing a blood-filter treatment in critically ill ICU patients
This study looks at an add-on blood-filter treatment used in the ICU to help remove harmful substances like waste products, inflammation signals, or toxins from the blood. Results may help doctors understand whether this approach improves care and how it should be used.
FlorenceAges Any age - NCT04615065Recruiting
Biobank study collecting emergency data for very sick patients
This study collects health and sometimes blood sample information from people arriving at the emergency department with high-risk or serious conditions. The goal is to build a large emergency “biobank” to help researchers better understand and improve urgent care.
GroningenAges 18 years+ - NCT04794595Recruiting
Compare outcomes in children with and without CBP during sepsis
This study looks at children with sepsis to see how outcomes differ between those who receive a specific blood-cleansing treatment (CBP) and those who do not. Results may help clinicians choose treatments that lead to better recovery in sick children.
Shanghai, Shanghai MunicipalityAges 4 weeks–18 years - NCT04843982RecruitingPhase 4
Esketamine to reduce inflammation in septic adults
This trial studies whether esketamine can improve the body’s overactive inflammation during sepsis. Participants are adult ICU patients who are sick enough to need breathing support and have higher severity scores.
Wuhan, HubeiAges 18–80 - NCT04850456Recruiting
Gamma globulin treatment for critically ill children with inflammation surge
This trial studies whether giving “human gamma globulin” can improve outcomes in very sick children in the ICU who have a severe infection causing an extreme inflammation reaction (“inflammatory storm”). If you’re in the hospital ICU with this complication, the study may offer a targeted treatment strategy and careful monitoring.
Shanghai, Shanghai MunicipalityAges 4 weeks–18 years - NCT04855786Recruiting
Drain lymph fluid to reduce inflammation in septic shock
This study tests whether draining fluid from a chest lymph channel can lower inflammation chemicals (cytokines) in people with septic shock. It’s done using a procedure and aims to see if this helps stabilize the body’s inflammatory response.
Philadelphia, PennsylvaniaAges 18–80 - NCT04886284RecruitingPhase 2
Cefazolin plus ertapenem for MSSA bloodstream infection
This Phase 2 study tests whether adding ertapenem to cefazolin can improve treatment of staphylococcus (“S. aureus”) bloodstream infection that is likely methicillin-susceptible (MSSA). It aims to start the right antibiotics quickly, before MRSA status is fully confirmed, using early testing and a treatment plan guided by infectious-disease specialists.
Calgary, AlbertaAges 18–100 - NCT04961580Recruiting
Study of ceftazidime dosing in sick children
This trial measures how ceftazidime (an antibiotic) moves through the body and how it works in children with severe infections in the pediatric intensive care unit. It may help doctors choose safer, more effective dosing for kids.
Shanghai, Shanghai MunicipalityAges 3 months–18 years - NCT05044403Recruiting
Hemoperfusion for severe sepsis causing multiple organ failure
This study tests whether a blood-filter treatment called hemoperfusion can help critically ill people with sepsis that is not responding to standard shock treatment and is affecting multiple organs. It aims to improve recovery when infections are controlled and inflammation markers are very high.
Castellon, CastellónAges 18–80 - NCT05146336Recruiting
CytoSorb registry for critically ill patients needing blood treatment
This registry collects information about critically ill patients who receive the CytoSorb 300 mL blood treatment. It may help doctors better understand when the treatment works best and when it should not be used.
KlagenfurtAges Any age - NCT05181696Recruiting
Study of chest X-ray severity scores in ICU COVID-19 pneumonia
This study reviews past chest X-rays from people who were hospitalized in the ICU for COVID-19 pneumonia caused by SARS-CoV-2. It aims to see how well a chest X-ray severity scoring system reflects how sick the lungs were.
OsijekAges 18–90 - NCT05261607Recruiting
Study outcomes for people in the intensive care unit
This study looks at how mortality (whether patients survive) changes over time for people treated in an intensive care unit. It may help hospitals understand what happens to ICU patients and improve care planning.
Getafe, MadridAges Any age - NCT05304221Recruiting
Test an electronic tool to calculate antibiotic resistance
This trial checks whether an electronic “resistance calculator” helps clinicians choose antibiotics for adults hospitalized with suspected sepsis. It compares outcomes when hospitals use the tool versus usual practice to see if antibiotic decisions improve care.
Be’er Ya‘aqovAges 18 years+ - NCT05336851Recruiting
Emergency breathing test study for sudden lung infections
This trial tests an emergency breathing-related approach for adults with a sudden, community-acquired respiratory infection. It may help doctors quickly sort out what’s going on and guide early care.
Hong KongAges 18–100 - NCT05349370Recruiting
Track how lactate levels change in septic shock
This study measures how quickly a blood marker called lactate rises or falls in people with septic shock. It may help doctors understand which patterns are linked to recovery and guide better treatment decisions.
Stockholm, Stockholm CountyAges 18 years+ - NCT05357170Recruiting
Testing gut bacteria changes after severe ICU illnesses
This study looks at changes in the microbiome (gut bacteria) in adults after serious ICU illnesses like sepsis, major trauma, or open heart/abdominal surgery. It may help researchers understand why recovery can be harder in some people and guide future treatments.
Gainesville, FloridaAges 18–110 - NCT05442710RecruitingPhase 2
Immune cell treatment for recovery from severe septic shock
This trial tests an immune-cell treatment given outside the body to help people recover from septic shock, a life-threatening reaction to infection. It aims to improve survival and organ recovery in patients who are still very ill despite standard care.
Freiburg im Breisgau, Baden-WurttembergAges 18 years+ - NCT05565222RecruitingPhase 3
Testing two antibiotics as alternatives for ICU severe ESBL infections
This study compares two antibiotics—piperacillin-tazobactam or temocillin—to treat severe ICU infections caused by certain hard-to-treat gut bacteria (ESBL). It may help patients avoid the use of carbapenem antibiotics like meropenem when the bacteria are susceptible.
ParisAges 18 years+ - NCT05591924Recruiting
Bioinformatics study in adults with very early severe ICU illness
This trial studies how early severe illness in the ICU can be understood and tracked using health data (bioinformatics/informatics). It may help improve care decisions for people who arrive to the ICU soon after an emergency department visit.
London, OntarioAges 18 years+ - NCT05604846Recruiting
Probiotic drops for very preterm babies in Scandinavia
This trial studies whether giving probiotic supplements to extremely preterm newborns helps improve health outcomes. It’s meant for babies born very early, and the results could help guide safer early nutrition and care.
Solna, Stockholm CountyAges 5 months–6 months - NCT05623722Recruiting
Nerve block to help organ function in severe gut sepsis
This trial studies whether an erector spinae plane nerve block (a pain-control injection near the spine) can improve organ health in adults with sepsis caused by acute gut injury. It’s meant for people sick enough to need ICU care for several days.
Guangzhou, GuangdongAges 18 years+ - NCT05688774Recruiting
Study of worsening community pneumonia in people with weaker immunity
This study follows how community-acquired pneumonia progresses in hospitalized patients who already have serious health problems or weakened immune systems. The goal is to better understand risk and changes over time, which may help guide future care for people like you.
BerlinAges 18–99 - NCT05692011Recruiting
Testing a blood-filter treatment in children with early sepsis
This trial looks at whether a blood-filter treatment (called “AN69ST Verse PS” using a hemofilter) can help children with early, serious sepsis and poor circulation or organ problems. It may help stabilize the body faster, but eligibility is limited to certain sepsis situations and recent timing.
Shanghai, Shanghai MunicipalityAges 4 weeks–28 years - NCT05694624Recruiting
Study of sepsis-related kidney injury monitoring
This trial looks at acute kidney injury that can happen during sepsis (a serious body-wide infection or suspected infection). It may help improve how doctors detect and manage kidney problems early, especially in intensive care or around major surgery.
Tromsø, TromsAges 18–100
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Common questions
- Are there clinical trials for sepsis?
- Yes. Clin2 currently lists 268 recruiting sepsis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sepsis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sepsis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.