Clinical trials
Weaning clinical trials
Below are recruiting weaning clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07019636Recruiting
Direct extubation vs. extubation after a breathing trial
This study compares two ways of removing the breathing tube (extubation) in patients who are ready to breathe on their own: taking the tube out right away, or doing a trial of breathing without the machine first. It is for people who are at low risk of needing the tube put back in.
ParisAges 18–65 - NCT06683781Recruiting
Breathing machine settings and weaning success study
This study looks at how breathing machine settings and monitoring can help predict if a patient will successfully come off the ventilator. It may help doctors choose better settings for patients who are ready to try breathing on their own.
Buenos AiresAges 18–100 - NCT07120672Recruiting
Breathing tube removal success study
This study tests if a new method (PPI) can better predict when a patient is ready to have their breathing tube removed after a trial of spontaneous breathing.
IstanbulAges 18 years+ - NCT06923267Recruiting
Ultrasound to check heart function during breathing trials
This trial tests if using ultrasound to monitor your heart during a breathing test can help predict if you will need the breathing tube again. It is for people on a ventilator for at least 24 hours who are at higher risk of needing the tube reinserted.
OrléansAges 18 years+ - NCT06499389Recruiting
Breathing muscle therapy for hard-to-wean ICU patients
This study tests a special breathing therapy for intensive care patients who are having trouble coming off the ventilator. If you have weak muscles or a weak cough, the therapy aims to strengthen your breathing so you can recover faster.
Lyon, FranceAges 18 years+ - NCT07383051Recruiting
Helping children breathe on their own after ventilator support
This trial tests whether a special type of high-flow nasal therapy can help children come off a breathing machine (ventilator) more successfully. It compares standard care with this extra support to find what works best for kids ages 2 months to 13 years.
Cairo, Cairo GovernorateAges 2 months–13 years - NCT05640635Recruiting
Testing inflammation changes in people on ECMO
This study looks at inflammation during ECMO (a heart-lung bypass machine) and while people are being weaned off it. It may help doctors better understand which patients are improving safely during ECMO and when to reduce support.
Tübingen, Baden-WurttembergAges 18 years+ - NCT05922982Recruiting
Guided medicine weaning for low blood pressure after heart surgery
This study tests a method to safely reduce (wean) norepinephrine, a blood-pressure–support medicine, in people who develop low blood pressure after heart surgery. It uses a monitoring index to help decide when it may be safer to lower the dose, aiming to improve recovery and reduce risks.
AmiensAges 18 years+ - NCT06776939Recruiting
High-flow oxygen through trach tube to help weaning from a ventilator
This trial tests if high-flow oxygen delivered through a tracheostomy tube can make mucus less sticky and reduce breathing effort while you are being taken off a ventilator. It could help you breathe easier during weaning.
RotterdamAges 18 years+ - NCT07067866RecruitingPhase 3
Best way to stop vasopressin in sepsis patients
This trial compares two ways to safely stop the vasopressin medication in people with sepsis who are in the ICU. It aims to find the best approach to wean off this blood pressure support, which could help you recover more smoothly.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07202299Recruiting
Weaning preterm babies off high-frequency breathing machines
This trial tests two different ways to safely take preterm babies off a special breathing machine (HFOV). It aims to find which method works better for babies with breathing problems (respiratory distress syndrome).
Al MansurahAges Any age - NCT07571317Recruiting
Predicting breathing tube removal success in ICU patients
This study tests whether two simple breathing measurements can predict whether patients in the ICU are ready to have their breathing tube removed. If successful, it could help doctors make safer decisions about when patients can breathe on their own.
Istanbul, IstanbulAges 18 years+ - NCT07751237Recruiting
Ultrasound of the diaphragm during breathing machine weaning
This study uses ultrasound to look at how well your diaphragm (the main breathing muscle) is working while you are on a breathing machine. The goal is to see if this can help doctors predict when you can safely breathe on your own and leave the ventilator sooner.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06465082Recruiting
Can diaphragm ultrasound predict successful breathing tube removal?
This trial uses ultrasound to measure how well your diaphragm (the main muscle you use to breathe) thickens when you breathe in. The goal is to see if this measurement can help doctors decide the best time to remove the breathing tube safely.
Al MansurahAges 18 years+ - NCT06391424Recruiting
Oxygen use and breathing effort during ventilator weaning
If you are on a breathing machine in the ICU and ready to try breathing on your own, this study looks at how much oxygen your body uses during that test. It may help doctors better understand when you are ready to come off the ventilator.
Leiden, South HollandAges 18 years+ - NCT06321133Recruiting
Weaning babies off high-flow oxygen for bronchiolitis
This trial tests whether babies with bronchiolitis who have been on a high-flow nasal cannula (a breathing tube) for at least 12 hours can safely stop it. It aims to find a better way to wean babies off this breathing support.
JoensuuAges birth–1 year - NCT04658498Recruiting
Respiratory muscle training to help patients come off the ventilator
This trial studies whether exercises for breathing muscles can help people who are having a hard time coming off a breathing machine in the ICU. It may help you breathe with less ventilator support once your body is stable enough.
LeuvenAges 18 years+ - NCT07109570Recruiting
Checking breathing effort in ICU patients on a ventilator
This trial measures how your breathing muscles work while we try taking you off the breathing machine. The results could help doctors predict when you're ready to breathe on your own.
LeidenAges 18 years+ - NCT03657524Recruiting
Ultrasound heart imaging to help predict trouble weaning off a ventilator
This study uses a special ultrasound of the heart to help predict whether you might fail a trial of breathing on your own after being on a breathing machine. If the test can predict trouble early, clinicians may choose safer weaning plans.
MarseilleAges 18 years+ - NCT06123143Recruiting
Finding the best time to stop CPAP in very small babies
This study looks at when to safely take very small babies (born before 30 weeks) off breathing support called CPAP. It aims to find the ideal time to help their lungs grow stronger.
Escondido, CaliforniaAges Up to 7 months - NCT07075926Recruiting
Heart ultrasound to predict breathing tube removal success in ICU
This study uses a heart ultrasound to see if it can help doctors predict when patients in the ICU are ready to have their breathing tube removed. It may help avoid failed extubations and reduce complications.
Istanbul, IstanbulAges 18 years+ - NCT07638293Recruiting
High-Flow Oxygen Therapy Weaning Protocols for Respiratory Failure
This trial compares two different approaches to gradually reducing high-flow nasal oxygen therapy (a breathing support treatment delivered through your nose) in patients with acute respiratory failure. The goal is to find the best way to safely stop this treatment and transition you to breathing on your own.
Milan, LombardyAges 18 years+ - NCT07559591Recruiting
High-Flow Oxygen to Help Breathing Tube Patients
This study tests whether high-flow oxygen through a breathing tube helps patients recover faster after tracheostomy (a surgical opening in the windpipe). If you're in the ICU with a tracheostomy and nearly ready to breathe on your own, this trial may help you transition off the ventilator more smoothly.
RiyadhAges 18 years+ - NCT07073976Recruiting
Predicting success of coming off the breathing machine using heart ultrasound
This study uses an ultrasound of the heart (echocardiogram) to check how well the right side of your heart is working. The goal is to see if that can help predict whether you will successfully come off the breathing machine.
Istanbul, IstanbulAges 18 years+
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Common questions
- Are there clinical trials for weaning?
- Yes. Clin2 currently lists 86 recruiting weaning studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a weaning trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a weaning trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.