Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06935864Recruiting
Study of KLF4 and KLF7 in bone tumors
This study looks at two proteins, KLF4 and KLF7, in bone tumor samples. It aims to understand their role in osteosarcoma and Ewing sarcoma, which may help develop better treatments.
CairoAges 1 month–39 years - NCT06936163Recruiting
Surgery for foot deformities in hereditary spastic paraplegia
This study looks at how well surgery works for foot problems like tight heel cords or clubfoot in people with hereditary spastic paraplegia (HSP), a condition that causes leg stiffness. It aims to see if surgery can improve walking, reduce pain, and prevent falls.
Shanghai, Shanghai MunicipalityAges 10–45 - NCT06937528RecruitingPhase 1
Extracellular vesicles for severe knee osteoarthritis
This trial tests whether tiny particles called extracellular vesicles can help treat severe knee osteoarthritis. If you have advanced knee arthritis and are otherwise healthy, you may be able to join.
AmmanAges 42–75 - NCT06937723Recruiting
App-based monitoring for spasticity in multiple sclerosis
This trial tests if a smartphone app can help monitor spasticity (muscle tightness or stiffness) in people with multiple sclerosis. If you have MS and spasticity that needs treatment, using your own smartphone might help track your health.
Düsseldorf, North Rhine-WestphaliaAges 18 years+ - NCT06938152RecruitingPhase 4
Comparing two bone-strengthening drug schedules for osteoporosis
This trial tests whether switching between two medications (Romosozumab and Denosumab) using a cycle or sequence schedule works better for improving bone density in postmenopausal women with severe osteoporosis. It aims to find the most effective treatment plan.
TaipeiAges 50–90 - NCT06939530Recruiting
Comparing shoulder stretch treatments for frozen shoulder
This study compares two different amounts of fluid injected into the shoulder joint to treat frozen shoulder (adhesive capsulitis). The goal is to see which volume works better for pain and movement.
CórdobaAges 30–70 - NCT06940479Recruiting
Testing a knee procedure for osteoarthritis pain relief
This trial studies changes in joint fluid before and after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. It aims to understand how the procedure works to reduce pain and improve knee function.
Aurora, ColoradoAges 18 years+ - NCT06941129RecruitingPhase 1
CAR T-cell therapy for resistant autoimmune diseases
This trial tests a new type of immune therapy called CAR T-cells that target two markers on your B cells (CD19 and BCMA). It is for people with certain autoimmune diseases that have not improved or have come back after standard treatments. The goal is to see if this therapy can help control the disease.
TianjinAges 18 years+ - NCT06940986Recruiting
Holistic pain self-management for military health system patients
This trial tests a holistic pain self-management program for people with long-term muscle or bone pain. It aims to help you take control of your pain through education and support, without relying only on medications.
Fairbanks, AlaskaAges 18 years+ - NCT06941584Recruiting
AIRE gene's role in autoimmune nerve diseases
This study looks at how the AIRE gene affects people with autoimmune nerve diseases like NMOSD, myasthenia gravis, and autoimmune encephalitis when they also have other autoimmune conditions. It may help researchers understand why some people get multiple autoimmune problems.
RomaAges 18 years+ - NCT06941636RecruitingPhase 3
Botox for jaw muscle pain from TMD
This trial tests whether Botox injections can reduce jaw and face muscle pain in people with temporomandibular disorders (TMD). It is for those who have had moderate to severe pain for at least 3 months and have not received Botox recently.
StockholmAges 18–50 - NCT06946199RecruitingPhase 1
Study of Cizutamig for Hard-to-Treat Rheumatoid Arthritis
This trial tests an experimental drug called cizutamig for people with rheumatoid arthritis that hasn't responded to other treatments. It aims to see if a new approach can help control the disease in patients who still have active inflammation despite trying other advanced therapies.
Wuhan, HubeiAges 18–75 - NCT06946316Recruiting
Dairy or plant drinks for stronger bones with exercise
This trial compares dairy and plant-based drinks to see which is better for bone health when you also do resistance training. If you are a postmenopausal woman or a man 50 or older, you may join to help find out which drink helps bones most.
Saskatoon, SaskatchewanAges Any age - NCT06946641RecruitingPhase 1
Testing QLS12010 safety in healthy adults and people with eczema
This trial tests a new drug, QLS12010, to see if it is safe and how it works in healthy volunteers and in people with moderate to severe atopic dermatitis (eczema). It may offer a new treatment option for those whose eczema has not improved with topical creams.
BeijingAges 18–75 - NCT06946940RecruitingPhase 2
Cannabis oil for fibromyalgia pain
This trial tests whether cannabis oil can help people with fibromyalgia who still have pain despite trying other treatments. Participants will receive cannabis oil, and researchers will look for biological markers that predict who responds best.
HaifaAges 30 years+ - NCT06947213Recruiting
Orthorexia nervosa in women with postmenopausal osteoporosis
This study looks at whether women with osteoporosis after menopause have a higher risk of orthorexia nervosa, an unhealthy obsession with healthy eating. It aims to compare women with and without osteoporosis to understand the connection.
IstanbulAges 55–75 - NCT06947746Recruiting
Studying stem cells for rheumatoid arthritis knee pain
This trial tests if stem cells can improve pain and swelling in the knee for people with rheumatoid arthritis that hasn't responded well to standard treatments. It's for those who still have significant knee symptoms despite taking medications.
ShanghaiAges 18–65 - NCT06948500Recruiting
Virtual reality exercise program for fibromyalgia pain
This study tests whether a virtual reality exercise program that changes how you see your own movements can help reduce pain and improve function in people with fibromyalgia. You would do the exercises at home using a headset, and researchers will check if this approach works better than standard exercise.
Valencia, Valencia-valènciaAges 18–80 - NCT06948903Recruiting
Fibromyalgia, brain sensitivity and thinking
This study looks at how the brain's pain sensitivity (central sensitization) relates to memory and thinking problems in people with fibromyalgia. Participating could help doctors understand and treat these symptoms better.
Istanbul, UskudarAges 18–65 - NCT06950463Recruiting
Circuit training for bone health after menopause
This trial tests whether a specific exercise program (circuit training) can improve bone density in women after menopause who have low bone mass. It may help strengthen bones and reduce fracture risk.
CairoAges 50–60 - NCT06950853Recruiting
Spinal surgery study using endoscopy to avoid fusion
This trial tests a less invasive spinal surgery using an endoscope (a small camera) to treat certain spine problems without fusing bones together, which may help you recover faster. It is for adults with specific types of back or leg pain from conditions like a failed previous fusion, a slipped vertebra, or a curved spine with narrowing.
BordeauxAges 18 years+ - NCT06952413RecruitingPhase 2
Rituximab for chronic fatigue syndrome (ME/CFS) trial
This trial tests if rituximab, a drug that affects the immune system, can help people with ME/CFS. You'll receive the drug in the hospital and be monitored for safety and improvement.
Kodaira, TokyoAges 18–65 - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT06956027Recruiting
Ultrasound study of Dupuytren's disease nodules
This study uses ultrasound to look at Dupuytren's disease nodules and track changes over 6 months. It may help doctors understand which nodules are active and need treatment.
Leuven, Vlaams-BrabantAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.