Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT02890485Recruiting
Dry needling for knee pain with stair or squat pain
This study tests whether dry needling can reduce ongoing knee pain in people who feel pain around the kneecap when going up or down stairs, squatting, or running. You may be able to join if your knee pain has lasted at least 3 months and you’re referred to physical therapy.
Columbus, OhioAges 18–40 - NCT02150850Recruiting
Registry for atypical femur fractures in adults 45+
This registry follows people in Quebec who have had an atypical femur fracture (a specific type of thigh-bone fracture). It aims to better understand these injuries and support future care by collecting health information over time.
Montreal, QuebecAges 45 years+ - NCT02842424RecruitingPhase 4
Ramipril for walking pain from blocked leg arteries
This study tests whether ramipril (a blood-pressure medicine) can improve leg muscle problems linked to poor blood flow in people with chronic claudication—pain that limits walking. It’s mainly looking at changes related to oxidative stress and muscle scarring (fibrosis).
Omaha, NebraskaAges 18–90 - NCT02355301Recruiting
Improve care for people with orthopedic (muscle or bone) problems
This trial aims to improve the quality of care for people with orthopedic problems, such as issues affecting muscles, bones, or joints. It may help by testing a way of delivering care more effectively.
BrusselsAges 1–90 - NCT02719314Recruiting
Study bone loss from steroid use in people with inflammatory disease
This study looks at how steroid medicines (called glucocorticoids) affect bone strength in people with long-term inflammatory rheumatic conditions or psoriasis. It may help improve how doctors check and manage osteoporosis risk and bone metabolism over time.
BerlinAges 18 years+ - NCT02836262Recruiting
New hip replacement implant for painful worn-out hip joints
This trial studies a specific hip replacement implant system in people whose hip pain is from worn-out (non-inflammatory) joint disease like osteoarthritis. It compares outcomes by tracking pain and function before and after surgery, and you must be able to return for follow-up visits.
Winnipeg, ManitobaAges 65–79 - NCT02329093Recruiting
Hip osteoarthritis with pain, testing non-weight bearing
This study looks at whether reducing weight on the hip can help slow how hip arthritis shows up on X-rays in people who have hip joint pain. It may be an option if your pain is from hip arthritis rather than a clear fracture.
Matsumoto, NaganoAges Any age - NCT02423395RecruitingPhase 3
Orphenadrine for muscle cramps in people with cirrhosis
This trial tests whether orphenadrine (a medication used to reduce muscle cramping) can lessen muscle cramps in people who have cirrhosis of the liver. It may help if your cramps happen often, but you must avoid certain medication conflicts and health situations.
TantaAges Any age - NCT02880891Recruiting
Splinting vs not splinting dental crowns on implants
This trial compares two ways of connecting single dental crowns (splinted vs not splinted) on dental implants. It looks at how well the gums and bone stay stable around the implants over time, after the crowns are put in.
Beijing, Beijing MunicipalityAges 20 years+ - NCT02504879Recruiting
Study of melorheostosis progression and genetic causes
This study follows adults with suspected or confirmed melorheostosis to understand how the condition develops and what outcomes to expect. It may help researchers better understand the disease and its genetic factors.
Bethesda, MarylandAges 18–90 - NCT02193841RecruitingPhase 3
Treating simple bone cysts in children with new bone support
This study looks at how well a treatment works for children with a simple bone cyst in an arm or leg. The goal is to prevent problems like fractures while the cyst heals, using a stabilizing implant in the bone.
Birmingham, AlabamaAges 2–21 - NCT02196155Recruiting
Botox or steroid shots for long-term heel pain
This trial compares botulinum toxin A (“Botox”) to steroid injections for chronic plantar fasciitis, a common cause of heel and foot pain. It aims to see which shot helps symptoms better when other treatments haven’t worked for at least 3 months.
BernAges 18–60 - NCT02814149Recruiting
Compare early vs delayed dental implant placement
This trial studies whether placing a dental implant right away or after a delay leads to better appearance and healing. It looks at cosmetic results and X-ray findings, and is for people missing one front upper tooth.
Guangzhou, GuangdongAges 18–80 - NCT02589106Recruiting
Brace study for teens with early scoliosis
This trial tests a special type of brace made with “anisotropic textile” material for adolescents with a specific kind of side-bending spine problem called adolescent idiopathic scoliosis (AIS). It may help by improving curve measurements while you follow a structured brace plan.
Hong Kong, GuangdongAges 10–14 - NCT02356497Recruiting
Study of treatments for bone metastases using routine data
This study follows adults with cancer that has spread to the bones and who are receiving radiation treatment. It looks at how interventional (procedure-based) treatment decisions affect outcomes by using information collected during routine care.
Utrecht, UtrechtAges 18 years+ - NCT02257229Recruiting
Study for treating clubfoot in Spanish-speaking patients
This study looks at treatment for children with clubfoot (a foot that turns inward or upward). If you speak Spanish, the study may be easier to join and could help doctors improve how clubfoot is treated.
Dallas, TexasAges Up to 18 years - NCT02230826Recruiting
Follow-up study of long-term outcomes after hip replacement
This is an observation (not experimental) study that follows adults who receive a Corin hip replacement to see how well they do long-term. It may help doctors understand which patients benefit most and how hip implants perform over time.
BordeauxAges 18 years+ - NCT02844738RecruitingPhase 2
Cell therapy for shoulder osteoarthritis pain and inflammation
This trial tests a treatment using your own (autologous) regenerative cells to reduce pain and inflammation from shoulder osteoarthritis. It may help people with long-lasting shoulder pain, but you must meet several health and medication timing requirements.
Grove City, PennsylvaniaAges 18–90 - NCT02844764RecruitingPhase 2
Cell therapy test for hip osteoarthritis pain and swelling
This trial tests an “autologous” regenerative cell treatment, meaning cells taken from you, to reduce hip osteoarthritis pain and inflammation. It checks safety first and looks for improvements in how you feel and move.
Grove City, PennsylvaniaAges 18–90 - NCT02844751RecruitingPhase 2
Regenerative knee cell therapy for arthritis pain and swelling
This Phase 2 study tests a patient’s own (autologous) regenerative cell treatment to reduce knee pain and inflammation from osteoarthritis. It mainly looks at whether the treatment is safe and whether it can improve symptoms over time.
Grove City, PennsylvaniaAges 18–90 - NCT02769975Recruiting
Check children and teens with hormone and metabolism problems
This study evaluates children (and sometimes relatives) who may have hormone (endocrine) or metabolism-related conditions. It helps doctors better understand these problems by doing a clinical evaluation.
Bethesda, MarylandAges 3 months–100 years - NCT02257723Recruiting
Testing combined Korean herbal and therapy for hospitalized spine or joint pain
This trial studies whether a combined complementary treatment approach helps people who are hospitalized for spine or joint problems. It may help reduce the types of pain that come from those areas.
Seoul, Gangnam-GuAges Any age - NCT02283996RecruitingPhase 4
Compare physical therapy for frozen shoulder
This study looks at how well physical therapy works for “frozen shoulder” and also compares the practical cost impact. It will randomly assign you to one of the study groups to see which approach helps most.
Boston, MassachusettsAges 18 years+ - NCT02597881Recruiting
Study of achondroplasia health changes over time
This study follows people with achondroplasia to better understand what medical issues happen over time. It may help doctors plan care and recognize patterns earlier.
Baltimore, MarylandAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.