Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT01353430Recruiting
Study of a rare muscle condition linked to Paget bone disease
This study looks at people and families with a rare muscle weakness condition that can be linked with Paget disease of the bone (and sometimes frontotemporal dementia). It aims to better describe how these conditions appear and relate, which can help future research and care.
Irvine, CaliforniaAges 18 years+ - NCT00912041Recruiting
Test of a brain-to-computer device for quadriplegia
This study tests whether a tiny brain computer interface can help people with quadriplegia (loss of movement in all four limbs) communicate or control technology. It’s mainly a feasibility study, meaning the goal is to see if the device can work safely and reliably in real life.
Sacramento, CaliforniaAges 18–80 - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT01484678Recruiting
MRI and body biomarkers study for muscular dystrophy
This study uses MRI scans and blood or other biomarkers to better understand muscular dystrophy in people with Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). It may help researchers track disease changes and identify measurable markers over time.
Gainesville, FloridaAges 5–62 - NCT00874783Recruiting
Testing nerve-cell growth from donated body cells
This trial uses donated body cells or small hair samples from people with neurological diseases (and healthy donors) to try to grow “nerve-like” cells for research. It may help scientists learn how to better study and treat different neurological conditions.
Jerusalem, IsraelAges 18 years+ - NCT00748254Recruiting
Laser imaging test for rheumatoid arthritis inflammation
This study uses a laser-based imaging method to “see” inflammation in people with rheumatoid arthritis. It may help researchers better understand how active joint inflammation looks and how it changes.
Ann Arbor, MichiganAges 18 years+ - NCT01166854Recruiting
Study of muscle and bone conditions in families
This study looks at how certain muscle and bone diseases show up in people and in their family members. It may help researchers better describe these conditions and improve future diagnosis and care.
Irvine, CaliforniaAges 18 years+ - NCT01581294Recruiting
Norwegian arthritis drug registry for new biologic or kinase treatment
This study is a real-world registry that follows adults with inflammatory arthritis when they start a new targeted medicine. It helps researchers understand how these drugs work in everyday care.
Drammen, BuskerudAges 18 years+ - NCT00932594Recruiting
New treatment approach for jaw joint problems
This trial studies a “serial” (step-by-step) treatment plan for temporomandibular disorders (TMJ), which can cause pain, clicking, and trouble opening your mouth. It may help by improving how your jaw joint moves and reducing symptoms.
Guangzhou, GuangdongAges 16–60 - NCT01276470Recruiting
Study of environmental triggers in anti-synthetase syndrome
This study looks for environmental risk factors that may be linked to anti-synthetase syndrome, a type of inflammatory muscle disease. It compares people with the condition to carefully matched people without it, using questionnaires, blood samples, and lung imaging when needed.
Miami, FloridaAges 2–100 - NCT01668186Recruiting
Study of how peroxisome disorders change over time
This study follows people with peroxisome biogenesis disorders (PBD) or closely related enzyme/protein defects to learn how symptoms and health changes over time. It may help researchers better understand the condition and plan future treatments.
Montreal, QuebecAges Any age - NCT01706692Recruiting
Study registry for targeted treatments in psoriasis patients
This trial is a registry that collects information from adults with plaque psoriasis or psoriatic arthritis who are starting a new biologic or other systemic treatment. It helps researchers understand how these treatments are used in real life and what outcomes they may have.
AarauAges 18 years+ - NCT02362685Recruiting
Metabolic exercise testing study
This study is about doing a breathing-and-heart performance test while you exercise to better understand how your body uses energy. You may join if you’re referred for this type of test and can safely complete it.
BrestAges 5 years+ - NCT02432625Recruiting
Long-term study of bone fragility in osteogenesis imperfecta
This study follows people with osteogenesis imperfecta (OI) to better understand how it affects bones and related issues over time. It may help doctors learn which features and genetic changes predict problems, and guide future care.
Phoenix, ArizonaAges Any age - NCT02399527Recruiting
Lymphatic problem registry for tracking outcomes
This study enrolls people with certain lymphatic (lymph fluid) conditions to collect information and track how they do over time. It may help doctors better understand outcomes and improve care.
Boston, MassachusettsAges Any age - NCT02434003Recruiting
Test a new way to predict scoliosis curve progression
This study follows adolescents with idiopathic scoliosis to see how well a new predictive model estimates whether the spinal curve will get worse over time. It may help doctors plan monitoring and treatment more accurately for young people with scoliosis.
San Diego, CaliforniaAges 10–15 - NCT02635022Recruiting
Care plan plus bone-medicine monitoring after a fracture
This study tests a structured care service to help people manage osteoporosis after a new bone fragility fracture. It aims to improve how you take bone-protecting medicines and to make sure treatment is followed and monitored over time.
HsinchuAges 50 years+ - NCT02103361Recruiting
Pregnancy registry for Stelara or Tremfya exposure
This study is a pregnancy exposure registry. It collects information to better understand pregnancy outcomes after exposure to Stelara or Tremfya (medicines used for autoimmune diseases).
La Jolla, CaliforniaAges Any age - NCT02913352Recruiting
Surgery comparison for repeat shoulder dislocation
This trial compares two surgical techniques to stop the shoulder from repeatedly dislocating when there is significant damage to the shoulder socket and “matching” damage to the ball. It may help you if past repair hasn’t worked and imaging shows you have a higher-risk pattern of instability.
São Paulo, São PauloAges 16 years+ - NCT02143986Recruiting
Testing glycosylated ferritin to evaluate inflammation
This trial looks at a blood test called “glycosylated ferritin” to help doctors better identify certain dangerous inflammatory conditions. It may help clarify whether your high iron-related marker is due to inflammation rather than other causes.
BrusselsAges Up to 85 years - NCT02774746Recruiting
Study of delivery outcomes in babies with gastroschisis
This study follows pregnancies and newborn outcomes for babies diagnosed with gastroschisis (an opening in the baby’s belly present before birth). It aims to understand what delivery and early care lead to better outcomes for these babies.
Phoenix, ArizonaAges 18 years+ - NCT02418442Recruiting
Kid rheumatic disease registry study for follow-up care
This is an observational study that follows children and teens with rheumatic (joint/inflammatory) diseases to better understand how they develop and are cared for over time. You may help by letting the study contact your family in the future and by completing study tasks as needed.
Birmingham, AlabamaAges Up to 21 years - NCT02435940Recruiting
Registry for inherited eye vision conditions
This study is a registry, meaning it collects information about people with inherited retinal (retina) diseases. It may help researchers learn how these conditions progress and connect you with future studies or treatments.
Columbia, MarylandAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.