Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT02677961Recruiting
Build a bone and soft tissue tumor health record registry
This registry collects health information from people with bone or soft tissue tumors to help researchers understand these cancers better. You may be able to join if you (or your legal decision-maker) can consent to participate.
Columbus, OhioAges 18 years+ - NCT02771496Recruiting
Study of knee cartilage injury diagnosis using imaging
This study looks at people with a specific knee cartilage problem called osteochondritis dissecans (or a focal cartilage defect). It uses X-rays or MRI scans to confirm the diagnosis, which helps researchers understand the condition and how it’s identified.
Philadelphia, PennsylvaniaAges Any age - NCT02327884Recruiting
Study saliva and related diseases to learn health patterns
This study looks at diseases that involve the salivary (saliva) glands, and may also include people with active hepatitis, oral cancer, or healthy adults. Researchers collect blood, urine, saliva, and sometimes tissue to better understand what’s happening and how these conditions relate to saliva and oral health.
Bethesda, MarylandAges 4–100 - NCT02745158Recruiting
FOP patient registry for people with confirmed diagnoses
This trial is a registry that collects information from people with fibrodysplasia ossificans progressiva (FOP). It helps researchers better understand the condition and use that knowledge for future studies that could lead to better care.
North Kansas City, MissouriAges Any age - NCT02398786Recruiting
Join a family registry for myotonic dystrophy (DM1 or DM2)
This study builds a registry of people and families affected by myotonic dystrophy types 1 and 2. It helps researchers learn about the condition over time and may support future studies that could lead to better care.
Oakland, CaliforniaAges Any age - NCT02748408Recruiting
Long-term follow-up after total hip replacement for severe hip pain
This study tracks people for many years after they get their first total hip replacement due to severe hip problems. It helps doctors understand how well the implant works and how patients recover over time.
ViennaAges 18–75 - NCT02469662Recruiting
Study of outcomes after Nexel total elbow replacement
This study looks at how well the Nexel total elbow replacement works over time for people who need an elbow replacement due to pain, damage, or instability. It may help the doctors understand which patients benefit most and what results to expect.
Golden, ColoradoAges 18 years+ - NCT02511158Recruiting
Knee ligament surgery study after ACL reconstruction
This study follows people who have a knee ligament tear and undergo surgery to rebuild the ligament. It may help doctors better understand recovery and outcomes after different surgical techniques.
ParisAges 7 years+ - NCT02639312Recruiting
Study of how craniofacial differences develop over time
This study follows children and adults with craniofacial (head/face) differences to learn how their growth changes over time. It also enrolls unaffected family members and healthy volunteers to compare what is “typical,” using scans and optional genetic testing.
Bethesda, MarylandAges 2–100 - NCT02661139Recruiting
Registry of jaw reconstruction for cancer patients who need implants
This study is a “real-world” registry that follows people with jaw problems related to cancer or cancer treatment. It looks at how well jaw reconstruction with dental implants and fixed teeth works when removable dentures are not suitable.
BrugesAges Any age - NCT02714634RecruitingPhase 4
Methotrexate or leflunomide plus added therapy for rheumatoid arthritis
This study compares two combination treatments for rheumatoid arthritis in people whose current methotrexate or leflunomide isn’t working well enough. It aims to see whether adding a targeted therapy works better than the standard add-on of sulfasalazine plus hydroxychloroquine.
StrasbourgAges 18 years+ - NCT02811523RecruitingPhase 1
Testing a lung procedure to treat sarcoma lung metastases
This early-phase study tests a special way to deliver medicine directly to the lungs (called IVLP) for sarcoma that has spread to both lungs. It aims to control lung metastases while reducing side effects, and it uses a plan that often includes surgery or focused radiation around the procedure.
TorontoAges birth–64 years - NCT02890641Recruiting
Study of brain signals and genes in hard-to-treat epilepsy
This study looks at genetic factors and brain electrical activity in children whose seizures are difficult to control with standard medicines. It also involves exams like MRI and possibly procedures under anesthesia, to better understand seizure causes and help future care.
ParisAges 3 months–25 years - NCT02915120Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial studies whether a targeted, ultrasound-guided “pulsed” radiofrequency treatment can reduce long-lasting knee pain from osteoarthritis. It may help if your knee pain is not improving with common medicines and injections.
Palma, Balear IslandsAges 40 years+ - NCT03155854Recruiting
Surgery to prevent scarring in trigger finger
This study looks at whether doing a limited surgery in advance can improve outcomes and reduce scarring for people with trigger finger who also have a specific palm cord condition. It may help you heal better if you’ve already tried non-surgical treatment or chose surgery.
Rochester, MinnesotaAges 18 years+ - NCT03332251Recruiting
Posture brace study for teens with early scoliosis
This trial tests whether a posture-correction “girdle” brace can help adolescents with early scoliosis. If you have a small curve and haven’t started treatment yet, it may help slow or improve the curve while you follow the brace plan.
Hong KongAges 10–13 - NCT03344484Recruiting
Compare two surgical approaches for degenerative low back slippage
This trial compares two different surgical approaches for degenerative spondylolisthesis (a “slipped” lower-back vertebra) to see which works better for pain and walking. You may be considered if you need surgery after months of non-surgical treatments.
Halifax, Nova ScotiaAges Any age - NCT02945345Recruiting
Test how skin scores change in cutaneous dermatomyositis
This study looks at how well skin symptoms improve in adults with cutaneous dermatomyositis by using a specific skin-scoring tool. The results may help doctors better measure treatment response and guide care.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03325946Recruiting
Neuromotor research clinic for people with movement problems
This study is looking at people who have difficulties with movement or muscle control (neuromotor impairment). It may help researchers better understand these problems and improve future care.
Roanoke, VirginiaAges 3 months–18 years - NCT02993029Recruiting
Fluoride scan–guided treatment for painful knee arthritis
This trial studies a targeted treatment using a fluoride-related injection to help reduce pain from knee osteoarthritis. To join, you need a painful osteoarthritis knee and a specific bone-scan finding (SUV above 10) on an imaging test.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT03320759Recruiting
Improving recovery after non-traumatic spinal cord injury
This study looks at ways to help people recover after spinal cord injury that was not caused by trauma. It may help by testing an approach that is guided by regular MRI scans and repeat therapy visits.
London, OntarioAges 18 years+ - NCT03042026Recruiting
Testing a simple system to recognize acromegaly
This study tests a simple recognition tool to help tell whether someone has acromegaly or not. It may be useful for faster, easier identification of the condition.
TaipeiAges 20–80 - NCT06201416RecruitingPhase 1
Single dose of SBT777101 for rheumatoid arthritis
This study tests a single dose of an experimental drug called SBT777101 for people with moderate to severe rheumatoid arthritis who have already tried and failed at least two advanced treatments. The goal is to see if it is safe and how the body handles it.
Scottsdale, ArizonaAges 18–70 - NCT07677033Recruiting
Bone and muscle health study for adults
This study looks at how well your bones and muscles work together. By measuring your bone density and handgrip strength, doctors can better understand your bone health and find ways to keep you strong as you age.
Küçükçekmece, IstanbulAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.