Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07361107RecruitingPhase 1
Immune response study of histotripsy in colorectal cancer
This trial tests how your body's immune system reacts to a treatment called histotripsy for colorectal cancer that has spread to the liver. Histotripsy uses sound waves to break apart tumors, and the study aims to see if this can help your immune system fight the cancer better.
New Hyde Park, New YorkAges 18 years+ - NCT07352995Enrolling by invitation
Gut temperature study during colonoscopy
This study uses a special probe to measure temperature inside the colon during a routine colonoscopy. It may help researchers understand conditions like IBD, Crohn's disease, and ulcerative colitis.
Boston, MassachusettsAges 18 years+ - NCT07353684RecruitingPhase 2
Adebrelimab plus apatinib with chemo for gastric cancer
This trial tests a combination of two targeted drugs (adebrelimab and apatinib) with standard chemotherapy (SOX regimen) before surgery for gastric cancer that cannot be removed right away. The goal is to shrink the tumor enough to make surgery possible.
Beijing, Beijing MunicipalityAges 18–75 - NCT07354295Recruiting
Using AI to predict treatment response in esophageal cancer
This trial uses a combination of imaging and clinical data to see if a computer model can predict how well your treatment will work. It aims to help doctors better understand your cancer risk and choose the best treatment plan for you.
Wuhan, Other (Non U.s.)Ages Any age - NCT07360938Recruiting
How inflammation affects drug processing
This study looks at how inflammation from conditions like diabetes, IBD, or kidney disease affects the way drugs work in the body. It may help improve dosing and safety for patients with these conditions.
Indianapolis, IndianaAges 12–99 - NCT07358234Enrolling by invitationEarly Phase 1
Comparing two EoE treatments on esophagus widening
This study compares two medicines—Eohilia (an oral steroid) and Dupixent (an injectable biologic)—to see which one better helps widen the esophagus in people with eosinophilic esophagitis (EoE). It may help you if you have active EoE and are looking for a new treatment option.
Scottsdale, ArizonaAges 18 years+ - NCT07360119Recruiting
Pancreas removal with islet transplant for high-risk tumors
This trial removes the whole pancreas in people with certain pancreatic tumors and then transplants the patient's own insulin-making cells (islets) into the liver. The goal is to prevent or reduce diabetes after surgery.
Baltimore, MarylandAges 18 years+ - NCT07355777Recruiting
Video tutorial for first colonoscopy preparation
This trial tests whether adding a short video tutorial to the usual verbal instructions helps people prepare better for their first colonoscopy. It aims to see if the video makes the preparation process easier and more effective.
LyonAges 18–80 - NCT07359742Recruiting
Detecting liver scarring in chronic liver disease
This trial looks for better ways to detect liver scarring (fibrosis) in people with long-term liver disease. It may help find problems earlier.
BrusselsAges 18 years+ - NCT07353853Recruiting
Pre-packaged low-residue diet for colonoscopy prep in IBD
This trial tests if a special pre-packaged low-residue diet can improve bowel preparation for colonoscopy in people with inflammatory bowel disease (IBD). It aims to make the prep easier and more effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07359586Recruiting
Laryngopharyngeal injury after breathing tube under anesthesia
This study looks at throat and voice box injuries that can happen after having a breathing tube during surgery. It may help doctors understand why some people experience hoarseness, sore throat, cough, or choking after non-ear-nose-throat operations.
Hangzhou, ZhejiangAges Any age - NCT06849180Recruiting
Personalized Treatment for Advanced Combined Liver Cancer
This study is for people with a rare and advanced liver cancer called combined hepatocellular cholangiocarcinoma (CHC). Doctors will use information from your tumor and health history to find the best treatment approach for your specific cancer type.
Nanjing, JiangsuAges 18 years+ - NCT06850454RecruitingPhase 3
Olanzapine vs placebo for nausea from first chemo
This study tests if the drug olanzapine (commonly used for nausea) can help prevent vomiting in people receiving moderately strong chemotherapy for the first time. It may be a good fit if you're about to start treatment with oxaliplatin, irinotecan, or carboplatin and haven't had severe nausea treatments before.
Bangkok, BangkokAges 18 years+ - NCT06850480RecruitingPhase 3
Study of JP-1366 tablets for heartburn and acid reflux
This trial tests a new medication, JP-1366, for people with reflux esophagitis (damage to the esophagus from stomach acid). It aims to see if the drug is safe and effective at healing the esophagus and relieving symptoms like heartburn and regurgitation.
Beijing, Beijing MunicipalityAges 18–75 - NCT02634645Recruiting
Treatment study for Barrett’s pre-cancer or esophageal cancer
This study looks at treatment options for people with Barrett’s esophagus that has progressed to abnormal cell growth (dysplasia) or cancer. It may help doctors compare approaches that use procedures to remove and/or destroy abnormal tissue in the esophagus.
Los Angeles, CaliforniaAges 18–100 - NCT04147078RecruitingPhase 1
Personalized immune vaccine after surgery for certain cancers
This Phase 1 study tests a personalized vaccine made for you to help your immune system after you’ve had surgery or ablation for certain cancers. It’s mainly done to check safety and see how well the vaccine can work at preventing cancer from coming back.
Chengdu, SichuanAges 18–100 - NCT06344156RecruitingPhase 1
Personalized vaccine combined with immunotherapy and chemo after pancreatic cancer surgery
This trial tests a personalized neoantigen vaccine given along with an anti-PD1 drug (pembrolizumab) and chemotherapy after surgery for pancreatic cancer. The goal is to see if this combination can help prevent the cancer from coming back.
Chengdu, SichuanAges 18–75 - NCT06463366Recruiting
Using MRI to better diagnose liver fat, inflammation, and scarring
This study uses advanced MRI scans to get a clearer picture of liver fat, inflammation, and scarring in people with chronic liver disease. It aims to help doctors diagnose and understand liver problems better.
Shenyang, LiaoningAges 18–75 - NCT06758024Recruiting
Optimizing infliximab for inflammatory bowel disease
This trial tests whether closely monitoring and adjusting infliximab (a biologic medicine) can help people hospitalized with a moderate-to-severe flare of Crohn's disease, ulcerative colitis, or unclassified inflammatory bowel disease who haven't gotten better with IV steroids. The goal is to improve treatment response and outcomes.
SantiagoAges 18–75 - NCT06852287RecruitingPhase 2
Study of chemo, targeted therapy, and immunotherapy for bile duct and gallbladder cancer
This trial tests a combination of chemotherapy directly to the liver, a targeted therapy pill, and an immunotherapy drug for people with advanced bile duct or gallbladder cancer that cannot be surgically removed. The goal is to see if this triple therapy can shrink or control the cancer.
Tianjin, TiaAges 18 years+ - NCT04331639Recruiting
High-dose vitamin D for kids with IBD on biologic therapy
This trial studies whether giving a higher dose of vitamin D3 helps children and teens with inflammatory bowel disease (Crohn’s or ulcerative colitis) who have low vitamin D levels. Participants are already on biologic medicines and will be treated while monitoring blood (and safety) related to vitamin D.
Boston, MassachusettsAges 5–25 - NCT06855485Recruiting
Stent for pancreatic pseudocyst drainage study
This trial tests a new stent device (HANAROSTEN® HOT Plumber™ with Z-EUSIT™) to drain fluid collections in the pancreas. It may help if you have a pancreatic pseudocyst or walled-off necrosis with mostly fluid content.
Seoul, SeoulAges 18 years+ - NCT06854679Recruiting
MRI-guided radiation for rectal cancer
This trial tests a new way of giving radiation therapy for rectal cancer, using MRI scans to aim the radiation more precisely. It's for people who need chemotherapy and radiation before surgery, and it aims to make treatment more effective while reducing side effects.
Sutton, SurreyAges 18 years+ - NCT06853756Recruiting
Comparing two airway devices in children having orthopedic surgery
This trial compares two types of breathing tubes (I-gel and Ambu AuraGain) used during anesthesia to see which one causes less air to enter the stomach. It is for children ages 2-12 having planned orthopedic surgery.
Tanta, El-GharbiaAges 2–12
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.