Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06305949Recruiting
Brain stimulation to improve swallowing after stroke
This trial tests a gentle electrical brain stimulation (tDCS) to see if it helps improve swallowing after a first-time stroke. It is designed for people who are at least 3 weeks post-stroke and still have swallowing problems.
Bucheon-siAges 19 years+ - NCT06306755Recruiting
Risk-based screening for esophageal and gastric cancer
This study tests a new way of screening for esophagus and stomach cancer by using a risk-based approach. It aims to see if this works better than standard screening, and is offered to people in certain villages in China.
Beijing, Beijing MunicipalityAges 50–69 - NCT06306196RecruitingPhase 2
Hepatitis E vaccine study in healthy adults, children, and people with HIV
This study tests a hepatitis E vaccine called Hecolin in healthy people (ages 2–45) and in adults (18–45) living with HIV who are on antiviral treatment. It aims to see how well the vaccine works and if it's safe for different groups.
Ga-RankuwaAges 2–45 - NCT06307080Recruiting
Combined ablation and immunotherapy for pancreatic cancer with liver spread
This study tests a new treatment combining tumor destruction with heat/cold (ablation) and an immunotherapy drug (PD-1) for people whose pancreatic cancer has spread to the liver. The goal is to help the immune system fight the cancer better.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06306963Recruiting
Stomach blood vessel condition and digestion symptoms study
This study looks at people with a stomach condition called gastric antral vascular ectasia (GAVE) to understand how it affects digestion and causes symptoms. Researchers want to learn if stomach muscle function problems are common in this condition.
Rochester, MinnesotaAges 19 years+ - NCT06307249RecruitingPhase 1
Precision therapy for solid tumors targeting CDK4/6 and VEGF
This trial tests a combination of two targeted drugs for advanced solid tumors like colorectal, lung, breast, and genitourinary cancers. The goal is to see if blocking certain proteins and a long RNA molecule can slow tumor growth.
Tripoli, North LebanonAges 18 years+ - NCT06307548RecruitingPhase 1/Phase 2
Image-guided surgery and light therapy for colorectal cancer
This trial tests a special dye that helps surgeons see tumors more clearly during surgery, followed by a light therapy to destroy any remaining cancer cells. It is for people with advanced or returning colorectal cancer who are already scheduled for surgery.
Buffalo, New YorkAges 18 years+ - NCT06307925RecruitingPhase 1
HC010 for advanced solid tumors: a safety and early efficacy study
This trial is testing a new drug (HC010) for people with advanced solid tumors that have not responded to standard treatments. It aims to see if the drug is safe, how it works in the body, and whether it can shrink tumors.
Guangzhou, GuangdongAges 18–75 - NCT06307964Recruiting
Gut bacteria in alcoholic hepatitis
This trial is looking at bacteria inside the liver of people with alcoholic hepatitis. It may help understand how these bacteria affect the disease and lead to better treatments.
LyonAges 18 years+ - NCT06307938Recruiting
Liquid biopsy test for colorectal cancer before colonoscopy
This trial tests a simple blood test (liquid biopsy) to find cancer signals in the DNA of people being called for a colonoscopy. If you are scheduled for a colonoscopy, your blood sample could help doctors detect colorectal cancer earlier and plan better treatment.
LevangerAges 18 years+ - NCT06308510Recruiting
Improving stomach cancer detection with a fluid test
This study tests whether looking for certain DNA changes in the fluid from your belly can help doctors find stomach cancer that has spread. The goal is to make standard tests more accurate so treatment can be better planned.
RotterdamAges 18 years+ - NCT06308757Recruiting
Studying a very low calorie keto diet for fatty liver disease with scarring
This trial tests whether a very low calorie ketogenic diet (a strict low-carb, high-fat diet) can help people with non-alcoholic steatohepatitis (NASH) who have liver scarring. Participants will follow this diet for a year and have two liver biopsies to see if their liver health improves.
BolognaAges 18 years+ - NCT06309017Recruiting
Nutrition before bowel surgery for IBD patients
This trial tests whether a special nutrition drink taken before surgery can help people with inflammatory bowel disease (IBD) recover better after bowel surgery. It is for adults with IBD who are already scheduled for surgery at NYU Langone Health.
New York, New YorkAges 18 years+ - NCT06309199Recruiting
Healthy Baby Digestive Health and Probiotics Study
This study looks at how common digestive problems are in healthy babies and whether probiotics can help. It involves following your baby from birth to age 1 with regular check-ups.
Bangkok, BangkokAges 3 days–1 year - NCT06309602Recruiting
Testing a free water protocol for stroke or trauma patients
This trial studies whether allowing patients who are on thickened liquids to also have sips of plain water is safe. It may help people who are recovering from stroke or injury and can protect their own airway.
Loveland, ColoradoAges 18 years+ - NCT06310291RecruitingEarly Phase 1
VTP-1000 vaccine for adults with celiac disease
This trial tests an experimental vaccine called VTP-1000 in adults with celiac disease. It may help calm the immune system so that accidentally eating gluten causes fewer or less severe symptoms.
Los Angeles, CaliforniaAges 18–70 - NCT06310564Recruiting
SBRT for limited metastatic colorectal cancer
This trial tests whether focused radiation (SBRT) can treat 1 to 3 metastases in people with colorectal cancer that has spread but is still low or intermediate risk. It may be an option if you are starting first or second line systemic therapy and your primary tumor is under control.
Negrar, VeronaAges 18 years+ - NCT06310902Recruiting
Single-cell study for resectable pancreatic cancer patients
This trial uses a special technique called single-cell sequencing to study pancreatic cancer cells from patients whose tumors can be surgically removed or are on the edge of being removable. Participation may help researchers understand the disease better and could guide future treatments.
Fuzhou, FujianAges 18–75 - NCT06311110Recruiting
Toilet training and bladder issues in children with DCD
This study looks at how Developmental Coordination Disorder (DCD) affects toilet training, bladder, and bowel function in children. It compares children with DCD to those with typical development to identify differences and problems.
Ghent, East FlandersAges 5–8 - NCT06311123Recruiting
Study of Ozanimod's Effects on Immune Cells in Ulcerative Colitis
This study looks at how the medicine ozanimod works in people with active ulcerative colitis. Researchers will use a special blood test to understand how the drug affects your immune system.
San Diego, CaliforniaAges 18 years+ - NCT06313190RecruitingPhase 2
SBRT plus immunotherapy for small liver cancer
This trial tests a combination of targeted radiation (SBRT) and immunotherapy for people with small liver cancers that have come back or are still present after prior treatment. It aims to see if this approach can better control the cancer without using heavy chemotherapy.
Guangzhou, GuangdongAges 18–75 - NCT06313567RecruitingPhase 3
Metronomic capecitabine for stage III stomach cancer
This trial tests a low-dose, frequent regimen of the chemotherapy drug capecitabine (taken as a pill) to see if it can help prevent stage III stomach cancer from coming back after surgery. It's for people who have had their stomach cancer completely removed with a specific type of lymph node dissection.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06313801RecruitingPhase 2
Chemotherapy with or without PIPAC for stomach cancer
This trial tests whether adding a special type of chemotherapy sprayed directly into the abdomen (PIPAC) to standard chemotherapy is safer and works better for stomach cancer that has spread only to the lining of the abdomen.
Nizhny NovgorodAges 18–75 - NCT06313827Recruiting
Online program to prevent flare-ups in cystic fibrosis
This trial tests an online program designed to help people with cystic fibrosis avoid exacerbations (sudden worsening of symptoms). You participate from home using a device with internet, camera, and microphone.
ValenciaAges 6 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.