Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06314022Recruiting
Mobile app for better colonoscopy in cancer screening
This study tests a mobile app designed to help improve the quality of colonoscopies for people in a colorectal cancer screening program. If you have had a positive FIT test and are between 50 and 69, you may be able to join.
Valladolid, ValladolidAges 50–74 - NCT06314646Recruiting
Comparing two ways to reconnect the intestine after rectal cancer surgery
This study compares two ways of reconnecting the intestine after rectal cancer surgery. It looks at a newer method called TTSS against the standard double-stapled technique.
Rozzano, MIAges 18 years+ - NCT06315179Recruiting
Spatial gene study for inflammatory bowel disease
This study looks at tissue samples from people with suspected Crohn's disease, ulcerative colitis, or indeterminate colitis. The goal is to understand these conditions better and may lead to improved treatments.
Seattle, WashingtonAges 6–21 - NCT06315738RecruitingPhase 1/Phase 2
Testing ST266 in Babies with NEC
This study tests an investigational drug called ST266 in babies with necrotizing enterocolitis (NEC), a serious gut infection. The goal is to see if it is safe and can help heal the bowel.
Little Rock, ArkansasAges 2 weeks–2 months - NCT06316154Recruiting
Liver cyst wall study during echinococcosis surgery
This study looks at parts of the liver cyst wall during surgery for echinococcosis. It aims to learn more about the infection to help future treatments.
Tashkent, UzbekistanAges 18–80 - NCT06317181Recruiting
Liver disease evaluation with AI-enhanced ultrasound
This trial tests whether a new deep-learning computer program can better detect liver disease using ultrasound data. It may help improve diagnosis without extra procedures.
DresdenAges 18 years+ - NCT06317441Recruiting
Probiotic for bloating and high hydrogen breath test
This study tests a probiotic pill for people with bothersome bloating and an abnormal hydrogen breath test. It aims to see if the probiotic helps improve gut symptoms.
Calgary, AlbertaAges 18–65 - NCT06319755Recruiting
Gut bacteria after Whipple surgery
This study looks at gut bacteria in people who had Whipple surgery for pancreatic cancer and in healthy volunteers. It aims to understand how the microbiome changes after surgery.
Camperdown, New South WalesAges 18 years+ - NCT06320990RecruitingPhase 1
Tamoxifen to prevent cancer in pancreatic cysts
This trial tests whether tamoxifen, a hormone-blocking pill, can prevent pancreatic cysts from turning into cancer in people who are not having surgery to remove the cyst right away.
Omaha, NebraskaAges 19 years+ - NCT06322680Recruiting
Drain tubes to prevent pancreas leak after Whipple surgery
This trial is testing whether draining the main pancreatic and bile ducts during a Whipple procedure can lower the risk of a pancreatic leak. The study focuses on people with a higher chance of this complication.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06323681Recruiting
Lower-dose interferon for chronic hepatitis B patients who've tried it before
This study tests a lower dose of pegylated interferon for people with chronic hepatitis B whose virus levels dropped significantly during a previous interferon treatment. It aims to see if a second round can further reduce or clear the virus.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06324539Recruiting
New method to detect celiac disease markers during endoscopy
This trial tests a new way to find specific markers for celiac disease during a routine endoscopy. It may help people who are getting an endoscopy to check for celiac or other digestive conditions.
NaplesAges 2–17 - NCT06325982Recruiting
Preventing rectal injury from radiation with a medicated enema
This trial tests whether a medicated enema can help prevent radiation damage to the rectum during pelvic radiotherapy. It may be a good option if you are starting radiation to the pelvis or rectum and are otherwise in good health.
Xiamen, FujianAges Any age - NCT05679622Recruiting
Stool transplant study for children with mild to moderate ulcerative colitis
This trial studies whether transferring healthy stool bacteria into the gut (fecal microbiota transplantation, or FMT) can improve symptoms in children with ulcerative colitis. It may help by changing gut bacteria, especially for children who are newly diagnosed or who didn’t respond to standard treatments.
WuhanAges 2–16 - NCT05181826Recruiting
Blood collection study for cancer and benign diseases
This study collects blood samples from people with different health conditions (cancer, diabetes, liver disease, etc.) and from healthy volunteers. The goal is to find markers in the blood that could help detect or monitor diseases.
Redondo Beach, CaliforniaAges 18 years+ - NCT05199259Recruiting
Blood test study for people at risk for or with liver cancer
This trial tests a new blood test to help detect liver cancer (HCC) or confirm it’s not present in people with cirrhosis who are being monitored. It may help improve how doctors screen for liver cancer and decide who needs further imaging or treatment.
Escondido, CaliforniaAges 18 years+ - NCT07696572Recruiting
Testing a new device for EUS procedures
This trial is studying a new tool called the RIVOS™ EUS access device, which is used during a type of internal ultrasound called endoscopic ultrasound (EUS). The goal is to see how well it works for people who need this procedure.
Orlando, FloridaAges 18 years+ - NCT07696546Recruiting
Gallbladder drainage: tube or scope?
This trial compares two minimally invasive ways to drain an infected gallbladder when you are too sick or not a candidate for surgery. It will help determine which approach works better and has fewer side effects.
Orlando, FloridaAges 18 years+ - NCT05321745Recruiting
Fecal transplant for children with Crohn’s disease
This trial tests whether transferring stool microbes (called fecal microbiota transplantation, or FMT) can improve Crohn’s disease in children who have not gotten better with usual treatments. If you qualify, the study will check symptoms and colon imaging/score changes over the study follow-up.
Wuhan, HubeiAges 2–16 - NCT04976153RecruitingPhase 3
Stem cell implant to treat fecal urge incontinence
This Phase 3 study tests an implant made from a person’s own muscle-related cells to improve fecal “urge” leakage. It’s for adults whose symptoms haven’t improved enough with usual conservative treatments.
GrazAges 18 years+ - NCT07694674Recruiting
Comparing Biologic Drugs to Prevent Crohn's Return After Surgery
This trial compares different biologic medications to see which best prevents Crohn's disease from coming back after intestinal surgery. It may help you if you have had surgery for Crohn's and are starting a biologic drug soon after.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT05432648Recruiting
Fiber food introduction for children with short bowel syndrome
This trial tests if slowly adding fiber to the diet helps children with short bowel syndrome. It looks at how fiber affects digestion and overall health.
Philadelphia, PennsylvaniaAges 4 months–18 years - NCT03942328RecruitingPhase 1/Phase 2
Immune cell vaccine plus checkpoint treatment after liver radiation
This trial tests a combination of a personalized immune cell treatment (made from your own cells) and a pneumococcal vaccine along with an “immune checkpoint” drug after high-dose radiation for certain unresectable liver cancers. The goal is to help your immune system better attack the cancer and to see how safe and effective this approach is.
Rochester, MinnesotaAges 18 years+ - NCT05881005Recruiting
NAC for fatty liver in people with active Cushing’s
This study tests whether NAC (a supplement/medicine) can improve liver health in adults who have active Cushing’s syndrome and fatty liver disease. It may help if your excess stress hormone levels are affecting your liver.
AngersAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.