Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06491472RecruitingPhase 2
Ivonescimab with radiation and chemo for pancreatic cancer
This trial tests a new immunotherapy drug (ivonescimab) combined with targeted radiation and chemotherapy for people with pancreatic cancer. The goal is to see if this combination can shrink tumors and improve outcomes.
WuhanAges 18 years+ - NCT06492408RecruitingPhase 2
Immunotherapy before surgery for liver cancer
This trial tests giving two immunotherapy drugs directly into the tumor before surgery for liver cancer. It aims to see if this approach can shrink the tumor and improve outcomes for patients who are candidates for surgery.
Guanzhou, GuangdongAges 18–75 - NCT06492395RecruitingPhase 3
Three treatments for large liver cancer with portal vein spread
This trial tests adding a second liver-directed treatment (hepatic artery infusion) to the usual combination of targeted therapy (lenvatinib) and chemoembolization (DEB-TACE) for people with large liver cancer that has spread into the portal vein, to see if the triple therapy works better.
Guangzhou, GuangdongAges 18–75 - NCT06493032Recruiting
Gastric mapping to check G-POEM success
This study uses a non-invasive stomach-mapping test (BSGM) to see if a G-POEM procedure (a treatment for gastroparesis) works well. It may help doctors better understand how the stomach empties after the procedure.
Indianapolis, IndianaAges 18 years+ - NCT06493565Recruiting
Early scope check for leak after colorectal surgery
This trial tests whether a routine endoscopic exam shortly after colorectal surgery can catch a leak early, which may prevent complications. If you are 18 or older and had a low colorectal or coloanal anastomosis within 15 cm of the anorectal junction, you may be eligible.
BordeauxAges 18 years+ - NCT06493773Recruiting
Alcohol help for new liver disease diagnosis
This trial tests a program to help people recently diagnosed with alcohol-related liver disease cut back on drinking. If you qualify, you may get support to improve your liver health.
Køge, KøgeAges 18 years+ - NCT06493760RecruitingPhase 2
Testing a new drug for advanced colorectal cancer
This trial tests a new drug called SSGJ-707 for people with colorectal cancer that has spread. It aims to see if the drug can help shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06494826Recruiting
Study of gut bacteria and proteins in new Crohn's disease patients
This study looks at proteins from your body and gut bacteria to understand Crohn's disease better. You may join if you are about to have your first colonoscopy for suspected Crohn's and have not had any treatment yet.
AfulaAges 18 years+ - NCT06495333Recruiting
Gene and gut bacteria in Hispanic fatty liver patients
This study looks at how a gene variant (PNPLA3) relates to gut bacteria in Hispanic patients with fatty liver disease (MASLD) in Puerto Rico. It aims to understand the connection between your genes, your gut health, and your liver condition.
San JuanAges 21–75 - NCT06495606Recruiting
How stomach acid affects your voice
This study looks at how stomach acid backing up into the throat can change the voice. It may help find typical voice differences in people with acid reflux.
BernAges 18 years+ - NCT06495645Recruiting
Computer-aided endoscopy to find stomach growths
This trial tests a computer-aided system used during upper endoscopy to find stomach growths that might be missed. It may help improve detection of early stomach cancer or precancerous changes.
Hong KongAges 40 years+ - NCT06495658Recruiting
Prebiotics for ulcerative colitis symptoms
This trial tests whether a prebiotic supplement can improve symptoms of ulcerative colitis. It may be a good option for people with active symptoms who are already on stable medications.
Los Angeles, CaliforniaAges 18–85 - NCT06496191Recruiting
Fecal transplant for alcohol use in cirrhotics
This trial tests whether a fecal microbiota transplant (FMT) can help people with alcohol-related cirrhosis who are still drinking. It aims to see if FMT can reduce alcohol cravings and improve liver health.
New Delhi, National Capital Territory of DelhiAges 18–70 - NCT06496373RecruitingEarly Phase 1
mRNA vaccine plus immunotherapy after pancreatic cancer surgery
This trial tests a personalized mRNA vaccine combined with an immunotherapy drug (PD-1 inhibitor) to prevent pancreatic cancer from returning after surgery. It is for patients whose tumors have specific genetic features and who cannot have standard chemotherapy.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06497790Recruiting
Validating a swallowing screening for stroke patients
This study is testing a German version of a swallowing screening tool (BJH-SDS-G) for stroke patients. It aims to identify swallowing problems early.
Giesen, HesseAges 18–100 - NCT06497985RecruitingPhase 3
New drug combo for advanced colorectal cancer
This trial tests a combination of three drugs—tucidinostat, sintilimab, and bevacizumab—for people with a specific type of advanced colorectal cancer (MSS or pMMR) that has gotten worse after standard treatments. The goal is to see if this new mix can help shrink or slow the tumor.
Guangzhou, GuangdongAges 18–75 - NCT06498167Recruiting
Rinvoq safety study
This study is checking the safety of the medicine Rinvoq (upadacitinib) in people who have been prescribed it. It involves answering a few questions over the phone to help doctors understand how the medicine is working for you.
PortoAges 18 years+ - NCT06498622RecruitingPhase 2
Liver cancer relapse prevention after surgery
This trial tests a combination of two drugs (Donafenib and Envafolimab) after surgery to lower the risk of liver cancer coming back in people who have high-risk features. It may help if you qualify based on your tumor(s) and overall health.
Fuyang, AnhuiAges 18–80 - NCT06498817Recruiting
Cholera home care for diarrhea patients without running water
This trial tests a 7-day hospital-based program to help patients with diarrhea who lack running water at home. It aims to prevent the spread of cholera and improve recovery.
MānikganjAges Any age - NCT06498752RecruitingPhase 2
MRD-guided consolidation therapy after radiation for esophageal cancer
This trial looks at whether a treatment guided by a blood test (MRD) after radiation can help prevent esophageal cancer from coming back. It tests a personalized approach to decide if more treatment is needed.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06499792Recruiting
Nerve block for pain after pancreatic surgery
This trial looks at whether adding a nerve block (TAP block) to spinal anesthesia can reduce pain and the need for opioids after surgery to remove part of the pancreas (Whipple procedure). If you are scheduled for this type of surgery, this approach might help your recovery.
StrasbourgAges 18 years+ - NCT06500052RecruitingPhase 1
Study of BL-M17D1 for HER2-positive or low-expression digestive tract and other solid tumors
This trial tests a new drug called BL-M17D1 for people with advanced or metastatic HER2-positive or low-expression gastrointestinal cancer and other solid tumors. The goal is to see if it is safe and effective.
Guangzhou, GuangdongAges 18–75 - NCT06500468Recruiting
A capsule test for suspected upper GI bleeding
This trial tests a new ingestible capsule called PillSense that can detect bleeding in the upper part of your digestive system. If you come to the emergency room with signs of upper GI bleeding (like vomiting coffee-ground material or having black stools) but without obvious black stool on a physical exam, this study will see if the capsule works as well as the usual endoscopy procedure.
SingaporeAges 21–99 - NCT06500403Recruiting
Non-invasive tools for liver injury after chemotherapy
This study tests non-invasive methods to diagnose a liver condition called PSVD in people who have received platinum chemotherapy. It may help find liver problems early without a biopsy.
Guangzhou, GuangdongAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.