Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06500754Recruiting
Persistent intestinal damage in celiac disease on strict diet
This study looks at why some adults with celiac disease still have damage to their small intestine even after strictly avoiding gluten. It aims to understand persistent villous atrophy and could help improve long-term care for people like you.
Terrassa, BarcelonaAges 20–80 - NCT06501053Recruiting
Contact X-ray therapy for early rectal cancer
This trial tests a special type of contact X-ray (brachytherapy) for early-stage rectal cancer. It may help avoid major surgery by treating the tumor from inside the rectum.
Stockholm, SolnaAges 18 years+ - NCT06501482RecruitingPhase 3
FOLFIRI after liver surgery for colorectal cancer
This trial tests whether adding FOLFIRI chemotherapy after surgery for liver metastases from colorectal cancer can reduce the risk of the cancer coming back. It's for people whose liver tumors responded well to the same chemotherapy before surgery.
Paris, Île-de-France RegionAges 18 years+ - NCT06501742Recruiting
Major liver surgery and blood flow control study
This trial looks at how major liver surgery with controlled blood flow (vascular clamping) affects patients. It may help doctors improve outcomes for people who need this type of operation.
StrasbourgAges 18 years+ - NCT06502275Recruiting
Nutrition and Exercise for Older Colorectal Cancer Patients
This trial tests a nutrition and exercise program designed for older adults with colorectal cancer. It uses a smartphone app to help you stay active and eat well at home.
Chiayi CityAges 60 years+ - NCT06502704Recruiting
Bile acids and gut bacteria in early colorectal cancer
This trial studies how bile acids and gut bacteria are linked to early colorectal cancer. It may help identify patients at risk before cancer develops.
VilniusAges 18 years+ - NCT06502834RecruitingPhase 1
Testing a probiotic supplement for overweight people
This trial studies a supplement called D. piger to see if it's safe and how it affects alcohol breakdown in overweight adults with insulin resistance. You would take the supplement daily for 4 weeks.
AmsterdamAges 18–70 - NCT06502873Recruiting
Study of colon samples in IBD and healthy people
This study is gathering information from people with active Crohn's disease or ulcerative colitis, and from people without IBD. Researchers will look at samples from the colon to learn more about these conditions.
LiègeAges 18 years+ - NCT06503068Recruiting
Liver disease name stigma and quality of life study
This study looks at how the names of two liver conditions (NAFLD and MAFLD) affect how patients feel about their illness and their quality of life. If you have NAFLD or NASH, you can help by filling out a survey.
Tanta, GharbyeaAges 18 years+ - NCT06503146RecruitingPhase 2
New imaging tracer for detecting various cancers
This trial tests a new imaging agent, [18F]FAPI-74, which might help detect certain cancers more clearly. The scan looks for a protein called fibroblast activation protein (FAP) that is often found in tumors. If you have one of the listed cancers and are about to start treatment, this study could help doctors see where the cancer is and how it responds to therapy.
Bethesda, MarylandAges 18–120 - NCT06504147RecruitingPhase 2
Radspherin for ovarian cancer with peritoneal spread
This trial tests a radioactive treatment called Radspherin given during surgery for advanced ovarian cancer that has spread to the lining of the abdomen. It is for people whose tumors are HR proficient (a specific genetic type) and who have already had chemotherapy before surgery.
Tampa, FloridaAges 18 years+ - NCT06504485Recruiting
Study of bulevirtide for chronic hepatitis B and D
This trial tests a drug called bulevirtide for people with chronic hepatitis B and D (HDV) co-infection. It looks at how the immune system and virus respond to treatment.
MilanAges 18 years+ - NCT06504589Recruiting
Study for CF treatments for people without modulators
This study tests new treatments for cystic fibrosis in people who cannot take or choose not to take current CFTR modulators. It aims to find better options for managing CF.
Birmingham, AlabamaAges 12 years+ - NCT06504732RecruitingPhase 2/Phase 3
IAH0968 plus CAPEOX for HER2-positive gastric cancer
This trial tests a new drug (IAH0968) combined with chemotherapy (CAPEOX) for people with HER2-positive stomach or gastroesophageal junction cancer that has not been treated before or has spread.
Harbin, HeilongjiangAges 18–75 - NCT06505304Recruiting
AI endoscopy to predict Crohn's return after surgery
This trial uses artificial intelligence during colonoscopy to predict if Crohn's disease will come back after surgery. It aims to improve early detection and guide treatment decisions.
LeuvenAges 18–75 - NCT06505603Recruiting
PiMZ alpha-1 deficiency progression study
This study is looking at people with a specific mild form of alpha-1 antitrypsin deficiency (PiMZ) to understand how their lung disease progresses over time. It involves lung function tests and CT scans, and may help researchers learn more about the condition.
Birmingham, AlabamaAges 18 years+ - NCT06506318Recruiting
Predicting drug-resistant liver abscess with deep learning
This trial uses a computer model based on deep learning to predict whether a bacterial liver abscess will be resistant to multiple antibiotics. It looks at your CT scan images to help doctors choose the right treatment sooner.
Shenyang, LiaoningAges 18 years+ - NCT06506734Recruiting
Dental color changes and quality of life in early jaundice
This study looks at how early and long-lasting jaundice (high bilirubin levels) affects tooth color and quality of life in children with certain liver conditions. It aims to understand these effects to improve care.
BordeauxAges 12–18 - NCT06507683Recruiting
Radiation plus ripretinib for advanced GIST
This trial tests whether adding radiation therapy to the drug ripretinib can help people with advanced gastrointestinal stromal tumors (GIST) that can't be removed by surgery and have stopped responding to other treatments. It aims to see if this combination is safe and effective.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06507956Recruiting
Physical activity and sitting habits in adults with cystic fibrosis
This study looks at how physically active and sedentary adults with cystic fibrosis are. It uses a device to measure your daily movement and asks you to fill out a few questionnaires. The goal is to better understand your activity patterns and find ways to help you stay healthy.
Pierre-BéniteAges 18–65 - NCT06508190Recruiting
Walking exercise for sleep apnea and fatty liver
This trial tests whether a simple walking program can help people who have both obstructive sleep apnea and non-alcoholic fatty liver disease. If you have these conditions and a BMI under 35, you may be able to join a free exercise program to see if it improves your health.
GizaAges 40–65 - NCT06508307RecruitingPhase 1
A study of an injected virus for advanced solid tumors
This trial tests a new treatment where a virus (GC001) is injected directly into a tumor. The virus is designed to attack cancer cells and may help people with advanced solid tumors that haven't responded to other treatments.
Zhengzhou, HenanAges 18–75 - NCT06508502Recruiting
Pancreatitis Severity and Gut Bacteria Study
This study looks at how the bacteria in your gut (microbiome) might affect the severity of a first-time acute pancreatitis attack. It aims to see if certain gut bacteria can predict how serious the illness will be, which could help doctors treat patients better.
Göttingen, Lower SaxonyAges 18 years+ - NCT06509126RecruitingPhase 3
Panitumumab with Chemo: Continuous or Intermittent for Advanced CRC
This trial compares giving panitumumab plus FOLFIRI (two chemotherapy drugs) either continuously or with breaks, as a first treatment for left-sided colorectal cancer that has spread. It's for people whose tumors have certain genetic markers (RAS/BRAF wild-type) and haven't had treatments for advanced disease before.
NaplesAges 18–100
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.