Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,908 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,188
- Phase 1584
- Phase 3466
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas148
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,908 total
- NCT07371273RecruitingPhase 2
Comparing three surgeries for low rectal cancer
This trial tests three different surgical methods for rectal cancer located very close to the anal canal. The goal is to see which method works best in the short and long term while preserving anal function.
ShanghaiAges 18–75 - NCT07371663RecruitingPhase 1/Phase 2
TCC1727 combination therapy for advanced solid tumors
This trial tests a new drug, TCC1727, combined with other treatments for people with advanced solid tumors that have stopped responding to standard therapy. It aims to see if these combinations can help shrink or control the cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07371767RecruitingEarly Phase 1
Gene editing for high triglycerides in kids with FCS
This trial tests a new gene-editing treatment (CS-121) for children and teens with a rare inherited condition called Familial Chylomicronemia Syndrome (FCS). It aims to lower very high triglyceride levels and reduce the risk of pancreatitis.
Shanghai, Shanghai MunicipalityAges 4–18 - NCT07371832Recruiting
AI Stapler vs. Standard Stapler for Colorectal Cancer Surgery
This trial compares a new AI-assisted robotic stapler to a standard stapler used during surgery for colorectal cancer that has not spread. The goal is to see if the new stapler is safer and works better.
Hyderabad, TelanganaAges 18–80 - NCT07372300RecruitingPhase 3
Heat therapy plus standard care for advanced rectal cancer
This trial tests whether adding modulated electro-hyperthermia (a gentle heat treatment) to standard therapy (radiation and chemotherapy) before surgery helps control locally advanced rectal cancer. It is for people whose cancer has not spread to other parts of the body.
Chiayi City, Dalin TownshipAges 20 years+ - NCT07373457RecruitingPhase 1
Testing a new drug in healthy volunteers
This early-stage study tests a new investigational drug called HW201877 in healthy volunteers. The goal is to see if the drug is safe and how the body processes it.
ChangchunAges 18–55 - NCT07375680Recruiting
Blood sugar and stomach emptying study before surgery
This study uses a simple stomach ultrasound before surgery to see how fast your stomach empties. It compares that to your HbA1c (a measure of average blood sugar) to better understand how diabetes might affect digestion during anesthesia.
Kütahya, KütahyaAges 18–70 - NCT07374471RecruitingPhase 1/Phase 2
Testing MB-001 for moderate to severe ulcerative colitis
This study tests an investigational drug called MB-001 for people with moderate to severe ulcerative colitis who have already tried standard treatments without success. It aims to see if the drug is safe and helps control inflammation.
ChisinauAges 18–75 - NCT07374731Recruiting
Finding early signs of stomach cancer risk
This study looks for markers in the blood that could show if someone is at risk for stomach cancer or pre-cancerous changes. It aims to help catch problems earlier.
Aviano, PordenoneAges 18–100 - NCT07375147Recruiting
Comparing two ways to fix a rectocele through the anus or vagina
This trial tests if fixing an anterior rectocele through the anus works just as well as through the vagina. It’s for women who have trouble with bowel movements because of a rectocele that is at least 3 cm and hasn’t gotten better with changes in diet or lifestyle.
Cairo, Al-Manial, Cairo, EgyptAges 18 years+ - NCT07375420Recruiting
Exercise before treatment for oesophageal cancer
This trial tests whether a short exercise program before chemotherapy and surgery can help people with advanced oesophageal cancer recover better and feel stronger. Participants will do supervised exercise sessions before starting their cancer treatment.
Guildford, SurreyAges Any age - NCT07376707RecruitingPhase 1
Study of TGI-5 alone or with nivolumab for advanced solid tumors
This trial tests a new drug called TGI-5, either by itself or combined with another drug (nivolumab), for people with advanced cancer that hasn't responded to standard treatments. It's looking for patients with certain types of solid tumors, especially colorectal, melanoma, lung, or others that have stopped responding to therapy.
ShanghaiAges 18 years+ - NCT07377188Recruiting
Pregnancy and Inflammatory Bowel Disease Study
This trial looks at how pregnancy affects and is affected by inflammatory bowel disease. It aims to learn more to help women with IBD who are or want to become pregnant.
AmiensAges 18–50 - NCT07377487Recruiting
TheraSphere for liver cancer before market in Japan
This trial tests a treatment called TheraSphere for people with liver cancer that hasn't responded to standard care or can't have it. TheraSphere uses tiny radioactive beads to target tumors in the liver, and this study is being done to get it approved in Japan.
Nishinomiya, HyōgoAges 18 years+ - NCT07378436RecruitingEarly Phase 1
Testing a new drug for cancer-related belly fluid
This early-phase trial tests an experimental drug called GK02 for people with advanced cancer who have fluid buildup in the belly (malignant ascites). The drug is given directly into the belly to try to reduce the fluid and control symptoms.
BeijingAges 18–75 - NCT07378709Recruiting
Blood markers for TACE-treated liver cancer
This study is looking for blood markers that may help doctors learn how well TACE treatment is working for liver cancer. You need to be scheduled for TACE and have a follow-up scan to participate.
BelgradeAges 18 years+ - NCT07379047RecruitingPhase 2/Phase 3
Testing NB003 for advanced GIST after prior treatments
This trial tests a new drug called NB003 for people with advanced GIST (a type of stomach or intestinal tumor) that has stopped responding to or could not be tolerated after standard treatments like imatinib or sunitinib. The goal is to see if NB003 can help shrink or control the tumor.
Hefei, AnhuiAges 18 years+ - NCT07381322Recruiting
Tracking rectal cancer response to immunotherapy with MRI scans
This study uses special MRI scans taken before and during immunotherapy to see if the cancer is truly growing or just appearing to grow, which is called 'pseudoprogression'. It helps doctors better understand how well the treatment is working for rectal cancer.
Guangzhou, GuangdongAges Any age - NCT07382791Recruiting
Stomach emptying after pancreas surgery
This study looks at how the stomach empties after pancreas surgery. It aims to understand and possibly help with slow stomach emptying, a common issue after this operation.
Taipei, TaiwnAges 20–75 - NCT07383844Recruiting
Physical activity for teens with IBD
This study looks at what helps or stops teenagers with inflammatory bowel disease (Crohn's disease or ulcerative colitis) from being physically active. It involves completing questionnaires and an interview to understand your experience.
NiceAges 10–17 - NCT07383935Recruiting
Stress ball use during chemotherapy for GI cancer patients
This study tests whether using a stress ball during chemotherapy helps patients with gastrointestinal cancer feel better. It may reduce stress or discomfort during treatment.
ArtvinAges 18 years+ - NCT07385001RecruitingPhase 1/Phase 2
Ivonescimab with chemotherapy before surgery for esophageal cancer
This trial tests a new drug called Ivonescimab (AK112) combined with two chemotherapy drugs (Abraxane and cisplatin) given before surgery for esophageal cancer. The goal is to see if this combination can shrink tumors and improve surgery outcomes for patients with locally advanced disease.
Xi'an, ShannxiAges 18–75 - NCT07385131Recruiting
Steroid before infliximab for inflammatory bowel disease
This study tests whether giving a steroid (dexamethasone) before an infliximab infusion can prevent allergic reactions in people with moderate-to-severe Crohn's disease or ulcerative colitis. If you qualify, you will receive either the steroid or a placebo before your infliximab treatment.
Hangzhou, ZhejiangAges 14–80 - NCT07385196Recruiting
Understanding symptoms after ileorectal surgery
This study observes patients who have had a surgery connecting the small intestine to the rectum (ileorectal anastomosis) or who kept their rectum after colon surgery. Researchers want to better understand what symptoms these patients experience, which could help improve care.
DiyarbakırAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,908 recruiting gastroenterology studies from the U.S. registry right now, out of 12,480 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.