Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT07217704RecruitingPhase 3
New PET scan to find stomach or esophageal cancer spread
This trial tests a new PET scan drug (18F-FAPI) to see if it can better detect where stomach or esophageal cancer has spread. It may help doctors plan the right treatment for you.
Cerritos, CaliforniaAges 18 years+ - NCT04867590Recruiting
EndoRotor vs radiofrequency treatment for Barrett’s esophagus
This study compares two endoscopic treatments to remove abnormal cells in Barrett’s esophagus and lower the chance of it worsening. If you qualify, you may be assigned to one of the two procedures and followed to see how well they work and how safe they are.
BesançonAges 18 years+ - NCT07616687RecruitingPhase 4
Testing guselkumab to improve Crohn's disease control
This study tests whether guselkumab, a newer biologic medication, can better control active Crohn's disease symptoms and inflammation. You'll receive the medication and be monitored closely to see how well it works for you.
AmiensAges 18 years+ - NCT07533890Recruiting
Probiotics and gut health in children with inflammatory bowel disease
This study tests whether a multi-strain probiotic supplement can change the gut bacteria in children and teens with inflammatory bowel disease (IBD). Researchers will collect stool samples to see if the probiotics help restore healthy gut bacteria and potentially improve symptoms.
BernAges 5–18 - NCT03123835Enrolling by invitation
Testing POEM and other procedures for reflux and swallowing problems
This trial studies how well POEM and other endoscopy-based (through-the mouth) treatments work for conditions like acid reflux, achalasia (trouble moving food), and Barrett’s esophagus. It may help doctors compare outcomes and choose the safest, most effective procedure for your situation.
Sacramento, CaliforniaAges 18–80 - NCT02796937Enrolling by invitationPhase 3
Long-term safety study of a blood protein for Alpha-1
This study checks how safe a prescribed blood protein medicine (alpha-1 proteinase inhibitor) is over the long term in people with Alpha-1 antitrypsin deficiency. You may join if you already finished an earlier study or if your lung function has been declining.
Phoenix, ArizonaAges 20–72 - NCT02699736Enrolling by invitation
HIV and hepatitis C study in European adults
This study follows people living with HIV who also have hepatitis C antibodies, to better understand how HIV and hepatitis C affect health over time. You may be able to join if you meet the age and enrollment requirements, even if your hepatitis C virus level is currently undetectable.
Buenos AiresAges 16 years+ - NCT02393703Recruiting
Testing blood signals from tiny cell packets in pancreatic surgery
This study looks at how tiny particles in blood (“exosomes”) carry signals between cells in people having pancreatic surgery. The goal is to understand these signals in different pancreatic conditions and treatment situations, which may help future care.
New York, New YorkAges 18 years+ - NCT02422875Enrolling by invitation
Study of immune markers in autoimmune disease and lupus
This study looks at blood and immune cell markers (autoantibodies and immune cell “signatures”) to better understand autoimmune conditions, including lupus. It may help researchers identify which markers are linked to disease and how immune cells respond after vaccination.
Atlanta, GeorgiaAges 18 years+ - NCT02202681Enrolling by invitation
Swallowable capsule scans the duodenum with special imaging
This study tests whether a swallowable imaging capsule can safely look at the duodenum (the first part of the small intestine). It may help researchers better understand gut lining changes, such as those seen in celiac disease.
Boston, MassachusettsAges 16 years+ - NCT02636517Enrolling by invitationPhase 1
Fecal microbiome transplant for repeat C. difficile infection
This Phase 1 study tests whether transferring healthy gut bacteria (a fecal microbiome transplant) can help children with repeated or moderate-to-severe C. difficile infection. It focuses on changing gut bacteria to reduce ongoing infection and symptoms.
Philadelphia, PennsylvaniaAges 3–21 - NCT02770859Enrolling by invitation
POEM treatment for achalasia, research database study
This is a study that collects information in a research database for adults with achalasia who are referred for POEM, a procedure to help food move more easily. It may help researchers understand outcomes and care for people with achalasia.
Indianapolis, IndianaAges 18 years+ - NCT02471170Enrolling by invitation
Taking blood samples for pancreatic and related cancer research
This study asks people receiving care at the University of Pennsylvania Hospital to provide samples that can help researchers study tumor material. If you have pancreatic disease—or you’re getting care for something else (like a routine colonoscopy)—your samples may be used to compare findings and improve future research.
Philadelphia, PennsylvaniaAges 18 years+ - NCT02172651RecruitingEarly Phase 1
Vitamin D during early colon cancer or liver surgery
This trial studies whether taking higher-dose vitamin D3 around the time of colon cancer (or colon cancer with resectable liver metastases) surgery improves outcomes. It focuses on safety and possible effects on cancer-related health after surgery.
Boston, MassachusettsAges 18 years+ - NCT02791854Enrolling by invitation
Improving Care for Adults With Crohn’s or Ulcerative Colitis
This trial looks at ways to improve care for adults living with inflammatory bowel disease, including Crohn’s disease and ulcerative colitis. You may be invited if your clinic is part of an inflammatory bowel disease care network called IBD Qorus.
Los Angeles, CaliforniaAges 18–99 - NCT02422238Recruiting
Study of fatty liver in adults, using MRI and stored samples
This study follows people with nonalcoholic fatty liver disease to better understand the condition. It uses an MRI scan and collects body samples to help researchers study changes over time.
Maastricht, LimburgAges 18–65 - NCT02600949Enrolling by invitationPhase 1
Peptide vaccine study for advanced pancreatic or colon cancer
This Phase 1 study tests a personalized vaccine made from a patient’s tumor to help the immune system recognize and attack cancer. It is for people with advanced pancreatic or colorectal cancer (often after surgery or while metastatic) and aims to see if the approach is safe and can help immune control of the cancer.
Houston, TexasAges 18 years+ - NCT02137668RecruitingPhase 1
Testing vancomycin for certain pediatric bile duct conditions
This early-phase study tests whether the antibiotic vancomycin can help children with primary sclerosing cholangitis or biliary atresia, and related gut/bile duct problems. It may work by changing gut bacteria, but you would need to avoid certain medicines beforehand.
Sacramento, CaliforniaAges 2 weeks–40 years - NCT02427269Enrolling by invitation
Blood and tissue sample study for esophagus conditions
This study collects blood and biopsy tissue from people who are having an upper endoscopy at UNC for Barrett’s esophagus or esophageal cancer. The samples help researchers build a biorepository to study these conditions and support future research.
Chapel Hill, North CarolinaAges 18 years+ - NCT02081755Enrolling by invitationPhase 4
Everolimus after liver transplant to lower liver cancer return
This trial studies whether everolimus, a transplant medicine, can safely reduce the chance that liver cancer comes back after liver transplant. It compares how well the treatment works while carefully monitoring side effects and safety.
San Francisco, CaliforniaAges 18 years+ - NCT01832324Enrolling by invitation
Study the causes of food allergy using blood samples
This study looks for the biological reasons behind food allergies by collecting a small amount of blood. It may help scientists better understand different types of food allergy and eventually improve diagnosis or treatments.
Philadelphia, PennsylvaniaAges 1 month–65 years - NCT00983463Enrolling by invitation
Study of liver fats and proteins in fatty liver disease
This study measures different fats and proteins in the liver of people with fatty liver disease (often called NAFLD) who are having planned abdominal or weight-loss surgery. It may help doctors better understand what’s happening in the liver and improve future care.
Nashville, TennesseeAges 18–65 - NCT01171872Enrolling by invitation
Study blood and tissue gene signals in bowel inflammation
This study looks at gene activity (what your body’s genes are “doing”) in people with bowel inflammation during endoscopy or bowel surgery. It may help researchers understand inflammatory bowel disease and improve future diagnosis or treatments.
Baltimore, MarylandAges 7 years+ - NCT00068003Enrolling by invitation
Harvesting Cancer Cells for Experimental Treatment
This trial collects immune cells from cancer patients or healthy volunteers to develop new experimental cancer treatments. Researchers will take a sample of your tumor or blood cells, grow them in the lab, and study how to use them to fight your cancer.
Bethesda, MarylandAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.