Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT01492231Enrolling by invitation
Study outcomes from endoscopy procedures at a digestive center
This trial collects information about how interventional endoscopy procedures affect patients and outcomes after the procedure. You may be able to join if you’re an adult and scheduled for an endoscopy procedure at the specified digestive disease center.
Orange, CaliforniaAges 18 years+ - NCT00587314Enrolling by invitation
Testing ablation treatment for Barrett’s with precancer changes
This trial studies whether an “ablation” procedure (destroying abnormal esophagus lining) works well for people with Barrett’s esophagus that has high-grade precancer changes or very early cancer. It may help find safer or more effective ways to prevent the condition from worsening.
Rochester, MinnesotaAges 18–90 - NCT00884455Enrolling by invitation
Join the Alpha-1 DNA and tissue sample bank
This trial is a DNA and tissue sample registry for people interested in Alpha-1. It helps researchers study the condition by collecting samples for future research.
Gainesville, FloridaAges birth–100 years - NCT07398339RecruitingPhase 2
Photodynamic therapy for bile duct cancer
This trial tests a light-activated drug called cosiporfin sodium for people with advanced bile duct cancer that cannot be surgically removed. The treatment targets tumors in the bile ducts and may help shrink them.
Shanghai, Pudong New AreaAges 18 years+ - NCT07398326RecruitingPhase 2
Drug combo for advanced colorectal cancer that hasn't spread to the liver
This trial tests a combination of two drugs (anlotinib and sintilimab) as a first treatment for people with advanced colorectal cancer that has spread to places other than the liver, who do not want chemotherapy. The goal is to see if this targeted therapy can help control the cancer.
ShanghaiAges 18 years+ - NCT07399353Recruiting
Comparing two surgeries for high anal fistula
This study compares two surgical techniques (fistula rerouting and LIFT) for treating a high perianal fistula, a tunnel that forms in the muscle around the anus. It aims to find which method works better for people with this condition.
Cairo, Al-Manial CairoAges 20–65 - NCT07399652Recruiting
AI to see blood vessels during special endoscopy for swallowing issues
This trial is testing a computer system that helps doctors see blood vessels more clearly during a special type of endoscopy called third-space endoscopy. It aims to make the procedure safer for people with swallowing disorders or certain growths in the digestive tract.
Hyderabad, TelanganaAges Any age - NCT07399860RecruitingPhase 2
Botox before hemorrhoid surgery to reduce pain after surgery
This trial tests whether injecting botulinum toxin (Botox) into the anal muscle before hemorrhoid removal surgery can lower pain after the operation. It is for people with advanced hemorrhoids that have not gotten better with other treatments and who are already planning to have surgery.
Moscow, MoscowAges 18 years+ - NCT07400328RecruitingPhase 2
Stem cell injection to prevent severe mouth sores in transplant
This trial is testing a single injection called Amimestrocel to prevent severe mouth sores in people getting a stem cell transplant. The study is for adults who are receiving high-dose conditioning with total body irradiation or melphalan, which often cause painful mouth inflammation.
Suzhu, JiangsuAges 18–65 - NCT07400354Recruiting
PD-1 drug plus chemo for advanced stomach cancer based on gut bacteria
This trial tests if adding a PD-1 immunotherapy drug to standard chemotherapy works better for advanced stomach cancer, and looks at how your gut bacteria may affect treatment. It is for people who have not had chemotherapy before and are starting their first treatment.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07400367Recruiting
Probiotics and lifestyle changes for fatty liver disease
This trial tests whether taking probiotics plus making lifestyle changes can improve fatty liver and metabolic health. You may qualify if you have liver fat and at least one sign of metabolic problems like high blood sugar or high blood pressure.
New Taipei CityAges 18–80 - NCT07400783Recruiting
Study of short bowel syndrome in children
This study looks at short bowel syndrome in children who have had intestinal surgery. It may help doctors understand how to better treat this condition.
Florence, FlorenceAges 4 months–17 years - NCT07401173Recruiting
Computer tool to predict stomach cancer surgery complications
This trial uses a computer tool (DeepComp) to analyze your CT scan and predict possible complications after stomach cancer surgery. It may help doctors prepare for your recovery.
Shijiazhuang, None SelectedAges 18–85 - NCT07401199Recruiting
AI predicts immunotherapy response in advanced stomach cancer
This trial uses artificial intelligence to analyze CT scans, blood, and tumor tissue to predict how well your cancer will respond to chemotherapy and immunotherapy before surgery. It aims to personalize treatment for locally advanced stomach or gastroesophageal junction cancer.
Fuyang, AnhuiAges 18 years+ - NCT07401680RecruitingPhase 1
Stool transplant for active ulcerative colitis
This trial tests whether a stool transplant (fecal microbiota transplantation) can help manage active ulcerative colitis. You would receive a transplant from a healthy donor to see if it improves your symptoms.
Calgary, AlbertaAges 18 years+ - NCT07401862RecruitingPhase 1
Study of Eloralintide in people with different levels of liver damage
This trial tests a new medicine called eloralintide in people with healthy livers and in those with mild, moderate, or severe liver damage. It helps researchers learn how the liver affects the medicine in the body.
Orlando, FloridaAges 18–85 - NCT07402083Recruiting
Testing a treatment from donor breast milk for early preterm babies
This trial studies a treatment made from special particles in donor breast milk, given to very early-born babies who are at risk of a serious gut infection called NEC. It aims to see if these particles can help protect their intestines.
Valencia, ValenciaAges birth–2 weeks - NCT07403630Recruiting
Tumor chemogenomic profiler for cancer patients of all ages
This trial uses a new testing platform to analyze the genes and proteins in your tumor, aiming to find the most effective treatments for people with cancer that has come back, is not responding to treatment, or has spread. It is designed for both children and adults with any type of blood cancer or solid tumor.
Palermo, PalermoAges 1 year+ - NCT07404774Recruiting
stitch and laser treatment for hemorrhoids
This trial is testing a combined treatment for hemorrhoids that are causing symptoms. It uses a technique to stitch the hemorrhoid tissue back in place (suture mucopexy) plus a laser to shrink blood vessels. The goal is to see if this approach works well for people with grades II, III, or IV hemorrhoids, even if they've had other treatments before.
AthensAges 18 years+ - NCT07405086RecruitingPhase 4
Morning vs. afternoon immunotherapy for advanced solid tumors
This trial compares giving immunotherapy in the morning versus the afternoon to see if timing affects how well it works. It is for people with certain types of advanced or metastatic solid tumors who have not had this treatment before.
Portland, OregonAges 18 years+ - NCT07405476RecruitingPhase 2
Zanidatamab before surgery for HER2 positive colon or rectal cancer
This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.
Atlanta, GeorgiaAges 18 years+ - NCT07405931Recruiting
Managing chemo side effects with phone calls and a smartphone app
This study tests whether checking in by phone or smartphone app can help manage chemotherapy side effects. If you are starting a new chemo for stomach, lung, breast, or colon cancer, this program may support you from home.
BusanAges 19 years+ - NCT07406698Recruiting
Best timing for endoscopy in infected pancreatitis
This trial studies the best timing for using a camera down your throat to drain infected fluid pockets from severe pancreatitis. It is for people who are still in the hospital with signs of infection and who can have the procedure done within the first 26 days of their illness.
Orlando, FloridaAges 18 years+ - NCT07406945Recruiting
Testing a new tool during POEM for swallowing problems
This trial tests a new tool (SpydrBlade) during a procedure called POEM to help people with swallowing problems like achalasia. The goal is to see if it's safe and works well.
GuayaquilAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.