Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT07290764Enrolling by invitation
Surgery vs observation for liver cancer that responded to drug therapy
This trial looks at whether people with an initially untreatable liver cancer that has shrunk or disappeared after drug therapy should have surgery or just continue monitoring. It aims to see which approach helps people live longer.
Fuzhou, FujianAges 18–75 - NCT07289672Enrolling by invitation
Food limits in Crohn's and colitis
This study looks at how diet affects people with Crohn's disease or ulcerative colitis who have moderate inflammation. It aims to understand if certain foods make symptoms worse or better.
MalmöAges 18 years+ - NCT07289568Enrolling by invitation
Comparing surgery types for splenic flexure cancer
This study looks at two types of surgery for cancer in a part of the colon called the splenic flexure. It compares removing just the affected section (segmental colectomy) with removing a larger portion (extended hemicolectomy) to see which has better outcomes.
Istanbul, IstanbulAges 18–80 - NCT07257588Enrolling by invitation
Hyperbaric oxygen for severe ulcerative colitis
This study tests whether adding hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—to standard care can help people with a severe flare of ulcerative colitis (a type of inflammatory bowel disease). It may reduce inflammation and speed up recovery.
Xi'an, ShaanxiAges 18 years+ - NCT07254208Enrolling by invitation
Long-term study for those who took PBGENE-HBV
This study follows people who have already received the experimental gene therapy PBGENE-HBV for hepatitis B. It aims to monitor long-term safety and health outcomes.
Boston, MassachusettsAges 19–80 - NCT07253298Enrolling by invitation
Kegel exercises with biofeedback for bowel recovery after rectal cancer surgery
This trial studies whether doing Kegel exercises with biofeedback (a technique that helps you see how your muscles are working) can improve bowel function, reduce emotional distress, and boost quality of life after rectal cancer surgery.
TaipeiAges 18 years+ - NCT07248722Enrolling by invitation
Pantoprazole after preventive variceal treatment
This trial tests whether a heartburn medication (pantoprazole) helps patients with liver cirrhosis who have had a procedure to treat enlarged veins in the esophagus or stomach. It looks at how well the medicine works when given after this procedure to prevent complications.
Shenyang, LiaoningAges 18 years+ - NCT07230795Enrolling by invitation
AI-guided colorectal cancer screening for adults 45-49
This trial tests whether a computer program can help more adults ages 45-49 get screened for colorectal cancer. If you are due for screening and see a Penn Medicine doctor, you may be able to join.
Philadelphia, PennsylvaniaAges 45–49 - NCT07222189Enrolling by invitationPhase 2
Long-term safety of an experimental drug for Crohn's or colitis
This study looks at the long-term safety and side effects of an investigational drug called balinatunfib in people with Crohn's disease or ulcerative colitis. It is for patients who have already completed a full year of treatment in a previous related study.
Gorna OryahovitsaAges 19–77 - NCT07218003Enrolling by invitationPhase 1
Study of RNDO-564 alone or with pembrolizumab for bladder cancer
This trial tests an experimental drug, RNDO-564, either by itself or combined with another drug (pembrolizumab), for people with advanced bladder cancer or other solid tumors that have stopped responding to standard treatments. The goal is to see if it can shrink tumors or slow cancer growth.
San Francisco, CaliforniaAges 18 years+ - NCT07212491Enrolling by invitation
New ways to detect early esophageal changes in Barrett's esophagus
This study tests a new, less invasive way to detect precancerous changes or early cancer in Barrett's esophagus. It uses a sponge or brush to collect cells from your esophagus during a routine endoscopy, which may help find problems earlier and avoid more invasive procedures.
Scottsdale, ArizonaAges 18–90 - NCT07198945Enrolling by invitation
6 vs 12 month follow-up after large colon polyp removal
This trial compares whether a follow-up colonoscopy at 6 or 12 months is better for people who have had a large polyp (20-50 mm) removed. It will help doctors understand the best timing for surveillance.
Birmingham, AlabamaAges 18 years+ - NCT07176455Enrolling by invitation
Dietary habits after stomach cancer surgery
This trial studies how older stomach cancer survivors' eating habits change after surgery and tests ways to help them eat healthier. It focuses on people who just had their stomach cancer removed.
NanjingAges 60 years+ - NCT07171515Enrolling by invitation
Pancreatic Cancer Registry Study
This study collects information from people diagnosed with pancreatic cancer. It aims to improve care by learning from your medical records.
Goyang, GyeonggidoAges 19 years+ - NCT07167836Enrolling by invitation
Automated care pathway for inflammatory bowel disease
This study uses an automated system to help manage care for people with inflammatory bowel disease (IBD) at UT Southwestern. It aims to see if this digital tool can improve treatment and follow-up for patients already taking IBD medications.
Dallas, TexasAges Any age - NCT07166588Enrolling by invitation
Precision medicine study for inflammatory bowel disease
This study looks at using precision medicine to treat inflammatory bowel disease (IBD) in people who are newly diagnosed or already being monitored. It aims to find better ways to manage the condition.
Seoul, SeoulAges 10 years+ - NCT07159581Enrolling by invitation
Gene therapy for Wilson disease study with PET scans
This trial uses a special PET scan with a copper tracer to see how well gene therapy is working in people with Wilson disease. It may help doctors understand if the treatment is helping your body handle copper properly.
Aarhus, Aarhus NAges 18 years+ - NCT07155616Enrolling by invitation
Blood flow measurement from CT scan before Whipple surgery
This study uses a computer tool to measure blood flow in the arteries from your CT scan before a Whipple procedure. It may help doctors better plan your surgery.
Barcelona, BarcelonaAges 18 years+ - NCT07154784Enrolling by invitationPhase 2/Phase 3
Fecal transplant for long-term ulcerative colitis treatment
This trial tests whether fecal microbiota transplantation (FMT) can safely and effectively treat mild to moderate ulcerative colitis over the long term. FMT involves transferring stool from a healthy donor to restore a healthy balance of gut bacteria.
Seoul, Dongjak-guAges 10–80 - NCT07140289Enrolling by invitation
GLP-1 drugs and stomach emptying before surgery
This study looks at how GLP-1 medications affect the time it takes for your stomach to empty before anesthesia. It may help doctors decide if you need to take special precautions before your surgery.
Detroit, MichiganAges 18–90 - NCT07128953Enrolling by invitationEarly Phase 1
Zuoqing San for anal fistula wound healing
This study tests if a traditional Chinese medicine called Zuoqing San can help heal the wound after anal fistula surgery better by reducing certain inflammatory processes. It may be an option for people who have had surgery for a simple anal fistula and whose wound is a specific size.
Hefei, AnhuiAges 18 years+ - NCT07127952Enrolling by invitation
Nail fold test for stomach blood vessel condition
This study looks at whether a simple nail fold test can detect changes in small blood vessels that match changes seen in the stomach. It may help people with a stomach condition called GAVE, especially if they also have a connective tissue disease.
Jacksonville, FloridaAges 18–95 - NCT07121478Enrolling by invitationPhase 2
Testing a new treatment for pancreatic neuroendocrine tumors
This trial is for people with high-grade pancreatic neuroendocrine tumors (a type of pancreas cancer) whose previous treatments stopped working. It tests whether a new approach can help when standard options have failed.
Goyang-si, Gyeonggi-doAges 19 years+ - NCT07116668Enrolling by invitation
Colovac device study for colon surgery patients
This trial tests a device called Colovac that protects the connection made during colon surgery for cancer. It may help patients who need a temporary colostomy bag heal better.
Los Angeles, CaliforniaAges 22 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.