Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07535112RecruitingPhase 1
Testing BAY 3771249 for Advanced Colorectal Cancer With KRAS Mutation
This early-stage study tests a new drug called BAY 3771249 in people with advanced colorectal cancer that has a specific genetic change (KRAS G12D mutation). Researchers want to learn if it's safe and whether it helps shrink tumors.
Phoenix, ArizonaAges 18 years+ - NCT07716176RecruitingPhase 3
Ear stimulation plus meds for chemo-related nausea
This trial tests adding a simple ear-point stimulation to standard anti-nausea medicine for women receiving chemotherapy after breast cancer surgery. The goal is to see if this combination works better to prevent nausea and vomiting caused by the chemo drugs docetaxel and cyclophosphamide.
HangzhouAges 18–85 - NCT07208305RecruitingPhase 3
Testing a drug combo for opioid-related nausea
This study tests whether the combination of olanzapine and metoclopramide can prevent nausea and vomiting caused by strong painkillers (opioids) in people with advanced cancer. If you are starting a strong opioid for pain and have not had nausea or vomiting recently, this study may be for you.
Xining, QinghaiAges 18 years+ - NCT07353684RecruitingPhase 2
Adebrelimab plus apatinib with chemo for gastric cancer
This trial tests a combination of two targeted drugs (adebrelimab and apatinib) with standard chemotherapy (SOX regimen) before surgery for gastric cancer that cannot be removed right away. The goal is to shrink the tumor enough to make surgery possible.
Beijing, Beijing MunicipalityAges 18–75 - NCT07716228RecruitingPhase 3
Ear stimulation plus nausea drug for pancreatic cancer chemo
This trial tests if adding a special ear stimulation technique to a standard anti-nausea drug (dexamethasone) works better than the usual treatment alone for nausea and vomiting caused by chemotherapy (gemcitabine plus paclitaxel protein-bound). It is for people with pancreatic cancer who need this chemo.
HangzhouAges 18–85 - NCT06724133Recruiting
Mouth bacteria and colon polyps study
This study looks at the bacteria in your mouth and how they might be linked to colon polyps. Researchers want to see if certain mouth bacteria affect the body's immune system and increase the risk of polyps.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07192978Recruiting
Does activity before surgery affect recovery after hernia repair?
This study looks at whether how active you are before hernia surgery can affect your recovery. It may help doctors give better advice to future patients.
StrasbourgAges 18 years+ - NCT07192575Recruiting
Preventing lung problems after laparoscopic liver surgery
This trial tests if special breathing exercises before surgery can help prevent lung complications after laparoscopic (keyhole) liver surgery. It may benefit you by reducing your risk of pneumonia or other breathing issues after the procedure.
KuopioAges 18 years+ - NCT05125939Recruiting
Testing if one colonoscopy score can replace another
This study looks at whether a colonoscopy “detection score” for overall abnormal growths can stand in for a more specific screening score. It may help improve how screening quality is measured during colonoscopy.
North Hills, CaliforniaAges 50–80 - NCT06173310Recruiting
MRI-guided chemo before surgery for pancreatic cancer
This study tests whether using a special MRI scan to guide chemotherapy can help people with pancreatic cancer that is on the edge of being removable. The goal is to shrink the tumor enough for successful surgery.
Indianapolis, IndianaAges 19 years+ - NCT07532915Recruiting
Two endoscopy methods to prevent stomach vein bleeding
This trial compares two endoscopic (camera-guided) procedures to prevent or treat bleeding from enlarged veins in the stomach. Both approaches aim to stop dangerous bleeding or prevent it from happening in high-risk patients.
Guangzhou, GuangdongAges 18–80 - NCT07696793RecruitingPhase 4
Simethicone colonoscopy prep for cancer screening
This trial tests a colonoscopy preparation drink that contains simethicone (a gas-relief ingredient) to see if it works better than standard prep for people who are already scheduled for a screening colonoscopy after a positive stool test. It may help make the procedure more comfortable and effective.
Barcelona, BarcelonaAges 50–69 - NCT06719596RecruitingPhase 1/Phase 2
Probiotics and nutrition after pancreas surgery
This trial tests whether taking probiotics with a special liquid nutrition feed after pancreatic surgery can lower the chance of getting an infection. If you are scheduled for this surgery, you may be able to join.
Nanjing, JiangsuAges 18 years+ - NCT05828862Recruiting
Checks blood-pressure drops during major upper stomach surgery
This trial studies what happens when blood pressure drops during planned (elective) major upper gastrointestinal surgery and looks at related blood chemistry. Your care team may collect samples during the operation to understand why this happens and how to improve outcomes.
TaipeiAges 20–80 - NCT07186803RecruitingPhase 3
AI and safety in gallbladder removal surgery
This trial studies whether using artificial intelligence (AI) during keyhole gallbladder surgery can make the procedure safer. If you are scheduled for this surgery at University Health Network, you may be able to join.
Toronto, OntarioAges 18 years+ - NCT05133024RecruitingPhase 2
Beetroot juice to help prevent bowel slowdown after colon surgery
This Phase 2 study tests whether drinking beetroot juice can reduce “postoperative ileus,” when the intestines temporarily don’t move normally after colorectal surgery. If it works, it may help you recover bowel function sooner after an elective laparoscopic colon and upper rectum operation.
EdegemAges 18 years+ - NCT07063576RecruitingPhase 2/Phase 3
Baclofen for persistent heartburn or regurgitation
This trial tests whether the drug baclofen can help patients who still have acid reflux symptoms (heartburn or regurgitation) despite taking standard treatments like PPIs for 8 weeks. If you've tried PPIs and still have symptoms, this may be an option.
DhakaAges 18 years+ - NCT07344402Recruiting
Optimizing ear stimulation for chronic constipation
This study tests whether mild electrical stimulation on the ear (called taVNS) can help people with difficult-to-treat constipation. It aims to find the best stimulation schedule to improve bowel movements.
Xi'anAges Any age - NCT06715501Enrolling by invitation
Testing cadonilimab with chemo and radiation for advanced esophageal cancer
This trial tests a new drug (cadonilimab) combined with standard chemotherapy and radiation for people with advanced esophageal squamous cell carcinoma that cannot be surgically removed. The goal is to see if this combination works better than current treatments.
Ningbo, ZhejiangAges 18–75 - NCT06012227Recruiting
Cheese and metabolic health in middle age
This study looks at how eating cheese affects your body's ability to use energy (metabolic flexibility). It is for healthy middle-aged adults who are not overweight and do not have metabolic conditions like diabetes.
Monserrato, CagliariAges 45–65 - NCT07195708Recruiting
Orbera365 Balloon for Weight Loss
This trial tests an intragastric balloon (Orbera365) to help people with obesity lose weight. The balloon is placed in your stomach for up to 12 months. The study will see if it is safe and effective when combined with diet and behavior changes.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07586930Recruiting
Testing a Supplement for Intestinal Health
This study tests whether a daily supplement can help improve gut health and reduce digestive symptoms like bloating, cramping, or irregular bowel habits. You'll undergo simple urine tests to measure how well your intestines are working.
Cork, IrelandAges 18–65 - NCT07196189Recruiting
Fecal transplant for eating disorders
This study tests whether a fecal microbiota transplant (transferring healthy donor stool into your gut) can help treat eating disorders like anorexia, bulimia, or binge eating disorder. It is for women ages 18 to 50 who have not had antibiotics in the last 3 months.
RouenAges 18–50 - NCT07580118Recruiting
Postbiotic Supplement Study for Female Athletes
This study tests whether a postbiotic supplement (a type of gut health product) can reduce digestive problems that female athletes experience during exercise and their menstrual cycle. You'll take the supplement for several months while tracking your symptoms and training.
Liverpool, MerseysideAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.