Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07082673Recruiting
Sea buckthorn supplement for chronic constipation
This study tests a food supplement made from sea buckthorn to see if it helps people with chronic constipation have more regular and comfortable bowel movements.
NaplesAges 18–70 - NCT07060443RecruitingPhase 2
Fluorescent dye study for right-sided colon cancer surgery
This trial tests whether using a fluorescent dye during surgery can help doctors better see and remove lymph nodes in people with right-sided colon cancer. It aims to make surgery more precise and potentially improve outcomes.
DaeguAges 19–85 - NCT07550673RecruitingPhase 4
Upadacitinib vs. Infliximab for Severe Ulcerative Colitis
This study compares two medications—upadacitinib and infliximab—as second-line treatments for acute severe ulcerative colitis (a serious flare of inflammatory bowel disease). The trial will help doctors understand which treatment works better when standard first-line therapy hasn't controlled the inflammation.
Ankang, ShaanxiAges 18–85 - NCT07085299Recruiting
Gut bacteria and recovery in brain artery narrowing
This study looks at how the bacteria in your gut might affect outcomes in people with narrowed brain arteries. Researchers will track your health over time to see if there are links between your gut bacteria and your recovery.
Nanjing, JiangsuAges 30–80 - NCT07085806Recruiting
Pentoxifylline for liver growth after donor surgery
This study tests if a medicine called pentoxifylline can help your liver grow faster after donating a large part of it. You would take the medicine before and after your donor surgery.
New DelhiAges 18–55 - NCT07088757RecruitingPhase 4
Low-Dose vs Standard-Dose Indomethacin for Pancreatitis Prevention After ERCP
This study compares a low dose of indomethacin (a pain reliever) with the standard dose to see if it works just as well for preventing pancreatitis (inflammation of the pancreas) after an ERCP procedure. It may reduce side effects while still protecting your pancreas.
ShanghaiAges 18 years+ - NCT05169398Recruiting
EUS-guided bile drainage with a new metal stent
This trial tests a newer, ultrasound-guided procedure to drain blocked bile flow using a special metal stent. It may help people who have bile duct blockage but could not have their bile drained successfully with standard ERCP.
Hong KongAges 18 years+ - NCT05794971RecruitingPhase 3
Regorafenib with irinotecan beads for colorectal liver spread
This Phase 3 trial tests whether adding a pill called regorafenib to irinotecan “drug-eluting” beads placed in the liver can shrink colorectal cancer that has spread mainly to the liver after standard chemotherapy stops working. If you qualify, it may offer a new combination approach for controlling liver tumors.
Guangdong, GuangzhouAges 18–70 - NCT07110064RecruitingPhase 2
A new combo therapy for advanced pancreatic cancer
This trial tests a combination of three drugs (QL1706, lenvatinib, and chemotherapy) as the first treatment for people with advanced pancreatic cancer that has spread to other parts of the body. It aims to see if this combination is safe and effective.
NanjingAges 18 years+ - NCT07096895Recruiting
Special Endoscopic Procedure for Blocked Bile Duct Access
This trial tests a special endoscopic procedure (EDEE) to reach the bile duct when the usual pathway is blocked, which can happen with certain benign or malignant conditions. If standard methods can't access the area, this approach may offer an alternative.
DüsseldorfAges 18 years+ - NCT07335601RecruitingPhase 2
Resmetirom for liver health after transplant in MASH patients
This trial tests an experimental drug, resmetirom, to see if it can help people who have had a liver transplant for MASH and now have fatty buildup in their new liver. It may also help people who had a transplant for other reasons but developed fatty liver afterward. The study focuses on those with moderate to advanced liver scarring (F2-F3).
La Jolla, CaliforniaAges 18–75 - NCT07715500Recruiting
MRI of Bile Ducts in Living Liver Donors
This study uses an MRI scan to look at the bile ducts in healthy people who want to donate part of their liver. The goal is to see if the scan can help predict and prevent bile duct problems for the person receiving the liver.
New DelhiAges 18–55 - NCT07618884Recruiting
Minimally invasive surgical repair for inguinal hernia
This trial tests a newer surgical technique called TREPP to repair inguinal hernias (bulges in the groin area). The approach may reduce pain and recovery time compared to traditional surgery.
Asyut, Asyut GovernorateAges 18 years+ - NCT07329933Recruiting
Steroids and sedatives for faster recovery after gallbladder surgery
This trial tests if adding two medicines, dexamethasone and dexmedetomidine, helps the stomach and intestines work better after keyhole gallbladder removal. The goal is to see if the combination can get your digestion back to normal faster.
BanhāAges 18–65 - NCT06494514Recruiting
New chemo combo with immunotherapy and radiation for advanced pancreatic cancer
This trial compares two different chemotherapy combinations, each paired with immunotherapy and radiation, as the first treatment for locally advanced pancreatic cancer. It aims to see which combination works better.
Nanjing, JiangsuAges 18 years+ - NCT07300462Enrolling by invitationPhase 4
Oral cholera vaccine safety study for children
This trial is for children aged 2 to 14 who have not had a cholera vaccine before. It tests a safe, oral vaccine to prevent cholera, a serious diarrheal disease.
Hefei, AnhuiAges 2–14 - NCT05201508Recruiting
Sutures versus special mesh for hiatal hernia repair
This study compares two ways of closing tissue during laparoscopic surgery for a severe hiatal hernia. It may help doctors learn which method gives better outcomes and fewer problems after surgery.
OuluAges 18 years+ - NCT07090083Recruiting
Liver health and food support for children
This study tests whether providing fruit and vegetable vouchers to families with children who have fatty liver disease can improve liver health. Diet and lifestyle are key to managing this condition.
San Francisco, CaliforniaAges 6–17 - NCT07549100Recruiting
Tislelizumab plus chemotherapy for advanced esophageal cancer
This trial tests whether combining tislelizumab (an immunotherapy drug) with chemotherapy can shrink advanced esophageal cancer before surgery. The goal is to help patients whose tumors are too large or invasive to operate on initially.
Jinan, ShandongAges 18–75 - NCT07082348Recruiting
Herbs and spices for better diet in college students
This study tests whether adding herbs and spices to your daily meals can help improve your diet quality over a short period. It is designed for college students who feel their eating habits could be healthier.
Las Vegas, NevadaAges 18–39 - NCT07323407Recruiting
Brain stimulation for hard-to-treat constipation with bodily distress
This trial tests if a gentle electrical current applied to the scalp can improve severe constipation in people who also experience persistent physical symptoms (like pain or bloating) that cause high worry. It is for those who have not gotten relief from standard laxatives.
Xi'an, ShaanxiAges 18–80 - NCT05749900RecruitingPhase 1/Phase 2
First-line antibody, chemo, and immunotherapy for HER2 bile duct cancer
This trial studies a combination of trastuzumab (an antibody), gemcitabine and cisplatin (chemo), plus nivolumab (immunotherapy) as the first treatment for advanced HER2-positive biliary tract cancer. It may help shrink tumors and improve outcomes by targeting HER2 and boosting the immune system.
SeoulAges 19 years+ - NCT07527858RecruitingPhase 2
Study of Denikitug with immunotherapy or chemotherapy for advanced colorectal cancer
This trial tests a new drug called denikitug, given alone or combined with other cancer treatments, for patients with advanced colorectal cancer that hasn't responded to previous treatments. The goal is to help people whose cancer has a specific genetic profile (MSS) that doesn't respond well to standard immunotherapy alone.
North Haven, ConnecticutAges 18 years+ - NCT05170503RecruitingPhase 2
Immunotherapy plus chemo before surgery for junction stomach cancers
This Phase 2 study tests giving immunotherapy together with chemotherapy before surgery for certain “locally advanced” cancers at the esophagus-stomach junction. It may help shrink the tumor and improve outcomes by treating the cancer earlier with both immune and chemotherapy approaches.
Guangzhou, GuangdongAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.