Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06208917RecruitingPhase 3
Comparing two ways to give ondansetron for chemo nausea in kids
This trial compares two forms of ondansetron (a nausea medicine) — a dissolving film you put in the mouth versus a needle injection — to see which works better in preventing nausea and vomiting caused by chemotherapy in children with solid tumors.
Guangzhou, GuangdongAges 6 months–18 years - NCT06203600RecruitingPhase 2/Phase 3
Nivolumab plus standard treatment for advanced stomach or esophageal cancer
This trial tests whether adding the immunotherapy drug nivolumab to standard treatment works better for advanced stomach or esophageal cancer. It is for people whose cancer has already progressed after a first round of chemo plus immunotherapy.
Little Rock, ArkansasAges 18 years+ - NCT07229625RecruitingPhase 3
New drug combination for advanced bile duct cancer
This trial is testing whether a new drug (SHR-8068) combined with adebrelimab and chemotherapy works better than the current standard treatment for people with advanced bile duct cancer who have not been treated yet.
Hangzhou, ZhejiangAges 18–75 - NCT07229066Recruiting
Video education for better colonoscopy prep
This study tests whether watching a short educational video can help you prepare better for a colonoscopy. If you haven’t had a colonoscopy before and you or a family member has a smartphone, this study might be for you.
EskişehirAges 18–80 - NCT07642076RecruitingPhase 4
L-carnitine supplement for critically ill liver disease patients
This study tests whether adding L-carnitine (a naturally occurring compound) to standard care helps people with serious liver disease who are in the intensive care unit. L-carnitine may help the body use energy better and reduce complications from liver failure.
MenoufiaAges 18 years+ - NCT07225803Recruiting
Managing pelvic floor muscle problems that cause constipation
This study tests a treatment for a specific type of constipation caused by pelvic floor muscles not working together properly (dyssynergic defecation). It aims to help people who strain or feel blocked when trying to have a bowel movement.
Rochester, MinnesotaAges 18–80 - NCT07050550Recruiting
PET imaging test for people with liver injury
This study tests a new PET imaging agent called ¹⁸F-DFA to see if it can measure liver damage and liver failure. It may help doctors better understand your liver condition using a specialized scan.
Hangzhou, ZhejiangAges 18–80 - NCT06708858RecruitingPhase 2
Studying surufatinib with chemo and immunotherapy for advanced bile duct cancer
This trial tests a combination of a targeted therapy (surufatinib), chemotherapy (gemcitabine and cisplatin), and an immunotherapy (durvalumab or pembrolizumab) for people with advanced bile duct cancer that hasn't been treated with systemic therapy before. The goal is to see if this combination can shrink tumors and improve outcomes.
Beijing, Beijing MunicipalityAges 18–75 - NCT07603336Recruiting
Heart Monitoring Methods During Pancreas Surgery
This study compares two ways of monitoring your heart function during Whipple surgery (pancreas removal). Doctors will use different monitoring approaches to guide fluid and medication during your operation to help you recover better.
Çankaya, AnkaraAges 18–80 - NCT07687940Recruiting
Baduanjin exercise and green tea for mood in older adults
This study tests if doing gentle Baduanjin exercises and drinking green tea together can help improve mood and quality of life in older adults. It also looks at how this program affects gut health.
Kwun TongAges 65–84 - NCT05061732RecruitingPhase 4
Treatment and follow-up study for Helicobacter pylori infection
This trial studies how to eradicate Helicobacter pylori (a germ in the stomach) and monitor follow-up results after treatment. You may be a candidate if you have confirmed infection and have not taken certain stomach medicines or antibiotics recently.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06741904Enrolling by invitation
Predicting liver disease worsening without invasive tests
This study looks at new, non-invasive methods to predict when chronic liver disease might get worse. It could help you and your doctor catch problems early without needing a biopsy or other invasive procedures.
Guangzhou, GuangzhouAges 18–80 - NCT07685652Recruiting
Better prep for colonoscopy with video and booklet
This study tests if watching a short video and reading a booklet helps patients prepare better for a colonoscopy compared to just getting standard instructions. Good preparation makes the procedure safer and more effective.
Sibu, SarawakAges 18 years+ - NCT07537348RecruitingPhase 2
Leucine-restricted diet with chemotherapy for advanced stomach cancer
This study tests whether a special diet low in leucine (an amino acid) combined with chemotherapy and immunotherapy can safely treat advanced stomach cancer that has spread. Researchers want to see if this dietary approach helps the treatment work better and reduces side effects.
Jinan, ShandongAges 18–70 - NCT07625189Recruiting
Registry tracking EUS-guided ablation for pancreatic and digestive lesions
This registry collects information about patients receiving a specialized procedure called EUS-guided ablation—using heat to destroy abnormal growths in the pancreas and digestive tract. By tracking your care, researchers aim to better understand how effective and safe this treatment is.
Morgantown, West VirginiaAges 18 years+ - NCT07610356Recruiting
Understanding gut blood-flow problems in ICU patients
This study helps doctors better predict and understand a serious condition where the bowel doesn't get enough blood flow while patients are in the ICU. By identifying warning signs early, the research aims to improve diagnosis and treatment decisions.
Tallinn, TallinnAges 18 years+ - NCT07537699RecruitingPhase 2
Ear Stimulation and Steroid for Chemo-Related Nausea
This trial tests whether stimulating specific points on your ear, combined with a steroid medication, can reduce nausea and vomiting caused by chemotherapy drugs (docetaxel and cyclophosphamide) given after breast cancer surgery. Many patients experience these side effects, and the study wants to see if this non-drug approach helps.
HangzhouAges 18–85 - NCT06734260RecruitingPhase 3
Optimizing a two-drug therapy for H. pylori infection
This trial tests a two-drug combination (keverprazan and amoxicillin) to see if it works better for treating H. pylori, a bacteria that can cause stomach problems. It is for people who have had H. pylori before and need treatment again.
Guangzhou, GuangdongAges 18–75 - NCT06506786Recruiting
Fresh fruits and vegetables and your gut health
This study looks at how eating fresh garden foods affects the bacteria living in your gut (your microbiome). If you qualify, you may be able to take part in a 3-month study this fall.
Eugene, OregonAges 18–45 - NCT06059378Recruiting
AI helps diagnose small colon polyps during colonoscopy
This trial uses artificial intelligence to help doctors decide if small polyps found during a colonoscopy are harmless. If the AI confirms a polyp is benign, it may be left in place instead of removed, making the procedure simpler and safer for you.
Montreal, QuebecAges 45–80 - NCT07707258Recruiting
Remimazolam with oliceridine for sedation in older adults during GI endoscopy
This trial tests two medicines, remimazolam (a sedative) and oliceridine (a pain reliever), to see if they work well together for sedation during a painless gastrointestinal (GI) endoscopy in people aged 65 to 80. It aims to find a safe and effective option for older adults.
Shanghai, Shanghai MunicipalityAges 65–80 - NCT07213557RecruitingPhase 2
Simvastatin with immunotherapy for ARID1A-mutated stomach cancer
This trial tests whether adding the cholesterol drug simvastatin to standard immunotherapy and chemotherapy can help people with a specific type of gastroesophageal cancer (ARID1A mutated, HER2 negative). It is for patients who have not had prior treatment for advanced disease.
Naples, ItaliaAges 18 years+ - NCT07546097RecruitingPhase 4
Upadacitinib vs Steroids for Severe Ulcerative Colitis
This study compares a newer medication called upadacitinib to traditional steroids for treating acute severe ulcerative colitis (sudden worsening of UC with bloody diarrhea and urgent symptoms). The goal is to see which approach works better as a first treatment.
Ankang, ShaanxiAges 18–85 - NCT07683845Recruiting
Using a tumor model to predict chemo response in pancreatic cancer
This trial tests a personalized approach by growing a miniature model of your tumor from a tissue sample. The goal is to see if this model can predict which chemotherapy will work best for you before you start treatment.
Shanghai, Shanghai MunicipalityAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.