Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1581
- Phase 3465
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer289
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland85
- Ohio79
- Pennsylvania72
Recruiting studies7,879 total
- NCT05680012Recruiting
Testing how gluten affects healing in celiac disease
This study looks at how the gut lining “tissues” are affected during gluten eating versus avoiding gluten in people with celiac disease. It may help researchers understand what drives healing and tissue damage in celiac disease.
Pasadena, CaliforniaAges 18–75 - NCT02361320Recruiting
CT scan study for pancreatic or liver bile cancer
This study looks at how CT scans (detailed X-ray pictures) help diagnose pancreatic cancer or hepatobiliary (liver/bile duct) cancers. It may help your care team better decide what’s going on and plan next treatments.
Houston, TexasAges 18 years+ - NCT07281768RecruitingPhase 2
Chemo and immunotherapy for locally advanced rectal cancer
This trial tests whether adding two types of immunotherapy (cemiplimab with either fianlimab or REGN7075) to standard chemotherapy is safe and effective for people with locally advanced rectal cancer that has not been treated before. It may help shrink the tumor enough to allow surgery that preserves the ability to control bowel movements.
Baltimore, MarylandAges 18 years+ - NCT07219459RecruitingPhase 2
New drug combo for liver cancer after PD-1/PD-L1 treatment fails
This study tests three drugs (visugromab, nivolumab, lenvatinib) compared to a placebo plus lenvatinib for people with liver cancer (HCC) that cannot be removed or has spread, and who have already been treated with a PD-1/PD-L1 inhibitor without success. The goal is to see if the combination can help shrink tumors or slow the cancer.
Los Angeles, CaliforniaAges 18–100 - NCT02595957Recruiting
Study about how people understand genetic test results
This trial studies what people and families think and understand about genetic test results, especially when results suggest a higher risk for disease. It may also include interviews and follow-up, and in some cases additional family testing if it fits the study’s goals.
Bethesda, MarylandAges 1 month–105 years - NCT07511218RecruitingPhase 1
Study of AHB-171 for stable chronic hepatitis B
This trial tests a new investigational drug called AHB-171 for people with chronic hepatitis B who are already stable on standard antiviral therapy. It aims to see if the drug is safe and may help control the virus better.
Ch’ang-ch’un, JilinAges 18–65 - NCT04629677Recruiting
Portal vein stent for narrowed portal blood vessels
This trial looks at whether placing a small metal stent in the portal vein and nearby veins can improve problems caused by major narrowing (or clotting) of these vessels in people with gastrointestinal cancers. If you have significant vessel narrowing, the study may offer a targeted way to relieve pressure and symptoms that are not caused by the tumor directly.
Houston, TexasAges 18 years+ - NCT05835505RecruitingPhase 2
Detox medicine study for primary sclerosing cholangitis
This Phase 2 trial studies a “detoxification” approach to improve liver and bile-duct function in people with primary sclerosing cholangitis (PSC). It may help lower abnormal bile flow markers and see whether the treatment is safe for your liver.
Chestnut Hill, MassachusettsAges 18–75 - NCT07243639Recruiting
Etrasimod for elderly patients with ulcerative colitis
This trial tests an oral medication called etrasimod for elderly patients with active ulcerative colitis. It aims to see if the drug is safe and effective in reducing inflammation and symptoms.
Komagane, NaganoAges Any age - NCT05664113RecruitingPhase 1
Fecal transplant for gut problems after stem cell transplant
This study tests whether transplanting healthy donor stool into the gut can help children and young adults with ongoing digestive issues after a stem cell transplant. It may improve symptoms like diarrhea or the need for feeding tubes.
Memphis, TennesseeAges Up to 22 years - NCT07713433Recruiting
Antibiotics versus none for pediatric colorectal surgery
This trial tests whether giving oral antibiotics before surgery is better than giving no antibiotics for children who are having their colostomy closed or a pull-through procedure. It aims to reduce infections and improve recovery in children with conditions like anorectal malformation or Hirschsprung's disease.
Lahore, Punjab ProvinceAges 1–15 - NCT07715617Recruiting
Creating a prediction score for lung transplant or death in Alpha-1 Antitrypsin Deficiency
This study is creating a simple scoring system to predict who with Alpha-1 Antitrypsin Deficiency-related emphysema might need a lung transplant or die from the disease. Your medical records from 2010–2025 will help build this tool, with no extra tests or visits required.
BronAges 18 years+ - NCT05015296Recruiting
Immune cells and recovery in colorectal cancer surgery
This trial looks at how your immune cells change before and after surgery for colorectal cancer, and whether those changes affect your long-term recovery. It may help doctors predict outcomes and improve care.
Beijing, Beijing MunicipalityAges 18–85 - NCT07713485RecruitingPhase 1
XmAb412 study in healthy adults
This is a first-in-human study testing a new drug called XmAb412 in healthy volunteers. It helps researchers understand how the drug works in the body and if it's safe.
Joondalup, Western AustraliaAges 18–55 - NCT06293898RecruitingPhase 1
Study of BL-M07D1 for HER2-positive solid tumors
This trial tests a new drug, BL-M07D1, for people with advanced solid tumors that have a protein called HER2. It is for patients who have already tried at least two other standard treatments.
Birmingham, AlabamaAges 18 years+ - NCT07714499Recruiting
Energy use in healthy people vs. those with intestinal failure
This study looks at how the body uses energy (calories) in people with intestinal failure compared to healthy controls. The results may help improve nutritional care.
LjubljanaAges 18–65 - NCT07170462RecruitingEarly Phase 1
Cranberry and Gut Health in Crohn's Disease
This trial tests whether taking a daily cranberry supplement can improve gut health and quality of life in people with Crohn's disease. It may help those whose current treatment is stable but still have bothersome symptoms.
Worcester, MassachusettsAges 18–65 - NCT04796818Recruiting
MRI scan to track response in colorectal liver metastases
This study uses a special MRI scan to see how colorectal cancer in the liver responds to planned chemotherapy before and after surgery. It may help doctors better measure treatment success and plan care.
Houston, TexasAges 18 years+ - NCT07692204RecruitingPhase 2
Testing a new drug for advanced stomach cancer
This trial tests a new study drug (SAR445877) for adults with advanced stomach or gastroesophageal junction cancer that has worsened after at least one prior treatment. It aims to find the best dose and see if the drug can help shrink or slow the cancer.
ShanghaiAges 18 years+ - NCT07618377RecruitingPhase 1
New Drug for Gastrointestinal Tumors After Multiple Treatments
This study tests a new drug called DCC-2618 for patients with GIST (a rare stomach/intestinal cancer) who have already tried at least three other treatments. The goal is to see if this drug can slow or shrink tumors in patients whose cancer has stopped responding to standard medications.
Kashiwa, ChibaAges 18 years+ - NCT07710287Recruiting
Using a protein test to measure inflammation in IBD
This study looks at a protein called claudin 2 in tissue samples from people with inflammatory bowel disease (IBD). The goal is to see if it can help doctors tell whether inflammation is active or inactive. This could lead to a more accurate way to check disease activity.
San Donato Milanese, MiAges 18 years+ - NCT06859840Recruiting
Liver tumor detection AI study for cirrhosis patients
This trial tests an AI tool to find and classify liver tumors in people with cirrhosis or extrahepatic cancer who've had a non-contrast CT scan. You may join if you have cirrhosis or a cancer outside the liver, but not if you already have a malignant liver tumor or have had a liver transplant.
Hangzhou, ZhejiangAges 18–90 - NCT06796803RecruitingPhase 2/Phase 3
Combination therapy before surgery for liver cancer
This trial tests a combination of immunotherapy (camrelizumab), a targeted drug (rivoceranib), and liver-directed chemotherapy (HAIC) to shrink liver tumors enough to make them removable with surgery. It is for people with intermediate or advanced liver cancer that has not spread outside the liver.
Harbin, HeilongjiangAges 18–75 - NCT07710885RecruitingPhase 3
Futibatinib for advanced bile duct cancer
This trial tests a new targeted therapy, futibatinib, for people with advanced or unresectable bile duct cancer who have not had prior treatment for advanced disease. It aims to see if this drug can help shrink or control the cancer.
BrisbaneAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,372 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.