Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07505472RecruitingPhase 2/Phase 3
Short radiation plus chemo and immunotherapy for high-risk rectal cancer
This trial tests a new approach for people with locally advanced rectal cancer that has high-risk features. It combines short-course radiation with chemotherapy (CapeOX) and the immunotherapy drug toripalimab, with or without another drug called surufatinib, before surgery. The goal is to see if adding these drugs helps shrink the tumor and improve outcomes.
Changchun, JilinAges 18–75 - NCT07503756RecruitingPhase 2
JS212 Combination for Untreated Metastatic Colorectal Cancer
This trial tests a new drug called JS212 in combination with other medicines for people with metastatic colorectal cancer that has not been treated before. It focuses on patients whose tumors are MSS or pMMR and aims to see if these combinations are safe and effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04615143RecruitingPhase 2
Tislelizumab with or without lenvatinib before liver surgery
This trial studies whether taking tislelizumab alone or with lenvatinib before surgery can shrink recurrent liver cancer and improve outcomes. It may help by treating the cancer earlier (before the tumor is removed).
Guangzhou, GuangdongAges 18–75 - NCT06766643RecruitingPhase 2
Stereotactic radiosurgery vs. radiofrequency ablation for liver cancer
This study compares two nonsurgical procedures for liver cancer: stereotactic radiosurgery (focused radiation) and radiofrequency ablation (heat therapy). It is for people whose tumor is in a tricky spot near major blood vessels or other structures, making surgery difficult, and who have not received prior treatment.
TianjinAges 18–75 - NCT05972655RecruitingPhase 2
Testing shorter rectal radiation with chemotherapy plus immunotherapy
This Phase 2 study tests whether a shorter course of radiation, combined with chemotherapy (CAPOX) and an immunotherapy drug (tislelizumab), can control middle and low rectal cancer. It may also help people who strongly want to keep their anus, if the cancer and overall health fit the study rules.
Hanzhou, ZhejiangAges 18–75 - NCT06767449Recruiting
Zolbetuximab for Claudin18.2 positive stomach cancer
This trial is for people with advanced stomach cancer that has a specific protein called Claudin18.2 and is HER2-negative. It tests whether continuing zolbetuximab—a drug that targets this protein—can help control the cancer.
SeoulAges 19 years+ - NCT06765616RecruitingPhase 2
Immunotherapy with chemo and radiation for rectal cancer before surgery
This trial tests a combination of a PD-L1 inhibitor (adebrelimab), short-course radiation, and chemotherapy given before surgery for locally advanced rectal cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
Jinan, ShandongAges 18–85 - NCT06556940RecruitingEarly Phase 1
Study of LMN-401 in people with an ileostomy
This study looks at how your body absorbs the drug LMN-401 when you have an ileostomy. It's designed to understand the effect of your digestive system on the medicine.
MaroochydoreAges 19 years+ - NCT06765252Recruiting
How gene differences affect capecitabine side effects
This study looks at how genetic differences in Egyptian people with breast or colorectal cancer might affect the side effects of the chemotherapy drug capecitabine. The goal is to understand why some people have more side effects than others.
Shibīn al Kawm, MenoufiaAges 18 years+ - NCT06767436Recruiting
Real-world study of Enhertu for advanced gastric cancer
This study looks at how well the drug Trastuzumab Deruxtecan works and how safe it is in real-world patients with advanced stomach or gastroesophageal cancer whose tumors are HER2-positive. The goal is to gather more information beyond what was learned in clinical trials.
Seoul, SeoulAges 19 years+ - NCT07496723Recruiting
Comparing diagnostic methods for appendicitis surgery
This trial looks at whether different ways of diagnosing appendicitis (like CT scans) are accurate. It's for people who already had surgery to remove their appendix and want to help doctors learn more.
Sanliurfa, ŞanlıurfaAges 18 years+ - NCT07493421Recruiting
Surgery and heated chemotherapy for pancreatic cancer with spread to the abdomen
This trial tests if combining surgery to remove the tumor with a special heated chemotherapy bath for the abdomen (HIPEC) is safe and possible for people whose pancreatic cancer has spread only to the lining of the abdomen.
Shanghai, shangaiShanghai MunicipalityAges 18 years+ - NCT06422403RecruitingPhase 2
Study on giving immunotherapy less often for advanced cancer
This trial tests whether giving certain immunotherapy drugs less often than usual is safe and still works well for people with advanced stomach, liver, or lung cancer. It might mean fewer hospital visits while still controlling the cancer.
SingaporeAges 21–99 - NCT06122285Recruiting
Bulevirtide for chronic hepatitis delta
This study tests a daily shot of Bulevirtide for people with long-term hepatitis delta and early-stage cirrhosis. It aims to see if the medicine is safe and works well.
Milan, MIAges 18 years+ - NCT05576038Recruiting
Tryptophan to help celiac symptoms improve
This trial tests whether tryptophan (a natural amino acid) can improve symptoms in people with celiac disease who still have symptoms despite following a gluten-free diet. It may help by supporting an internal body signal pathway researchers believe is impaired in some people with celiac disease.
Hamilton, OntarioAges 18–75 - NCT06767579Recruiting
Comparing Delirium Risk After Liver Transplant: Inhaled vs. IV Anesthesia
This study compares how often confusion (delirium) happens after liver transplant when using two different anesthesia medicines: sevoflurane (inhaled gas) versus propofol (IV medicine). It helps doctors find out which anesthesia might be safer for your brain.
SeoulAges 19 years+ - NCT06572813RecruitingPhase 1/Phase 2
Combination therapy for advanced pancreatic cancer
This trial tests whether adding bortezomib and an immunotherapy drug to standard chemotherapy can help people with pancreatic cancer that has spread to other organs. It is for patients who have not had treatment or whose cancer has worsened after gemcitabine-based chemotherapy.
Hangzhou, ZhejiangAges 18–75 - NCT06767605Recruiting
Spanish registry for autoimmune liver diseases
This study collects information from people with autoimmune or cholestatic liver diseases to better understand them and improve care. It does not test a new treatment, but your participation can help future research.
BarcelonaAges 18 years+ - NCT07494318Recruiting
GI surgery training study for senior residents
This study looks at how advanced gastrointestinal surgery training is done for senior general surgery residents. It compares training for fourth- and fifth-year residents in accredited programs across the United States.
Dallas, TexasAges Any age - NCT07494968Recruiting
Finding ways to track diet compliance in IBS patients
This study looks for signs in your body—like breath and blood tests—that can show how well you are following a special diet for IBS. It aims to find better ways to track diet compliance, which could help make dietary treatments more effective.
Ann Arbor, MichiganAges 18–65 - NCT07494201Recruiting
MIMICC study for people with colorectal cancer
This trial is studying patients with colorectal cancer who are scheduled for surgery. Researchers want to learn more about the cancer to improve future treatments.
Candiolo, Torino (TO)Ages 18–75 - NCT07495735Recruiting
Predicting response to liver cancer treatment
This study is looking at how well a combination of two drugs (atezolizumab and bevacizumab) works for people with liver cancer that can't be removed by surgery. The goal is to learn how to predict the best response using lab tests and CT scans.
Wenzhou, ZhejiangAges 18 years+ - NCT07491848Recruiting
Mouth health study for hepatitis B and D patients
This study looks at mouth health in people with hepatitis B and D, including those taking a medicine called bulevirtide and those not taking it. It may help understand how these infections affect the mouth and gums.
CraiovaAges 18 years+ - NCT07493876Recruiting
Enhanced recovery after surgery for peritoneal cancer
This trial tests a special recovery program after surgery for cancer that has spread to the lining of the belly. The program aims to help you heal faster and feel better after the procedure.
Candiolo, TurinAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.