Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07510347Recruiting
Pain relief study for sleeve gastrectomy patients
This study tests if giving pain medicine in a different area of the abdomen can reduce pain after weight-loss surgery. It may help you feel more comfortable after your sleeve gastrectomy.
Shibīn al Kawm, MenofiaAges 20–60 - NCT07510308RecruitingPhase 1
Vaccine trial for advanced colorectal cancer
This trial tests a personalized vaccine made from your own tumor cells for advanced colorectal cancer that is mismatch repair proficient (pMMR). It aims to see if the vaccine can help when standard treatments have stopped working.
Chengdu, SichuanAges 18–75 - NCT07511244Recruiting
Spinal cord stimulation for bladder and bowel control after spinal cord injury
This trial tests whether spinal cord stimulation can help improve bladder and bowel function in people who have had a spinal cord injury for more than 6 months. The goal is to see if this treatment can restore more control and quality of life.
BeijingAges 18–60 - NCT07513038RecruitingPhase 1/Phase 2
Using dye imaging to diagnose bile duct blockage in infants
This trial tests whether a special fluorescent dye called indocyanine green (ICG) can help doctors better diagnose biliary atresia—a rare condition where a baby's bile ducts don't form properly. The dye is used during an imaging scan to light up the bile system so doctors can see it more clearly.
Boston, MassachusettsAges birth–3 months - NCT07512232Recruiting
Rectal Lavage During Surgery to Lower Cancer Recurrence Risk
This trial tests whether rinsing the rectum with special fluid during minimally invasive surgery for mid-to-low rectal cancer helps prevent the cancer from coming back locally. The procedure aims to wash away cancer cells that might have leaked into the surgical area.
Guangzhou, GuangdongAges 18–75 - NCT07512934Recruiting
Pancreatic Function Study in Early Type 2 Diabetes
This study examines how the pancreas works in people newly diagnosed with type 2 diabetes. Researchers will assess pancreatic function to better understand early diabetes and potentially improve treatment.
Aktobe, AktobeAges 18–74 - NCT07510191RecruitingPhase 4
Comparing two ways to treat Crohn's disease if TNFi isn't working well
This trial tests if adding a low dose of a newer pill (upadacitinib) to your current TNF inhibitor (TNFi) works better than increasing the dose of your TNFi alone. It is for people with Crohn's disease who have had some improvement on their TNFi but still have active disease.
Guangzhou, GuangdongAges 18–65 - NCT07507643RecruitingPhase 3
Steroid treatment before liver surgery study
This study tests if a steroid called methylprednisolone can help people recovering from major liver surgery. It aims to see if it reduces inflammation and improves outcomes.
Chicago, IllinoisAges 18 years+ - NCT07510321Recruiting
A study of FL-261 imaging for cancer diagnosis
This trial tests a new imaging agent called FL-261 to help doctors see and stage cancers more clearly. If you have a known or suspected cancer like lung, colon, or head and neck cancer, this study may improve how your cancer is evaluated.
Wuhan, HubeiAges 18 years+ - NCT07508930Recruiting
Russian extreme high triglycerides registry
This study creates a registry for people with very high triglycerides (≥10 mmol/L). It aims to understand who gets this condition and how it affects them over time.
AstrakhanAges Any age - NCT05919680RecruitingPhase 2
NST-6179 for liver disease from intestinal failure in adults
This Phase 2 study tests NST-6179 in people who have intestinal failure–associated liver disease (IFALD). It aims to improve liver function and overall outcomes for people whose liver inflammation and lab tests have been abnormal for at least 6 months.
Scottsdale, ArizonaAges 16 years+ - NCT06625957RecruitingPhase 3
NTCB02-1 trial for patients needing IV nutrition
This trial tests an investigational IV nutrition product called NTCB02-1 in patients who need nutrition through a vein (parenteral nutrition) for at least 3 days. It aims to see if it is safe and works well.
Gyeonggi-do, Goyang-siAges 19 years+ - NCT06760858Recruiting
Study of treatment for advanced stomach cancer
This study tests a treatment approach for stomach cancer that hasn't spread to other organs. It's for people who have not had any prior cancer treatments and are in relatively good health.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT06761027RecruitingPhase 1/Phase 2
Three-drug chemo plus targeted and immune therapy for advanced pancreatic cancer
This trial tests a combination of three chemotherapy drugs (mFOLFIRINOX) along with anlotinib (a targeted therapy) and sintilimab (an immunotherapy) for people with advanced pancreatic cancer who have not had prior treatment. The goal is to see if this combination can help shrink tumors or slow the disease.
Fuzhou, FujianAges 18–75 - NCT06761261Recruiting
Acute Hepatitis in Children Study
This trial is for children and teens (0–17 years) who are in the hospital or emergency department with acute hepatitis (sudden liver inflammation). The study aims to learn more about the condition and how to best treat it.
BolognaAges Up to 17 years - NCT06761209Recruiting
Autoantibody negativity and autoimmune hepatitis severity
This trial checks if the absence of certain antibodies in autoimmune hepatitis (AIH) is linked to more severe disease. It may help doctors better understand and treat AIH.
Paris, FranceAges 18 years+ - NCT07500259Recruiting
Personalized drug testing for GI tumors
This trial uses a lab test to see how your tumor responds to different drugs, helping doctors choose the best treatment for you. It is for people with pancreatic cancer (PDAC) who are having surgery or a biopsy.
Luxembourg, LuxembourgAges 18 years+ - NCT07503808RecruitingPhase 1
IDE034 for advanced solid tumors with B7-H3 or PTK7
This study tests a new drug called IDE034 for people with advanced solid tumors that have certain markers (B7-H3 and PTK7). The drug may help by targeting these markers on cancer cells, and the study checks if it is safe and effective.
Denver, ColoradoAges 18 years+ - NCT07499258Recruiting
Axonics R20 study for fecal incontinence
This trial is testing how well a device called Axonics R20 works for people with fecal incontinence. It may help if you have this condition and are willing to follow the study procedures.
New York, New YorkAges 18 years+ - NCT07499232RecruitingPhase 3
Guselkumab vs Risankizumab for Crohn's disease
This trial compares two drugs, guselkumab and risankizumab, to see which works better for people with moderate-to-severe Crohn's disease. Both are given as injections and aim to reduce inflammation in the gut.
Dothan, AlabamaAges 18 years+ - NCT07500220RecruitingPhase 1/Phase 2
Dual-target CAR-NK cell therapy for advanced liver cancer
This trial tests a new cell therapy made from natural killer (NK) cells that are engineered to attack two targets (GPC3 and B7-H3) found on liver cancer cells. It may be an option for people with advanced liver cancer who have already tried standard treatments.
Shenzhen, GuangdongAges 18–75 - NCT07505797Recruiting
Ultrasound imaging study for suspicious breast lesions
This study is testing a new ultrasound device (ATUSA) to see how well it can image breast lesions that have been classified as suspicious (BI-RADS 4 or 5). If you have a recent finding that needs further evaluation, this research might help improve detection methods.
Sacramento, CaliforniaAges 18–94 - NCT07499544RecruitingPhase 3
Testing Libevitug for chronic hepatitis D
This study tests a new drug, Libevitug, for people with chronic hepatitis D (HDV). It aims to see if the drug can help control the virus and improve liver health.
Garden Grove, CaliforniaAges 12–70 - NCT07505030Enrolling by invitationPhase 1
Safety study of LYNC-101 in healthy adults
This trial tests a new medicine called LYNC-101 in healthy volunteers to see if it is safe and how the body processes it. If you are a generally healthy adult between 18 and 60, you may be able to help researchers learn about this potential treatment.
Adelaide, South AustraliaAges 3 weeks–2 months
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.