Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT06307314Recruiting
Can SAA1 predict mouth sores from radiation therapy?
This study is looking at a blood marker called SAA1 to see if it can predict how severe mouth sores (oral mucositis) will be after radiation therapy. If you have head and neck cancer and are about to get radiation, this trial may help answer questions about side effects.
Guangzhou, GuangdongAges 18 years+ - NCT06306846RecruitingPhase 2
Radiation and immunotherapy before surgery for head and neck cancer
This study tests giving a short course of targeted radiation (SBRT) along with immunotherapy and a targeted drug before surgery for advanced head and neck cancer. The goal is to see if this combination can shrink the tumor and improve outcomes.
Hangzhou, ZhejiangAges 18–70 - NCT06308328Recruiting
Mucosal contouring study for oral pain from radiation
This study tests a new way to reduce mouth and throat pain caused by radiation therapy for nasopharyngeal cancer. It may help if you are currently getting radiation or chemoradiation and have mouth sores.
Guangzhou, GuangdongAges 18 years+ - NCT06313450Recruiting
Lower radiation for nose cancer after immunotherapy and chemo
This trial tests whether giving a lower dose of radiation to the main tumor is safe and effective for people with nasopharyngeal cancer (a type of nose/throat cancer) who first receive a combination of immunotherapy (toripalimab) and chemotherapy. It aims to reduce side effects while still controlling the cancer.
Guangzhou, GuangdongAges 18–70 - NCT06321939Recruiting
Tracking EBV DNA in Blood for Nasopharyngeal Cancer
This trial studies whether tracking levels of Epstein-Barr virus DNA in your blood can help guide treatment for non-metastatic nasopharyngeal cancer. You would get standard radiation and maybe chemotherapy, with extra blood tests to see how the virus levels change.
Changsha, HunanAges 18 years+ - NCT06129552Recruiting
Healthy nose cells study for sinusitis insight
This study is looking at healthy people to understand how certain cells in the nose work. It will compare them to people with sinus problems to learn what goes wrong in chronic sinusitis with nasal polyps.
LeuvenAges 18 years+ - NCT05938972Recruiting
Study of biologic medicines in severe CRSwNP patients
This study looks at how “biologic” medicines work in real-life care for people with severe chronic rhinosinusitis with nasal polyps (CRSwNP). It may help confirm which patients benefit and how treatment is used in everyday practice.
GhentAges 18–80 - NCT06364670Recruiting
Acupuncture for tinnitus: brain imaging study
This study is testing whether acupuncture can help treat tinnitus by using a special brain imaging technique (fNIRS) to see how the brain responds. It may help find out who benefits most from acupuncture.
Hangzhou, ZhejiangAges 18–60 - NCT06151743RecruitingPhase 2
Testing drug combo before throat cancer surgery
This trial tests a new combination of drugs (an immunotherapy called a PD-1 inhibitor, cetuximab, and platinum chemotherapy) given before surgery for advanced throat cancer that requires removing the voice box. The goal is to see if this treatment shrinks the tumor and improves outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06282497Recruiting
New radiation technique to reduce dry mouth in nasopharyngeal cancer
This trial compares a new radiation technique designed to reduce dry mouth (xerostomia) with standard radiation for people with nasopharyngeal cancer. It aims to see if the new approach can protect saliva glands while still treating the cancer effectively.
Zhongshan, GuangdongAges 18–70 - NCT06395298Recruiting
Mouth care therapy for premature babies' feeding
This study tests a gentle mouth care routine called PIOMI to help very premature babies (born at 29–30 weeks) learn to feed by mouth. It’s for babies who need a feeding tube but are otherwise stable.
Barcelona, CataloniaAges 7 months–7 months - NCT03914378Recruiting
Study how radiation and cisplatin affect hearing in head and neck cancer
This study looks at how radiotherapy, and possibly cisplatin chemotherapy, affect hearing in people treated for head and neck cancer. It may help doctors better predict hearing side effects and plan hearing monitoring or prevention.
ManchesterAges 18 years+ - NCT06019130RecruitingPhase 2
Nivolumab for newly diagnosed nasopharyngeal cancer
This trial tests whether the immunotherapy drug nivolumab (Opdivo) can help treat nasopharyngeal cancer in both children and adults. It is for people who have just been diagnosed and have not yet received any cancer treatment.
AachenAges 3 years+ - NCT04444869RecruitingPhase 2
Lower-dose radiation with chemotherapy for low-risk HPV throat cancer
This trial tests whether a less intense (lower-dose) radiation plan, combined with chemotherapy, can control HPV-positive oropharyngeal (throat) cancer with fewer side effects. It targets people considered “low-risk” based on tumor size and lymph node involvement.
Columbia, MissouriAges 18 years+ - NCT07851857RecruitingPhase 3
Short course of antibiotics after head and neck cancer surgery
This trial tests whether giving antibiotics for one day after head and neck surgery works just as well as giving them for longer to prevent infections. It might help you have a smoother recovery with fewer side effects from antibiotics.
São Paulo, São PauloAges 18 years+ - NCT07852624Recruiting
Anesthesia during planned c-section and newborn hearing
This study compares two types of anesthesia used during planned cesarean deliveries to see if they affect the baby's hearing after birth. If you qualify, you would receive one of the standard anesthesia methods, and your baby's hearing would be checked shortly after delivery.
WenzhouAges 18–35 - NCT06439290Recruiting
Voice Changes After Vocal Cord Surgery
This study looks at how different types of voice surgery affect the voice. Researchers will record and analyze voices before and after surgery to understand the results better.
Ghent, East-FlandersAges 18–70 - NCT07846345Recruiting
Case management support for ear reconstruction in microtia
This study looks at whether extra support and coordination (case management) can help people going through ear reconstruction for microtia. If you're planning this surgery, the study may help you understand and manage the process better.
ShanghaiAges 6–40 - NCT06362122Recruiting
Severe nasal polyps: links between symptoms, tissue, and blood
This study looks at people with severe nasal polyps that need surgery (ethmoidectomy) for the first time. Researchers want to understand the connection between your symptoms, nasal tissue, and blood tests.
PoitiersAges 18 years+ - NCT07838051Recruiting
Muscle relaxants for sore throat after breathing tube
This study tests whether giving muscle relaxants during surgery can reduce sore throat after using a special breathing tube called a video laryngeal mask airway. It may help people who are having longer surgeries and have a higher body mass index.
Samsun, SamsunAges 18–70 - NCT06464757Recruiting
Laryngomalacia and breathing in children: before and after treatment study
This trial is for children with laryngomalacia (a floppy voice box) who have noisy breathing and trouble breathing. It will check how they are doing before and after treatment, and follow up for one year to see how their quality of life improves.
OsloAges 1 week–12 months - NCT07831876RecruitingPhase 1
Ear nerve stimulation for eye inflammation
This study tests whether gently stimulating a nerve in the ear can help reduce swelling or irritation in the eyes. It may offer a new drug-free way to treat certain types of eye inflammation.
Basking Ridge, New JerseyAges 18 years+ - NCT06455410RecruitingPhase 2
GP plus adebrelimab vs. chemo alone for nasopharyngeal cancer
This trial tests a new combination of chemotherapy drugs (GP) plus an immunotherapy drug (adebrelimab) before standard treatment for nasopharyngeal cancer. It aims to see if this combination works better than chemotherapy alone for shrinking tumors.
Foshan, GuangdongAges 18–65 - NCT06445088Recruiting
Testing a new EBV DNA test for nasopharyngeal cancer
This trial is testing a new way to diagnose nasopharyngeal cancer using a special test that looks at a change in the EBV virus DNA. It is for people who may have symptoms of this cancer or have tested positive for EBV, but have not yet been treated.
Fuzhou, FujianAges Any age
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.