Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT07819656Recruiting
Predicting severe blood cell drops in nasopharyngeal cancer
This study looks at how likely it is for people with nasopharyngeal carcinoma to experience a severe drop in blood cell counts (myelosuppression) during treatment. By tracking risk, doctors may be better able to prevent or manage this side effect.
Guangzhou, GuangdongAges 18 years+ - NCT06301165RecruitingPhase 2
Chemotherapy comparison for advanced nasopharyngeal cancer
This trial compares two different chemotherapy combinations given before radiation for nasopharyngeal cancer. It is for patients with advanced but not metastatic disease who are in good overall health.
Guangzhou, GuangdongAges 18–65 - NCT06490029Recruiting
Hearing loss from cancer treatment: a diagnosis study
This study looks at hearing problems caused by cancer treatments that can damage the ears or nervous system. It aims to better understand and diagnose these side effects to help patients.
ParisAges 18 years+ - NCT06490237Recruiting
Studying hearing nerve signals during brain surgery
This study records how the hearing nerve responds to speech sounds during planned brain surgery. It aims to understand hearing loss better and may help improve future treatments.
ReimsAges 18 years+ - NCT07810374Enrolling by invitation
Learning program for swallowing difficulties after stroke
This trial tests an interactive teaching system that helps stroke patients learn about swallowing difficulties (dysphagia). The program uses videos and quizzes to teach you techniques to swallow safely, which might help you recover and avoid complications.
Yuli, Yilan CountyAges 20–75 - NCT07814924RecruitingPhase 4
Mepolizumab plus in-office polyp removal for chronic sinusitis
This study tests whether combining mepolizumab (a biologic injection) with a quick in-office removal of nasal polyps improves symptoms better than usual care. It is for adults with chronic sinusitis and nasal polyps who qualify for biologic therapy.
BarakaldoAges 18–80 - NCT06499584Recruiting
How the Inner Ear Responds to Voices During Brain Surgery
This study looks at how the inner ear responds to human voices during brain surgery. It may help doctors understand hearing better and improve treatments for hearing loss.
ReimsAges 18–80 - NCT06383780RecruitingPhase 3
Tislelizumab plus chemo for nasopharyngeal cancer with bone spread
This trial tests a combination of the immunotherapy drug tislelizumab with chemotherapy for people whose nasopharyngeal cancer has spread to the bones. It may be an option if you have not had prior treatment for advanced disease.
Guangzhou, GuangdongAges 18 years+ - NCT06438627RecruitingPhase 3
New triple therapy vs standard for advanced nasopharyngeal cancer
This trial tests a new combination of three drugs (TPC, apatinib, and camrelizumab) against the standard two-drug regimen (GP plus camrelizumab) for people with high-risk nasopharyngeal carcinoma that has spread to neck lymph nodes. The goal is to see if the three-drug combination works better and is safe.
Guangzhou, GuangdongAges 18–65 - NCT07807163RecruitingPhase 2
Study of ficerafusp alfa with pembrolizumab for head and neck cancer
This study tests a new drug called ficerafusp alfa combined with pembrolizumab (an immunotherapy) in people with head and neck cancer that has returned or spread. The drug targets a protein that may help the immune system fight the cancer. The study is comparing two different schedules of giving the drug to see which is better.
Fort Myers, FloridaAges 18 years+ - NCT06505330Recruiting
Probiotics for kids with cleft palate
This study looks at whether giving probiotics (helpful bacteria) to children with cleft palate can improve the bacteria in their airways and possibly prevent infections. Researchers want to see if this simple treatment helps keep kids healthier.
Edegem, AntwerpAges 6 months–2 years - NCT07801625Recruiting
How eyes and nose react to grass allergy
This study looks at how people with and without grass allergies react when a small amount of grass allergen is put into the eye. It aims to understand the immune response in the eyes and nose, which may help improve allergy treatments.
Kingston, OntarioAges 18–70 - NCT05935683Recruiting
Registry for severe, uncontrolled chronic sinusitis in Italy
This trial is a registry that enrolls people with severe, hard-to-control chronic sinusitis. It helps doctors better understand this specific type of inflammation and how it affects symptoms and quality of life.
Rozzano, MIlanAges 18 years+ - NCT06511284Recruiting
Nutrition therapy for swallowing problems after breathing tube removal
This study tests whether specialized nutrition therapy can help patients who have trouble swallowing after a breathing tube is removed. The goal is to improve recovery and quality of life for people who need a feeding tube after leaving the hospital.
Mexico CityAges 18 years+ - NCT05915078Recruiting
In-office ear tube care with a specific device
This registry study follows children who get ear tubes placed in the doctor’s office using the Tula system. It aims to track outcomes, such as how well the tubes work and how patients do afterward.
Louisville, KentuckyAges 6 months–17 years - NCT06516133RecruitingPhase 3
Online adaptive radiotherapy for nasopharyngeal cancer
This trial tests a new type of radiation therapy that adjusts in real-time to treat nasopharyngeal cancer. It is for people who have not received prior radiation and have no distant spread of cancer.
Guangzhou, GuangdongAges 18–70 - NCT06523478Recruiting
Tonsil injection allergy shots for hay fever
This trial tests a new way to treat allergies by injecting allergy medicine directly into the tonsils. It may help people with hay fever who haven't gotten relief from standard treatments or want to avoid long-term medication.
Wuhan, HubeiAges 5–65 - NCT07796139Recruiting
Nasal dilator therapy for eustachian tube dysfunction
This study tests whether using a nasal dilator (a small device that opens the nostrils) can help with symptoms of patulous eustachian tube dysfunction, a condition where the tube in the ear stays open too much. If you have this condition, this treatment might reduce symptoms like ear fullness or hearing your own voice too loudly.
Houston, TexasAges 18 years+ - NCT07793799Enrolling by invitation
Comparing brain stimulation treatments for swallowing problems after stroke
This study tests three non-invasive brain stimulation methods to see if they can help improve swallowing after a stroke. If you have swallowing difficulties due to a stroke, this research might offer a new way to support your recovery.
IstanbulAges 18 years+ - NCT07798297Recruiting
Sound sensitivity therapy for autistic adults
This trial tests a therapy designed to help autistic adults who are very sensitive to everyday sounds. The treatment aims to make loud sounds more comfortable and improve daily life.
Orlando, FloridaAges 18–39 - NCT07798401RecruitingPhase 2
Tongue training device for swallowing problems after stroke
This study tests a special tongue-training device that gives you feedback to help improve swallowing after a stroke or similar condition. It uses a computer and a small sensor in your mouth to guide your exercises.
Foshan, GuangdongAges 18–80 - NCT07795294Recruiting
Swallowing exercises for head and neck cancer patients
This trial tests a swallowing exercise program for people getting chemoradiotherapy for head and neck cancer. The goal is to help you swallow better and reduce side effects from treatment.
CairoAges 20–60 - NCT06529562Recruiting
Surgery plus reduced chemo and radiation vs standard for nasopharyngeal cancer
This trial compares two approaches for people with early-stage nasopharyngeal cancer that can be removed with surgery. It tests whether giving less intense chemotherapy and radiation after surgery works as well as a standard dose, with fewer side effects.
Zhuhai, GuangdongAges 18–70 - NCT06533267Recruiting
Endoscopic surgery vs. radiation for early-stage nasal cancer
This trial compares two treatments for stage I nasopharyngeal cancer (a type of nasal cancer). It tests whether a minimally invasive surgery (endoscopic surgery) is as good as or better than radiation therapy. It may be an option for people whose cancer is small and hasn't spread to lymph nodes.
Zhuhai, GuangdongAges 18–75
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.