Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT06123221Recruiting
Sinus lift study: comparing two dental implant techniques
This study compares two methods for lifting the sinus floor to place dental implants. It is for people who need an implant in the upper jaw but don't have enough bone height. The goal is to see which technique works better.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT04685746Recruiting
Testing how balance and motion affect child development
This study looks at how the vestibular system (your balance and motion sensing) is involved in children’s thinking and movement. It compares typically developing children with children who have balance-related (vestibular) problems or certain neurodevelopmental conditions to understand what to expect and how development may differ.
GhentAges 6–13 - NCT03240965Recruiting
Testing changes in smell and taste after recent stroke
This study looks at how smell and taste may change after a new stroke, especially in the first few days. It may help doctors better understand and monitor symptoms related to eating and swallowing after stroke.
Giessen, HesseAges 18 years+ - NCT05851508RecruitingPhase 3
Steroid ear injections for vertigo in one-ear Ménière’s
This Phase 3 study compares injections of steroid medicine into the ear versus a dummy (placebo) injection to see if it reduces vertigo attacks in people with Ménière’s disease. It may help by improving balance symptoms and reducing how often attacks happen.
Leiden, South HollandAges 18–100 - NCT06161779Recruiting
Reconstructing the hypopharynx after cancer removal
This trial tests a surgical technique using a flap from under your chin to rebuild the hypopharynx after removing cancer. It may help people with hypopharyngeal cancer that has not spread far and who have not had radiation before.
Guangzhou, GuangdongAges 18–80 - NCT06167109Recruiting
NBI and MRI to guide radiation planning for one-sided nose cancer
This trial tests whether combining a special scope (NBI) with MRI scans can help doctors better target radiation therapy for a specific type of nose/throat cancer that affects only one side. It aims to make treatment more precise and reduce side effects.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06001047Recruiting
Head acupuncture for BPPV residual symptoms
This study tests whether head acupuncture can help with lingering symptoms (like unsteadiness or discomfort) that sometimes remain after a successful repositioning procedure for BPPV, a common cause of vertigo. If you feel better but not fully steady, this treatment might help.
Xi'anAges 18–65 - NCT06092957RecruitingPhase 3
Reduced radiation after chemo-immunotherapy for high-risk nasopharyngeal cancer
This trial tests whether a lower dose of radiation, with or without additional chemo-immunotherapy, works as well as the standard full-dose chemoradiation for people with advanced nasopharyngeal cancer who had a complete response after initial chemo-immunotherapy.
Guangzhou, GuangdongAges 18–70 - NCT07860580Recruiting
Blood markers in children with congenital hearing loss
This study looks at certain substances in the blood of children with congenital hearing loss (hearing loss present from birth) to see if they are different from children with normal hearing. It may help doctors understand why hearing loss happens and could lead to better treatments.
SanliurfaAges Up to 17 years - NCT05670158Recruiting
Testing blood immune markers after cochlear implantation
This study compares blood and fluid-related immune “profiles” after cochlear implant surgery versus another ear/middle-ear surgery group. It aims to learn which immune signals may be linked to hearing outcomes and recovery after implantation.
MontpellierAges 18 years+ - NCT07860411Recruiting
Biomarker study for chronic sinusitis with nasal polyps
This study looks for certain markers in your blood and nasal tissue that may be linked to chronic sinusitis with nasal polyps. It may help doctors understand the condition better and could lead to more targeted treatments in the future.
SanliurfaAges 18 years+ - NCT06240689RecruitingPhase 2
Immune maintenance therapy after chemoradiotherapy for head and neck cancer
This trial tests whether adding an immune checkpoint inhibitor (a drug that helps your immune system fight cancer) as maintenance therapy after chemoradiotherapy improves outcomes for people with locally advanced head and neck cancer. It specifically looks at a marker in your blood (CD8Tex cells) to see if you might benefit.
Hangzhou, ZhejiangAges 18–75 - NCT06241599RecruitingPhase 2/Phase 3
AK104 with chemo for advanced nasopharyngeal cancer
This study tests if adding a new immunotherapy drug (called AK104) to standard chemotherapy can help people whose nasopharyngeal cancer has come back or spread after previous treatment. The goal is to see if the combination works better than chemotherapy alone.
Guangzhou, GuangdongAges 18–75 - NCT04471493Recruiting
Study of children’s common infections in a clinic program
This trial is for children under 16 who have one of several common infections seen in outpatient or clinic visits. It aims to better study and manage these illnesses using a specific clinical documentation software.
CréteilAges 1 day–16 years - NCT06182657Recruiting
Nasopharyngeal cancer response to induction chemotherapy
This study looks at how well nasopharyngeal cancer (NPC) responds to the first round of chemotherapy before other treatments. It aims to see if the amount of tumor shrinkage can help predict outcomes and guide future care for people with advanced NPC.
Nanchang, JiangxiAges 18 years+ - NCT02630589Recruiting
Brain implant for severe one-sided ringing that harms daily life
This trial tests an implant that sends sound signals to the brainstem to reduce severe ringing in one ear. It may help people whose one-sided tinnitus has lasted over a year and did not improve with usual treatments like hearing aids and CBT.
GroningenAges 18 years+ - NCT04547673Recruiting
Test an endoscopy camera tool to help diagnose throat cancer
This study checks an “intelligent” camera used during a nose-and-throat exam to improve how nasopharyngeal cancer is diagnosed. If you are eligible, your care team will compare how well the tool identifies the condition.
Guangzhou, GuangdongAges 18 years+ - NCT07867223Recruiting
Fungal ear infection treatment: plum extract vs clotrimazole
This study tests whether a new ear drop made from plum extract is as good as the standard antifungal treatment for fungal ear infections. You would use the drops for a certain time to see if the infection clears up.
MinyaAges 16–80 - NCT07857655RecruitingPhase 4
Intraoperative methadone for pain after head and neck cancer surgery
This trial tests whether giving methadone during your head and neck cancer surgery helps control pain right after the operation. Methadone is a long-acting painkiller that might reduce pain for up to a day or more, potentially improving your recovery experience.
Portland, OregonAges 18–89 - NCT07853872Recruiting
Cheek flap surgery for speech problems after cleft palate
This study looks at how using tissue from the cheek to help close the gap in the roof of the mouth affects the cheek and the muscle used for chewing. It aims to see if this surgery is safe and effective for improving speech.
SohagAges 18 years+ - NCT06287788Recruiting
Mouth soreness trial for nasopharyngeal cancer patients
This trial tests a new way to map mouth and throat sores caused by radiation therapy. It focuses on pain when swallowing to guide treatment, which may help reduce discomfort during cancer treatment.
Guangzhou, GuangdongAges 18 years+ - NCT06248944Recruiting
Italian registry for head and neck cancers
This registry collects information from Italian hospitals about people with head and neck cancers. By joining, you help doctors better understand the disease and improve future treatments.
CandioloAges 18 years+ - NCT05708300Recruiting
Testing how mepolizumab works for people with nasal polyps
This study looks at blood and other measures (biomarkers) to understand how well mepolizumab helps people with nasal polyps, with or without asthma. It aims to find response clues that could help personalize treatment in the future.
Thessaloniki, ExochiAges 18 years+ - NCT06219980RecruitingPhase 2
Radiation and immunotherapy before surgery for oral cancer
This trial tests combining radiation therapy with immunotherapy and chemotherapy before surgery for advanced oral or throat cancer. The goal is to see if this approach can shrink the tumor and improve treatment outcomes.
Guangzhou, GuangdongAges 18–70
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.