Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,051 recruiting studies in this area right now.
By phase
- Not applicable2,997
- Phase 21,057
- Phase 1792
- Phase 1/Phase 2437
- Phase 3436
- Phase 4234
- Phase 2/Phase 398
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma327
- Asthma193
- Lymphoma178
- Rheumatoid Arthritis132
- Type 1 Diabetes130
- Atopic Dermatitis125
- Systemic Lupus Erythematosus119
- Acute Lymphoblastic Leukemia118
- HIV Infections106
- Chronic Lymphocytic Leukemia95
- Autoimmune Diseases77
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Diabetes Mellitus, Type 163
- Hodgkin Lymphoma63
- Leukemia63
- Mantle Cell Lymphoma62
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca63
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic49
- City of Hope Medical Center48
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California496
- Maryland200
- Alabama178
- Florida149
- Arizona147
- Massachusetts116
- New York116
- Texas112
- Illinois83
- Colorado82
Recruiting studies6,051 total
- NCT04442412RecruitingPhase 3
Prednisone and vitamin D before chemo for certain lymphomas
This Phase 3 study tests whether a short “pre-treatment” with prednisone, with or without vitamin D, can improve outcomes when followed by standard lymphoma chemo. It aims to see if adding vitamin D early can help older adults tolerate or benefit from treatment for specific lymphoma types.
Brescia, BSAges 65 years+ - NCT05528055RecruitingPhase 1
Safety study of SCR-6920 for advanced cancers
This Phase 1 trial tests whether SCR-6920 capsules are safe and tolerable in people with advanced, treatment-resistant cancers. It may help doctors learn the right way to dose the medicine and check for side effects.
Jinan, ShandongAges 18–75 - NCT03240328RecruitingPhase 1
CAR-T therapy study for rebuilding HIV immune defenses
This early-stage study tests whether CAR-T cells can help rebuild the immune system’s ability to fight HIV. You may be a candidate if your HIV is well controlled on standard treatment and you don’t have certain serious infections or organ problems.
Guangzhou, GuangdongAges 18–60 - NCT04667026Recruiting
Study of people living with HIV on treatment
This is an observational study that follows people with HIV who are taking HIV medicines (antiretroviral therapy). It may help researchers understand how treatment is going and what factors relate to doing well on therapy.
Guangzhou, GuangdongAges 14 years+ - NCT03603977Recruiting
Simplified HIV treatment for people living with HIV
This trial looks at whether a simpler set of HIV medicines works for people with confirmed HIV-1 infection. It may help by making treatment easier to follow, while monitoring health with regular blood tests.
Guangzhou, GuangdongAges 18 years+ - NCT03884673Recruiting
Simpler two-drug HIV treatment with dolutegravir and lamivudine
This trial studies whether taking dolutegravir plus lamivudine (a simpler two-drug regimen) can work as well as a standard three-drug HIV regimen for people who have reasons they can’t stay on the usual medicines. You may be offered free treatment if you meet the safety checks and can attend follow-up visits.
Guangzhou, GuangdongAges 18 years+ - NCT03217396Recruiting
Study blood and MRI markers in people with multiple sclerosis
This study looks for signs of “synapse damage” in multiple sclerosis using blood tests and brain imaging (MRI). The goal is to find biomarkers that may help better understand MS and how it changes over time.
Pozzilli, IserniaAges 18–65 - NCT04855773Recruiting
Mobile text-message support to help people stay on PrEP
This trial tests whether phone-based (iPhone/Android) text-message support can improve how consistently people use PrEP, an HIV prevention medicine. It may help you stay on track with refills and clinic visits, especially if you’re at higher risk of stopping PrEP.
San Francisco, CaliforniaAges 15 years+ - NCT03852407RecruitingPhase 2
Two kinds of conditioning before matched stem cell transplant
This trial compares two reduced-intensity conditioning regimens before you receive stem cells from a donor who matches your HLA type. It aims to find which approach works better and is safer for certain blood cancers.
AntwerpAges 18–75 - NCT05578105Recruiting
Study of autoimmune polyglandular disease genetics in Taiwan
This study looks at how common autoimmune polyglandular syndrome type II is in Taiwan and what genetic differences may be involved. It uses past hospital visit records and focuses on people who had a specific pattern of autoimmune conditions.
TaipeiAges 20 years+ - NCT04645511Recruiting
Balloon treatment for long-term or repeat maxillary sinusitis
This study tests whether balloon sinuplasty works better or more efficiently for people with long-lasting or repeatedly returning inflammation in the maxillary sinuses (side sinuses near your cheeks). It focuses on people who did not improve with the usual nose spray (topical steroid) or who meet specific “recurrent” episode patterns.
TampereAges 18–69 - NCT05593081Recruiting
Study of sudden type 1 diabetes after rapid symptom onset
This trial studies people who develop severe, fast-onset “type 1 diabetes” with body-wide stress (ketosis/ketoacidosis) soon after symptoms start. It aims to better understand this condition and how to care for it early.
Quanzhou, FujianAges Any age - NCT04922567RecruitingPhase 2
Lenalidomide plus CHOP versus CHOP for untreated PTCL
This Phase 2 trial compares two chemotherapy approaches—adding lenalidomide to CHOP versus CHOP alone—for people with untreated peripheral T-cell lymphoma (PTCL). The goal is to see if the added medicine improves response and safety.
Hangzhou, ZhejiangAges 18–75 - NCT03848962Recruiting
Share leftover or collected samples for research
This study helps collect and share human samples (like blood or other specimens) so researchers can do new studies. It’s mainly about providing samples for research use, not testing a treatment on you.
Huntsville, AlabamaAges 1 month–89 years - NCT05626400Recruiting
CAR T for relapsed T-ALL or T-LBL with CD7
This trial tests a type of immune therapy (CAR T cells) called Senl-T7 in people whose T-cell leukemia or lymphoma has come back or did not respond. It aims to target cancer cells that carry a marker called CD7.
Beijingcun, HebeiAges 2–70 - NCT05620680Recruiting
CD7 CAR-T for relapsed or resistant T-cell cancers
This trial studies a type of immune cell therapy (CAR-T) made from your own T-cells, designed to treat T-cell lymphoma or T-cell leukemia that has come back or didn’t respond. It may help by directing your immune system to attack the cancer, and it requires specific eligibility and safety checks.
Shenzhen, GuangdongAges 18–75 - NCT05626348RecruitingPhase 4
Test immune-modulator treatments for rheumatoid arthritis with knee trouble
This Phase 4 trial studies whether immune-modulator medicines improve symptoms and function in people with rheumatoid arthritis who have knee problems. It may also compare responses in osteoarthritis and healthy volunteers, depending on the group you fit.
Jinan, ShandongAges 18–80 - NCT05657847Recruiting
Imaging tests for joint disease in arthritis
This study tests new kinds of imaging (radiology pictures) to help understand arthritis in joints. It may help improve how these arthritis types are identified and followed over time.
BudapestAges 18–100 - NCT05594797RecruitingPhase 2
BCMA CAR-T for multiple myeloma that came back or stopped working
This trial tests a one-time BCMA CAR-T cell treatment for people with multiple myeloma that relapsed or did not respond well to prior treatments. It may help by training your own immune cells to recognize and attack myeloma cells.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05651113Recruiting
Your experience during screening for SCID
This study looks at what it feels like for people to go through screening for SCID (a rare immune condition). It may help improve the screening process and support for patients and families.
LondonAges 18 years+ - NCT02192866Recruiting
Blood samples to study peanut and tree nut allergies
This study collects blood (or uses already-collected blood) to learn why peanut, tree nut, and related food allergies happen and how they behave during challenges. It may help researchers better understand allergies and improve future care.
Denver, ColoradoAges 1–75 - NCT05659628RecruitingPhase 1
CD19 CAR-T plus PD-1 antibody for relapsed lymphoma
This Phase 1 study tests a new type of immune cell therapy (CD19 CAR-T) combined with an anti–PD-1 drug for people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). It aims to improve cancer control when standard treatments have not worked or the cancer has come back.
Hangzhou, ZhejiangAges 18–75 - NCT05674695Recruiting
Registry study for starting or switching atopic eczema medicines
This study follows people with atopic eczema when they start or switch to a specific medicine that affects the immune system. It helps doctors understand how these treatments work in real life, including for skin symptoms and daily quality of life.
Badalona, BarcelonaAges Any age - NCT05682131RecruitingPhase 4
Study for children with certain relapsed leukemia
This trial looks at treatment for children whose leukemia has come back for the first time. It focuses on a specific type of leukemia and risk level to see whether the approach improves outcomes.
Guangzhou, GuangdongAges 1–14
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,051 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,083 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.