Clinical trials
Acute Heart Failure clinical trials
Below are recruiting acute heart failure clinical trials, each written for real people, not researchers. We’re tracking 434 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06128980RecruitingPhase 2/Phase 3
Stopping heart meds after recovery from fast heartbeat damage
This trial tests if patients whose heart function returned to normal after treating a fast heartbeat can safely stop their heart failure medications. It aims to see if treatment can be withdrawn without the heart problems coming back.
CopenhagenAges 18 years+ - NCT06979362RecruitingPhase 2
Study of CDR132L for heart failure with preserved pumping function
This trial tests if CDR132L can improve heart structure and function in people with a type of heart failure where the heart pumps normally but is stiff and thickened. It may help if you have heart failure with preserved ejection fraction and a thickened heart muscle.
Birmingham, AlabamaAges 40–84 - NCT06426173Recruiting
Strength training for people waiting for a heart transplant
This study tests whether resistance training (strength exercises) can help people waiting for a heart transplant. It is for patients who have been on the transplant list for less than a month and are stable enough to exercise safely.
São Paulo, São PauloAges 18–70 - NCT05374291Enrolling by invitationPhase 3
Dapagliflozin trial for kidney and heart outcomes in severe CKD
This study tests whether dapagliflozin can improve kidney and heart-related outcomes in people with severe chronic kidney disease (CKD). You would take the study medicine (or a comparison treatment) and be followed to see how your kidneys and heart do over time.
Canberra, Australian Capital TeritoryAges 18 years+ - NCT06954792Enrolling by invitation
Studying heart changes after tricuspid valve replacement
This study looks at how the heart adjusts after a procedure to replace the tricuspid valve (the valve between the right upper and lower heart chambers). It focuses on patients who need medication to support their blood pressure within 24 hours after the procedure, to better understand and manage this unstable period.
New York, New YorkAges 18 years+ - NCT06979375RecruitingPhase 2
Study of CDR132L for heart failure with reduced pumping ability and thickened heart muscle
This trial tests a new medicine called CDR132L to see if it improves heart structure and function in people with heart failure who have a thickened heart muscle and reduced pumping ability. Participants will be randomly assigned to receive either the study drug or a placebo.
Concord, New South WalesAges 40–84 - NCT07076615RecruitingPhase 4
Dapagliflozin for acute heart failure
This trial tests if a medicine called dapagliflozin (Farxiga) helps people with acute heart failure. You may qualify if you are in the hospital or ER for heart failure and need IV water pills.
CairoAges 18 years+ - NCT06161987Recruiting
Early rehab for acute heart failure
This study tests whether starting a tailored exercise and education program early in the hospital can help people with acute heart failure recover faster and feel better. It includes walking, breathing exercises, and support to get you back to daily activities.
Guangzhou, GuangdongAges 18–80 - NCT06272734Recruiting
Reprieve system study for hospitalized heart failure
This study tests a device (Reprieve System) to remove extra fluid more safely in heart failure patients while they are hospitalized. It may be a good option if you have fluid buildup and are not too sick from other conditions.
TbilisiAges 18 years+ - NCT05759806Recruiting
Testing a device to treat fluid overload in heart failure
This trial studies a device (the Nephronyx System) used in the hospital to treat worsening heart failure with fluid buildup, especially when diuretics (water pills) aren’t working well. It aims to check the device’s safety and whether it performs as expected to help patients get better.
HaifaAges 18 years+ - NCT04905160Recruiting
Care planning after hospital stays to reduce readmissions
This study tests a care-coordination plan to see if it helps people leave the hospital and prevents them from needing to come back soon. It focuses on certain heart-related hospital diagnoses and, for some parts, also includes people with recent COVID-19.
Phoenix, ArizonaAges 18 years+ - NCT07403669Recruiting
Heart, kidney, and metabolic health assessment study
This trial offers a health assessment and empowerment program for adults who have heart, kidney, or metabolic conditions like diabetes or heart disease. It aims to help you better manage your health.
Chandler, ArizonaAges 18 years+ - NCT07643610Recruiting
Heart Failure Crisis Registry Study
This registry collects information from patients admitted to the hospital with cardiogenic shock—a serious condition where the heart cannot pump enough blood to the body. Doctors will gather data to better understand what happens to these patients and how to improve their care.
Basel, Canton of Basel-CityAges 18 years+ - NCT05689645RecruitingPhase 2
Drug trial for liver injury or liver failure
This Phase 2 trial tests an injection medicine (F573) to see if it can improve people with liver injury, drug-related liver damage, or liver failure. You may be screened with blood tests, liver stiffness measurements, and possibly symptom checks.
Beijing, Beijing MunicipalityAges 18–60 - NCT07365501Enrolling by invitation
Blood pressure cuff therapy for heart failure patients
This trial tests if a simple, non-invasive blood pressure cuff procedure can improve blood vessel health in people with possible heart failure. It is an early, single-session study to see how the body responds.
Cuenca, CuencaAges 18 years+ - NCT05553886RecruitingPhase 3
Tablets for chronic heart failure with low pumping strength
This Phase 3 study tests whether S086 tablets can improve treatment for people with chronic heart failure where the heart pumps weakly. You may be eligible if your heart failure symptoms are moderate to severe and your condition is stable on current medicines, but not if you’ve recently had certain heart events or can’t take related blood-pressure/heart drugs.
Shenzhen, GuangdongAges 18 years+ - NCT07202000RecruitingPhase 2
Exercise and a drug to reduce inflammation for heart failure with preserved ejection fraction
This trial tests whether combining exercise with a medication that blocks a protein called activin can reduce inflammation, improve heart function, and help with thinking in people with heart failure with preserved ejection fraction (HFpEF).
Boston, MassachusettsAges 40 years+ - NCT07592494Recruiting
Arm Exercise Training for Heart Failure With Device
This study compares different types of arm exercises for people with heart failure who have a pacemaker or defibrillator implanted. The goal is to see which exercise approach best improves how well your arms function and help you stay active.
ÇorumAges 18 years+ - NCT06055452RecruitingPhase 4
SGLT2 Inhibitors for Pre-Heart Failure with Hypertension
This trial tests if a medicine (SGLT2 inhibitor) given to people with high blood pressure and early signs of heart stress can help prevent heart failure. You may join if your blood pressure is controlled but tests show your heart is beginning to struggle.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06081049RecruitingPhase 2
Colchicine for heart failure with preserved pumping function
This trial is testing whether colchicine, a medication used for gout, can help people with a specific type of heart failure where the heart pumps normally but is stiff. If you have heart failure with preserved pumping and certain signs of inflammation, this study might be a good fit.
HellerupAges 40 years+ - NCT07465653RecruitingPhase 1
Study of HJB647 for heart failure with reduced pumping ability
This trial tests a new medicine, HJB647, in people with heart failure who have a weak heart pump. It aims to see if the drug is safe and well-tolerated. You may qualify if your heart's pumping ability is reduced and you are on a specific standard therapy.
Bradenton, FloridaAges 18–100 - NCT06862908RecruitingPhase 2
Study of IBI362 for heart failure with obesity
This study tests a new medicine called IBI362 for people with heart failure and obesity. The medicine may help improve symptoms and quality of life. You must have a specific type of heart failure (HFpEF or HFmrEF) and a BMI of 28 or higher.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07265349RecruitingPhase 1/Phase 2
Stem cells plus bypass surgery for chronic heart failure
This trial tests whether injecting stem cells from umbilical cord tissue into the heart muscle during bypass surgery can improve heart function in people with chronic heart failure. It is for patients who are already scheduled for bypass surgery and have a weakened heart pump (LVEF between 21% and 40%).
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05508035RecruitingPhase 3
Testing sacubitril/valsartan vs ramipril for heart failure
This trial compares two blood-pressure and heart-failure medicines: sacubitril/valsartan versus ramipril, to see which improves heart pumping and heart structure over time. It’s aimed at people with ischemic (blocked-artery) heart failure with mid-range ejection fraction and ongoing symptoms.
Krakow, Lesser Poland VoivodeshipAges 18 years+
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Common questions
- Are there clinical trials for acute heart failure?
- Yes. Clin2 currently lists 434 recruiting acute heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.