Clinical trials
Advanced clinical trials
Below are recruiting advanced clinical trials, each written for real people, not researchers. We’re tracking 3,988 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06427954Recruiting
Mobile app study for people with advanced lung cancer
This study tests a mobile app (called THRIVE) to help people with advanced lung cancer manage their health and well-being. You'll use the app on your phone to track symptoms and get support, which may help you feel better and stay more in control.
Los Angeles, CaliforniaAges 18 years+ - NCT06430502Recruiting
Cancer vaccine plus immunotherapy for advanced solid tumors
This trial tests a cancer vaccine (called TTV) combined with a PD-1 inhibitor (a type of immunotherapy) for people with advanced solid tumors that have not responded to standard treatments. The goal is to see if this new combination helps shrink tumors or slow cancer growth.
Wuxi, JiangsuAges 18–85 - NCT06430515Recruiting
Injecting chemo into tumors for advanced solid cancers
This trial tests if injecting chemotherapy directly into tumors can help people with advanced solid cancers that have stopped responding to standard treatments. It aims to see how safe and effective this approach is.
Wuxi, JiangsuAges 18–85 - NCT06431594RecruitingPhase 1
Study of a new drug for advanced solid tumors
This trial tests a new drug called Mocertatug Rezetecan for people with advanced solid tumors that have stopped responding to standard treatments. It targets a protein called B7-H4 on cancer cells to try to slow or shrink the tumor.
Birmingham, AlabamaAges 18 years+ - NCT06432491Recruiting
Core Temperature and Health in Healthy Adults 50–65
This study will look at how core body temperature relates to your overall health, by monitoring temperature patterns in healthy adults aged 50–65 who live in Shenzhen. It aims to find connections that could help predict or prevent health issues.
Shenzhen, GuangdongAges 50–65 - NCT06432504Recruiting
How coffee affects your energy use
This study looks at how coffee affects your body's energy use (metabolic rate). It may help researchers understand the effects of coffee on healthy adults.
Shenzhen, GuangdongAges 18–40 - NCT06432517Recruiting
Studying energy use in healthy men
This trial is looking at how healthy men's bodies use energy. It may help us understand weight and metabolism better.
Shenzhen, GuangdongAges 18–40 - NCT06438822RecruitingPhase 2
Immunotherapy plus chemo for advanced bile duct cancer
This trial tests a combination of a new immunotherapy drug (cadonilimab) with three chemotherapy drugs for advanced bile duct or gallbladder cancer that has already been treated with gemcitabine. The goal is to see if adding immunotherapy helps control the cancer better.
Chengdu, SichuanAges 18–75 - NCT06438900Recruiting
Studying AGEs and muscle loss in obesity and diabetes
This study is looking at how certain sugar-related proteins (called AGEs) might be linked to muscle loss in people with obesity and type 2 diabetes. It aims to understand why muscle wasting happens in this condition.
NovaraAges 18 years+ - NCT06439771RecruitingPhase 2
Testing YL202 for advanced breast cancer
This trial tests a new drug called YL202 for people with advanced breast cancer. It is for those who have already tried certain targeted treatments (HER2 or TROP2 antibody-drug conjugates) and they stopped working. The goal is to see if YL202 can help shrink tumors or slow cancer growth.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06440057RecruitingPhase 1/Phase 2
Study of ZG006 for advanced lung and neuroendocrine cancers
This trial is testing a new drug called ZG006 for people with advanced small cell lung cancer or neuroendocrine carcinoma. The study has two parts: first finding the right dose, then testing it in more people with neuroendocrine carcinoma.
Beijing, Beijing MunicipalityAges 18–75 - NCT06441747RecruitingPhase 2
Durvalumab and olaparib for advanced bile duct cancer
This trial tests a combination of two drugs—durvalumab (an immunotherapy) and olaparib (a targeted therapy)—for people with advanced bile duct cancer that did not grow after initial treatment with chemotherapy and durvalumab. The goal is to see if this combination can help control the cancer further.
Camperdown, New South WalesAges 18 years+ - NCT06444009RecruitingPhase 2
Immunotherapy and chemo before surgery for head and neck cancer
This trial tests whether giving immunotherapy along with chemotherapy before surgery can help treat locally advanced head and neck cancer that can be removed. The goal is to see if this combination shrinks tumors and improves outcomes.
Chengdu, SichuanAges 18–75 - NCT06448572RecruitingPhase 1/Phase 2
EXL01 and nivolumab for immunotherapy-resistant lung cancer
This trial tests an investigational microbiome therapy (EXL01) combined with nivolumab (an immunotherapy) for people with advanced non-small cell lung cancer whose cancer continued to grow after standard immunotherapy and chemotherapy. The goal is to see if adding EXL01 can help the immune system fight the cancer again.
LilleAges 18 years+ - NCT06451497RecruitingPhase 1
Testing ZM008 alone and with toripalimab for advanced cancers
This trial tests a new drug called ZM008, which targets a protein on some cancer cells, first alone and then combined with another drug, toripalimab, for people with advanced solid tumors that have stopped responding to standard treatments.
Boston, MassachusettsAges 18 years+ - NCT06452160RecruitingPhase 1
Study of BGC515 for advanced solid tumors
This trial tests an experimental drug called BGC515 for people with advanced solid tumors, including mesothelioma and EHE, that have not responded to standard treatments. The drug works by targeting a specific cell signaling pathway (Hippo) that may be involved in cancer growth.
Houston, TexasAges 18 years+ - NCT06458088Recruiting
Sugar-related substances and blood vessel problems in type 1 diabetes
This study looks at how certain sugar-related substances in the blood (called advanced glycation products) are linked to blood vessel problems in people with type 1 diabetes. It follows up with participants from an earlier study at Reims Hospital.
ReimsAges 18 years+ - NCT06460012Recruiting
Phone support for dementia caregivers (living & learning)
This study tests a support program delivered by phone to help caregivers of people with Alzheimer's or dementia manage challenging behaviors and reduce their own stress. You'll receive coaching and resources, answer surveys, and learn practical strategies.
Portland, OregonAges 18 years+ - NCT06461780Recruiting
Needs and Quality of Life in Advanced Cancer on Immunotherapy
This study looks at the physical and emotional needs of people with advanced cancer who are receiving immunotherapy. It aims to understand how these needs affect quality of life.
TaipeiAges 18 years+ - NCT06462378RecruitingPhase 2
Proton therapy for advanced cervical cancer
This trial tests whether a precise type of radiation called proton therapy can work well for cervical cancer that has spread to lymph nodes. It aims to see if this treatment can shrink tumors with fewer side effects.
CopenhagenAges 18–99 - NCT06463483Recruiting
Automated Insulin Delivery for People with Advanced Kidney Disease
This trial tests an automated insulin pump system for people with diabetes who also have advanced kidney disease. It may help manage blood sugar more easily.
LondonAges 18–70 - NCT06467383Recruiting
Study of lung cancer care after surgery or radiation
This study is looking back at the medical records of people with early-stage non-small cell lung cancer who had surgery or radiation therapy between 2018 and 2019. The goal is to understand how patients were diagnosed and treated, which may help improve care for others in the future.
San Giovanni Rotondo, FGAges 18 years+ - NCT06467500RecruitingPhase 2
Cadonilimab plus chemo for lung cancer after immunotherapy
This trial tests a new drug called cadonilimab combined with chemotherapy for people with advanced lung cancer who have already tried and failed immunotherapy. It aims to see if this combination can help when standard immunotherapy no longer works.
YichangAges 18–75 - NCT06472063Recruiting
Surgery first vs chemo then surgery for advanced stomach cancer
This trial compares two approaches for stomach cancer that has spread a bit but can still be removed with surgery. One group has surgery first, the other gets chemotherapy before surgery. The goal is to see which sequence leads to better long-term outcomes.
Orbassano, PiedmontAges 18 years+
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Common questions
- Are there clinical trials for advanced?
- Yes. Clin2 currently lists 3,988 recruiting advanced studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.