Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06581861Recruiting
Family study to prevent ALS and FTD
This study is for adults who have a strong family history of ALS or FTD (like a parent or sibling with the disease) to help researchers understand how to prevent these conditions. It involves following you for about a year to track your health.
Birmingham, AlabamaAges 18 years+ - NCT06578195Recruiting
Assess all ALS study
This study follows people with ALS and healthy volunteers over time to understand the disease better. You can join from home using a smartphone or computer.
Birmingham, AlabamaAges 18 years+ - NCT06528964Recruiting
Skin protein study for Alzheimer's, Parkinson's, and related disorders
This study looks at the skin of people with memory or movement disorders (like Alzheimer's, Parkinson's, ALS) to find proteins that may help diagnose these conditions. If you have one of these diseases or are a healthy older adult, you may be able to join by giving a small skin sample.
San Luis Potosí CityAges 45 years+ - NCT06527222RecruitingPhase 2
Ranolazine for muscle cramps in ALS
This trial tests if a heart medication called ranolazine can reduce painful muscle cramps in people with ALS. If you experience frequent cramps and meet the other criteria, this study may be an option for you.
San Francisco, CaliforniaAges 18 years+ - NCT06491732Recruiting
Muscle Scan as an ALS Biomarker
This study tests a device called Myolex mScan that measures muscle health non-invasively in people with ALS. It aims to see if this can be a useful biomarker to track the disease progression.
Phoenix, ArizonaAges 18 years+ - NCT06429735Recruiting
Robot-implanted brain-computer interface for severe paralysis
This trial tests a brain-computer interface (a device that lets you control a computer with your thoughts) that is implanted by a robot. It is for people with severe paralysis who may benefit from a new way to communicate or control devices.
Phoenix, ArizonaAges 22–75 - NCT06396260Recruiting
Brain network study in ALS with emotional outbursts
This study looks at how ALS affects the brain's structure and networks, especially in people who have sudden emotional outbursts (pseudobulbar affect). You will have brain scans (MRI and MEG) and answer questions to help researchers understand these changes.
Aalborg, Northern JutlandAges 18–90 - NCT06337578Recruiting
Telephone-based cognitive screening study
This study tests if a phone-based cognitive screening can effectively assess thinking and memory. It may help people who can't easily visit a clinic.
MilanAges 18–100 - NCT06318585Recruiting
Building a database for motor neuron disease research
This study collects information from people with ALS or other motor neuron diseases to better understand how these conditions vary. By joining a database, you help researchers find patterns that could improve care.
Milan, MIAges 18 years+ - NCT06284161Recruiting
QCT scan for ALS diagnosis and monitoring
This study uses quantitative computed tomography (QCT), a special type of CT scan, to help diagnose ALS, understand how it affects the body, and track its progression over time. It is for people who may have ALS and meet specific diagnostic criteria.
Clermont-FerrandAges 18 years+ - NCT06280079Recruiting
High-calorie fatty diet for ALS patients
This trial tests a very high-calorie, fatty diet to see if it helps people with ALS. If you have been diagnosed recently and are not too advanced in the disease, this special diet may give your body extra energy to slow progression.
AachenAges 18 years+ - NCT06266403Recruiting
Studying how people with ALS communicate in conversations
This study looks at how people with ALS and their conversation partners talk with each other. It aims to understand changes in speech and find better ways to support communication.
University Park, PennsylvaniaAges 18–90 - NCT06249867RecruitingPhase 2
Darifenacin for ALS: safety and effect
This trial tests whether darifenacin, a drug currently used for bladder control, can safely help people with ALS. It aims to understand how the drug works in the body and if it can slow the disease or relieve symptoms.
Ottawa, OntarioAges 18–85 - NCT06249412Recruiting
Positive pressure breathing device for ALS patients
This trial tests whether a mask that helps you breathe out (positive expiratory pressure) combined with a cough-assist machine (in-exsufflator) improves breathing and coughing in people with ALS who have bulbar symptoms like trouble speaking, swallowing, or drooling.
Le Havre, NormandyAges 18–100 - NCT06219759Recruiting
Nerve Reconnection and Signals in ALS
This study looks at how nerves reconnect and send signals to muscles in people with ALS. It may help doctors understand the disease better and find new ways to treat it.
Aarhus, Central JutlandAges 18 years+ - NCT06203106Recruiting
NYSCF Scientific Discovery Biobank
This study collects blood, saliva, or skin samples from people with certain neurological conditions and from healthy volunteers to help researchers better understand and find treatments for these diseases.
New York, New YorkAges 4 weeks+ - NCT06172621Recruiting
Spinal cord stimulation study for ALS hand weakness
This study tests whether combining brain and spinal cord stimulation can improve hand function in people with ALS who have partial weakness but still some movement in their fingers. The goal is to see if this non-invasive approach can strengthen nerve connections.
The Bronx, New YorkAges 18–80 - NCT06126315RecruitingPhase 2/Phase 3
Testing acetyl-L-carnitine in early ALS
This study tests a supplement called acetyl-L-carnitine (ALCAR) to see if it can slow the progression of ALS. It is for people in the early stages of the disease who are already taking riluzole and have good lung and muscle function.
SydneyAges 18 years+ - NCT06094205Recruiting
BrainGate2 speech study for people with tetraplegia
This study tests a brain-computer interface to help people with severe paralysis communicate by decoding attempted speech or movements. It may offer a new way to interact with devices using only brain signals.
Sacramento, CaliforniaAges 18–80 - NCT05995782RecruitingPhase 1
Testing safety of FB418 in healthy people
This trial studies a new drug called FB418 to see if it's safe and how the body handles it. It first tests single doses in younger healthy men, then multiple doses, and also includes an optional group for healthy older adults.
SeoulAges 19 years+ - NCT05983211Recruiting
TMS therapy study for ALS patients
This trial tests whether repetitive TMS (transcranial magnetic stimulation) can help people with ALS. It uses a special type of TMS that is repeated and measured. You would lie comfortably for about an hour while receiving the treatment.
Toronto, OntarioAges 18 years+ - NCT05923905RecruitingPhase 4
Study of FB1006 for people with early ALS
This trial tests whether FB1006 is safe and works better than usual care for treating amyotrophic lateral sclerosis (ALS). It focuses on people with relatively early ALS and good breathing function.
Beijing, Beijing MunicipalityAges 18–80 - NCT05852418Recruiting
Registry study of devices, medicines, and care in ALS and SMA
This study collects information in a registry about assistive devices, medicines, and healthcare support for people with long-term neurological conditions like ALS and SMA. It may help researchers understand what treatments and supports are used and how they relate to patients’ needs over time.
BerlinAges 18 years+
Hear when a new Amyotrophic Lateral Sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 186 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.