Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 188 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06819124Recruiting
Study on interactions between people with ALS and their caregivers
This study looks at how people with ALS and their caregivers talk and interact with each other. It may help researchers understand communication challenges and improve support for both.
University Park, PennsylvaniaAges 18–90 - NCT06828523Recruiting
Interactive tasks and how we hear them
This study tests how listening to speech during interactive tasks affects what you hear. It may help us understand how people communicate in everyday situations.
University Park, PennsylvaniaAges 18–65 - NCT06829212Recruiting
Wireless brain implant for device control
This trial tests a wireless brain implant that lets you control external devices like a computer or wheelchair just by thinking. It's designed for people with paralysis or double arm amputations who want to regain some independence.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06849609RecruitingEarly Phase 1
Gene therapy VGN-R13 for ALS safety and tolerability
This study tests a new gene therapy called VGN-R13 for people with ALS. It aims to see if the treatment is safe and tolerable, and if it can slow down the disease. You may be able to join if your ALS symptoms started recently and your lung function is still fairly good.
Wuhan, HubeiAges 18 years+ - NCT06856850Recruiting
Biosignatures in ALS and FTD
This trial collects biological samples from people with ALS or frontotemporal dementia (FTD) to find new markers that could lead to better understanding and treatment. You may be able to participate if you have been diagnosed with either condition.
MilanAges 18 years+ - NCT06877143Recruiting
High-calorie PEG nutrition for ALS energy needs
This trial tests whether a special high-calorie formula given through a PEG tube can help people with ALS maintain energy balance and potentially slow disease progression. It is for adults with ALS who are already using a PEG tube for nutrition.
Ulm, Baden-WurttembergAges 18 years+ - NCT06881979Recruiting
High-tech rehab for chronic neuromuscular diseases
This study tests a high-tech rehabilitation program for people with long-term nerve and muscle conditions. It aims to help you improve your walking and daily function using advanced technology.
GenovaAges 18–80 - NCT06891716RecruitingEarly Phase 1
PET imaging study for TDP-43 protein disorders
This study uses a special PET scan to detect TDP-43 protein buildup in the brain, which is linked to conditions like frontotemporal dementia and ALS. Healthy volunteers and people with TDP-43 disorders are invited to take part.
AmsterdamAges 40–70 - NCT06917924Recruiting
Tailored ALS trial using genetics and stem cells
This study aims to better understand ALS by looking at your genes, biomarkers, and stem cells. It may help develop treatments that are personalized to you.
MilanAges 18 years+ - NCT06992596Recruiting
Brain implant study for controlling devices with thoughts
This trial tests a brain implant that lets you control external devices using your thoughts. It's for people with limited arm function due to spinal cord injury, stroke, ALS, or similar conditions.
Abu DhabiAges 18 years+ - NCT07017946RecruitingPhase 1/Phase 2
Gut bacteria transplant for fast-progressing ALS
This trial tests whether a transplant of healthy gut bacteria (called a microbiome transplant) can slow down ALS in people whose disease is progressing rapidly. It aims to see if changing the gut environment can help with symptoms and quality of life.
Durham, North CarolinaAges 18 years+ - NCT07067229Recruiting
Brain stimulation and exercise for motor neuron disease
This study tests whether combining non-invasive brain stimulation (a gentle, non-surgical treatment) with exercise can help people with motor neuron disease (MND). It may improve movement and quality of life for those with mild to moderate symptoms.
Bangkok, PathumwanAges 18–80 - NCT07127172Recruiting
Brain implant study for controlling devices with your mind
This study tests a brain implant that lets you control external devices like a computer or tablet just by thinking. It is for people with paralysis or severe weakness in both arms due to conditions like spinal cord injury, ALS, or stroke.
London, Greater LondonAges 18 years+ - NCT07161999RecruitingPhase 2
Study of COYA 302 for treating ALS
This trial tests a new drug called COYA 302 to see if it can slow down ALS. People in the study must have a recent diagnosis, a certain level of physical function, and be between 18 and 80 years old.
Phoenix, ArizonaAges 18–80 - NCT07224256Recruiting
Brain implant trial to help with communication after injury or disease
This trial tests a brain-computer interface (BCI) that is implanted by a robot. It is designed to help people who have lost the ability to speak clearly or use their hands well, due to conditions like ALS, stroke, or spinal cord injury.
Dallas, TexasAges 22–75 - NCT07235111Recruiting
Studying biomarkers for neurodegenerative diseases
This study is looking for people with neurodegenerative diseases (like Alzheimer's, Parkinson's, ALS) to help researchers find new markers in the body that could help understand these conditions better and possibly lead to better treatments.
Genoa, GenoaAges 18 years+ - NCT07268833Recruiting
Finding new ALS biomarkers from nerve cells and blood
This study looks for new ways to detect and understand ALS by analyzing tiny nerve and blood markers. It may help find better treatments for ALS and related nerve diseases.
Monserrato, CaliforniaAges 18 years+ - NCT07287397RecruitingPhase 1/Phase 2
Testing VTx-002 for safety in ALS patients
This trial tests a new drug called VTx-002 to see if it is safe and tolerable for people with ALS. You may be able to join if you have had symptoms for less than 18 months and have a caregiver who can help.
Phoenix, ArizonaAges 18 years+ - NCT07292545Recruiting
Video exercise program for balance and coordination in ALS
This study tests whether a video-guided exercise program for body awareness and movement control can help people with ALS improve their balance and daily function. It may be an option if you can sit up on your own and don't have other nerve or muscle problems.
Mersin, TARSUSAges 18–70 - NCT07294144RecruitingPhase 2
Tofersen for ALS without SOD1 or FUS mutations
This trial tests if tofersen, a drug that targets a protein linked to ALS, can help people who have ALS but do not have mutations in the SOD1 or FUS genes. It aims to slow disease progression in those diagnosed within the last 2 years.
Atlanta, GeorgiaAges 18 years+ - NCT07302321Recruiting
Needs of ALS patients with C9orf72 mutation and their caregivers
This study asks people with ALS who have a specific genetic change (C9orf72) and their caregivers to fill out an online survey. It aims to better understand their needs so that support can be improved.
Milan, LombardyAges 18 years+ - NCT07312240Recruiting
Biomarkers in ALS: A long-term study
This study is looking for people with ALS to help doctors understand how certain biological markers (biomarkers) change over time. It involves a lumbar puncture (spinal tap) to collect fluid from your spine and regular check-ups.
Milan, LombardyAges 18 years+ - NCT07334743Recruiting
A study to find biomarkers in ALS using tiny brain particles
This trial collects blood and spinal fluid samples from people being checked for ALS. The goal is to find clues (biomarkers) in tiny particles from nerve cells that could help doctors better understand and diagnose ALS.
ParisAges 18 years+ - NCT07357428Recruiting
Brain-computer implant study for severe paralysis or speech loss
This study tests a brain-computer implant that might help people with severe paralysis or speech loss control a computer with their thoughts. It is for people who have trouble moving and speaking due to a progressive disease or injury.
Sacramento, CaliforniaAges 22–75
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 188 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.